基于拉曼光谱的胸部肿瘤外泌体检测方法
By utilizing adaptive filtering and gain processing techniques in the detection of thoracic tumor exosomes, the problem of high false positive rate in existing technologies has been solved, and more accurate detection of tumor exosome biomarkers has been achieved.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHANXI CANCER HOSPITAL
- Filing Date
- 2026-04-15
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies have a high misclassification rate in the detection of exosomes in thoracic tumors, especially when the effective signal is difficult to separate from background interference at extremely low exosome concentrations. Surface-enhanced Raman scattering technology introduces false positive peaks, resulting in a high misclassification rate of tumor exosome markers.
By analyzing multiple pre-acquired noise Raman spectra, the noise Raman spectrum with the smallest difference is determined as the reference Raman spectrum. Adaptive filtering is then performed, and gain processing is applied based on the energy distribution to eliminate false positive peaks and improve detection accuracy.
It effectively reduced the misjudgment rate of tumor exosome markers and improved the accuracy and reliability of detection information.
Smart Images
Figure CN122030895B_ABST