基于基底外侧杏仁核-屏状核神经环路的社交障碍动物模型构建方法及其应用
By injecting viral vectors containing photosensitive protein or photoinhibitory protein genes into the basolateral amygdala-claustrum neural circuit and applying light stimulation using optical fibers, an animal model of social disorder was constructed. This solved the problem of insufficient mechanism specificity in existing models and enabled precise regulation of social behavior and drug screening.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHANDONG FIRST MEDICAL UNIV & SHANDONG ACADEMY OF MEDICAL SCI
- Filing Date
- 2026-04-17
- Publication Date
- 2026-07-17
AI Technical Summary
Existing animal models of social disorders suffer from insufficient mechanism specificity, developmental stage dependence, and poor reproducibility, making it difficult to clarify the direct neural basis of social deficits.
By injecting viral vectors containing photosensitive protein or photoinhibitory protein genes into the amygdala-claustrum neural circuit on the basolateral side of an animal, and applying light stimulation of specific wavelengths and frequencies using optical fibers, neural projections can be activated or inhibited, thus constructing or alleviating models of social impairment.
It achieves precise regulation of social behavior, constructs an animal model with a clear mechanism and verifiable causality, and is used for mechanism research and drug screening of social disorders, without being accompanied by anxiety or changes in motor ability.
Smart Images
Figure CN122030335B_ABST