A trehalose dressing lyophilizer and method
By combining the flipping operation with the planetary gear set, the problem of uneven drying in the trehalose dressing freeze-drying equipment was solved, achieving efficient multi-directional moisture discharge and uniform drying, and reducing energy consumption.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- TAIZHOU RENKANG BIOTECH
- Filing Date
- 2026-04-14
- Publication Date
- 2026-07-21
AI Technical Summary
Existing rotary freeze-drying equipment suffers from uneven drying and long drying times when processing trehalose dressings due to tray obstruction and impeded water vapor escape.
The flipping operation transforms the trehalose dressing precursor from single-sided processing to five-sided simultaneous processing. The cooperation between the extrusion plate and the material container ensures stability and uniform drying during the flipping process. The planetary gear set maintains the stability of the equipment and enables multi-directional moisture discharge.
It shortens freeze-drying time, reduces energy consumption, and achieves uniform drying without changing the size of the equipment, thereby improving heat and mass transfer efficiency.
Smart Images
Figure CN122041518B_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of trehalose dressing freeze-drying technology, and more particularly to a trehalose dressing freeze-drying machine and method. Background Technology
[0002] In recent years, the chronicity of wounds and the inactivation of bioactive ingredients have become the core contradictions faced by modern dressings. Although traditional hydrogel or foam dressings have moisturizing and physical barrier functions, they cannot stably load and sustain the release of heat-sensitive therapeutic factors, resulting in limited clinical efficacy. Trehalose, as a natural sugar, can form a stable "glass"-like structure in a dry state, acting as a "molecular scaffold" to encapsulate and protect easily inactivated active ingredients such as growth factors and exosomes, allowing them to maintain their efficacy for a long time at room temperature. Therefore, it is widely used to prepare novel active dressings (especially suitable for refractory wounds such as diabetic foot ulcers).
[0003] Currently, these dressings are generally made using freeze-drying (lyophilization) technology, which mainly relies on two key functions: (1) by rapidly freezing and then vacuum drying at low temperature, trehalose is kept in an amorphous state, thereby playing its "molecular-level protection" function and preventing the active ingredients from being heated or dehydrated; (2) during the freeze-drying process, water exists in the form of ice crystals, which then sublimate and escape, leaving a large number of interconnected micropores to form a loose and porous three-dimensional skeleton. This allows wound exudate to be absorbed quickly, drugs to be released slowly, and to fit closely to irregular wound surfaces.
[0004] However, existing rotary freeze-drying equipment and processes have revealed systemic technical defects when applied to such trehalose dressings: when traditional rotary freeze dryers process freeze-drying, the escaping of water vapor on the side in contact with the tray is hindered due to the obstruction of the tray and the influence of water vapor formed by the sublimation of water on the upper part of the trehalose dressing precursor, resulting in delayed drying, uneven drying, and consequently, a long drying time. Summary of the Invention
[0005] To address the problems mentioned in the background section, this invention provides a trehalose dressing freeze dryer and method.
[0006] The technical solution of the present invention is as follows: a trehalose dressing freeze dryer includes a housing, a support frame is provided inside the housing, a support shaft is fixedly connected to the support frame, two rotating frames are rotatably connected to the support shaft, a drive module for driving the rotating frames to rotate is provided on the support shaft, a bearing frame distributed in a ring array is rotatably connected between the two rotating frames, a material holding component is detachably connected to the bearing frame, a plurality of telescopic sleeves are provided inside the material holding component, and an extrusion plate is provided on the bearing frame for supporting the material inside the material holding component.
[0007] Preferably, an electric push rod is provided on the side of the bearing frame away from the material container, and a U-shaped frame that is slidably connected to the telescopic end of the electric push rod is fixedly connected to the bearing frame. A plurality of first elastic telescopic rods are fixedly connected on the side of the U-shaped frame away from the electric push rod, and the telescopic ends of the plurality of first elastic telescopic rods are all fixedly connected to the extrusion plate.
[0008] Preferably, an arc-shaped plate is fixed to the outer edge of the extrusion plate.
[0009] Preferably, fixed gears are rotatably connected to both sides of the support shaft, and a circular array of transmission gears is rotatably connected to the rotating frame. The circular array of transmission gears meshes with the adjacent fixed gears. Each transmission gear corresponds to a bearing frame. A driven gear is rotatably connected to the bearing frame, and the driven gear meshes with the corresponding transmission gear.
[0010] Preferably, the telescopic sleeve is composed of a hollow connecting plate, a hinge plate, and a tension spring. The hollow connecting plate and the hinge plate, and the tension spring are fixedly connected between the hollow connecting plate and the hinge plate. The hinge plate in one side of the telescopic sleeve within the same material holding component is hinged to the material holding component, and the hollow connecting plate in the other side of the telescopic sleeve within the same material holding component is hinged to the material holding component. The hollow connecting plates and the hinge plates on two adjacent telescopic sleeves are hinged to each other.
[0011] Preferably, the hinge plate is provided with a rectangular groove for providing a channel for gas discharge.
[0012] Preferably, a fixing frame is fixedly connected to the side of the bearing frame away from the electric push rod, and a second spring telescopic rod is fixedly connected to the fixing frame. A pressing seat is fixedly connected to the telescopic end of the second spring telescopic rod, and the pressing seat is used to press the adjacent hollow connecting plate.
[0013] Preferably, the fixed frame is hinged with two rocker arms, the extrusion seat is provided with two pairs of sliding grooves, and the side of the rocker arm near the extrusion seat is slidably connected to one of the pairs of sliding grooves. The U-shaped frame is used to extrude the two rocker arms.
[0014] Preferably, the support shaft is equipped with a drive motor, the drive motor is fixedly connected to a transmission shaft, and the transmission shaft is connected to the fixed gear in a transmission connection.
[0015] A method for using a trehalose dressing freeze dryer, based on a trehalose dressing freeze dryer, the specific structure of which is as follows: Step 1: Material preparation: Remove the material container from the carrier frame, lay the trehalose dressing precursor flat on the inside of the material container, and then reassemble the material container onto the carrier frame; Step 2: Low-temperature drying start-up and rotation: After all the material-holding parts are assembled, the equipment shell is closed, the equipment shell is evacuated and cooled to form a freeze-drying environment, the drive module is started and drives the rotating frame to rotate, all the rotating frames drive all the bearing frames to rotate synchronously, and through the planetary gear set composed of fixed gears, transmission gears and driven gears, each bearing frame and auxiliary parts are kept in a horizontal state during the revolution. Step 3: Triggering flipping after initial freezing: After the upper side of the trehalose dressing precursor is initially frozen, the electric push rod extension extends, causing the U-shaped frame to move downward along the support frame. The U-shaped frame drives the extrusion plate downward through the first elastic telescopic rod, inserts into the adjacent material container and fits with it. The U-shaped frame continues to move downward and contacts the outside of the rocker arm, causing the rocker arm to swing around the fixed frame, raising the extrusion seat to extrude the adjacent hollow connecting plates. This forces all the hollow connecting plates and hinge plates in the same material container to undergo elastic deformation from the middle, forming an arc shape as a whole, with the tension spring stretching synchronously. Step 4: 180° flipping action: When all the hollow connecting plates and hinge plates in the same holding part undergo elastic deformation from the middle until the rectangular groove of the hinge plate is exposed, the electric push rod telescopic part stops extending, the drive motor starts, and drives the fixed gear to rotate via the transmission shaft. The fixed gear drives the corresponding holding part to rotate relative to the horizontal plane through the transmission gear and the driven gear. After the holding part completes 180° rotation, the drive motor stops. At this time, the original lower side of the precursor body turns to the upper side and is in a frozen and shaped state. Then the electric push rod continues to extend, increasing the squeezing force on the rocker arm, causing the squeezing seat to rise further and intensifying the deformation of the hollow connecting plate and hinge plate. Step 5: Flipping and detachment: The intensified arc deformation causes the trehalose dressing to detach from the hollow connecting plate and the hinge plate and fall onto the extrusion plate. Then the electric push rod telescopic part retracts, the U-shaped frame moves upward to reset, and the hollow connecting plate and the hinge plate gradually return to straight under the action of the tension spring. The extrusion plate resets and moves to the initial position. Step 6: Reset and Start Heating and Drying: After the low-temperature drying process is completed, the electric push rod extends again, pushing the extrusion plate to carry the trehalose dressing precursor into the inner side of the container. The extrusion plate stops when it reaches its limit position, and the drive motor starts in reverse, driving the driven gear to rotate the carrier frame 180° in the opposite direction. The precursor falls into the container, the electric push rod retracts, and the extrusion plate returns to its initial position relative to the carrier frame. When it is necessary to heat and dry the trehalose precursor, the inside of the equipment housing rises, and its internal parts are processed according to the procedures in steps 3, 4, and 5. After the drying of the trehalose dressing precursor is completed, the equipment housing stops and opens, and the finished product is taken out.
[0016] The beneficial effects of this invention are as follows: This invention adopts a combination of a material holding component, an extrusion plate, and a support frame to achieve the effect of flipping a double-sided tray. During the flipping process, the extrusion plate is brought into contact with the trehalose dressing precursor in the material holding component, ensuring the stability of the trehalose dressing precursor during the flipping process. Through the flipping operation, the trehalose dressing precursor is changed from single-sided processing to simultaneous processing on five sides, thereby improving the processing surface area and interfacial mass transfer efficiency. Under the premise of shortening the freeze-drying time, reducing energy consumption, and without changing the size of the equipment, when drying the trehalose dressing precursor, the moisture in the trehalose dressing precursor can be discharged in multiple directions. This physically breaks through the systemic bottleneck of "obstructed water vapor escape, delayed drying, and uneven drying, which leads to long drying time" in traditional unidirectional processing. After the flipping action is completed, the rectangular groove of the hinge plate is exposed by the deformation of all the hollow connecting plates and hinge plates in the same container, providing a precondition for the shaping of the original lower side of the trehalose dressing precursor. Subsequently, the reciprocating deformation of all the hollow connecting plates and hinge plates in the same container brings the original upper side of the trehalose dressing precursor into contact with all the hollow connecting plates and hinge plates in the same container, so as to facilitate the separation of the original lower side of the trehalose dressing precursor and provide a precondition for the subsequent five-sided processing. Attached Figure Description
[0017] Figure 1 This is a three-dimensional structural diagram of the present invention; Figure 2 This is a three-dimensional structural diagram of the support frame of the present invention; Figure 3 This is a three-dimensional structural diagram showing the positional relationship between the support frame and the material container of the present invention; Figure 4 This is a three-dimensional structural diagram showing the positional relationship between the support frame and the material container of the present invention from another perspective; Figure 5 This is a three-dimensional structural diagram of the fixed gear, transmission gear, and driven gear of the present invention; Figure 6 This is an exploded view of the support frame and support shaft of the present invention; Figure 7 This is a three-dimensional structural diagram of the electric push rod and U-shaped frame of the present invention; Figure 8 This is an exploded view of the extrusion plate and U-shaped frame of the present invention; Figure 9 This is a three-dimensional sectional view of the extrusion plate of the present invention; Figure 10 For the present invention Figure 8 Enlarged view of point A in the middle; Figure 11 This is a three-dimensional structural diagram of the hollow connecting plate and hinge plate of the present invention; Figure 12This is an exploded view of the hollow connecting plate and hinge plate of the present invention; Figure 13 This is a three-dimensional structural diagram of the driving module of the present invention; Figure 14 This is a three-dimensional structural diagram of the drive motor and transmission shaft of the present invention.
[0018] The components in the diagram are labeled as follows: 1-Equipment housing, 2-Support frame, 3-Support shaft, 301-Drive motor, 302-Transmission shaft, 4-Rotating frame, 401-Fixed gear, 402-Transmission gear, 403-Driven gear, 5-Drive module, 6-Bearing frame, 7-Material holder, 701-Hollow connecting plate, 702-Hinge plate, 703-Tension spring, 8-Extrusion plate, 9-Electric push rod, 10-U-shaped frame, 11-First elastic telescopic rod, 12-Fixed frame, 13-Second spring telescopic rod, 14-Extrusion seat, 15-Pry bar. Detailed Implementation
[0019] The present invention will be further described below with reference to the embodiments shown in the accompanying drawings.
[0020] To address the technical problem in existing freeze-drying processes where the tray obstructs the flow of water vapor from the water treatment process on the upper part of the trehalose dressing precursor, leading to delayed and uneven drying and consequently long drying times, this invention transforms the trehalose dressing precursor from an initial single-sided processing state to a five-sided simultaneous processing state through a flipping operation. During the flipping process, controlled adhesion is used to suppress arbitrary deformation and slippage of the trehalose dressing precursor, thereby providing balanced heat and mass transfer conditions without shortening freeze-drying time, reducing energy consumption, or altering the equipment volume.
[0021] Example 1
[0022] A trehalose dressing freeze dryer, such as Figures 1-9 and Figure 13 As shown, the device includes a housing 1, a support frame 2 inside the housing 1, a support shaft 3 fixedly connected to the support frame 2, two rotating frames 4 rotatably connected to the support shaft 3, a drive module 5 for driving the rotating frames 4 to rotate on the support shaft 3, a bearing frame 6 distributed in a ring array rotatably connected between the two rotating frames 4, a material holding component 7 detachably connected to the bearing frame 6, a number of evenly distributed telescopic sleeves inside the material holding component 7, and an extrusion plate 8 for supporting the material inside the material holding component 7 on the bearing frame 6.
[0023] In the above scheme, a control terminal is provided on the left side of the equipment housing 1. All electrical components mentioned in this invention are electrically connected to the control terminal. The drive module 5 consists of a single-axis motor and a gear set. The gear set is mounted on the single-axis motor and the rotating frame 4. In actual use, there can be two drive modules 5, which are distributed on the front and rear sides of the support shaft 3 to drive the two rotating frames 4 to rotate synchronously. (See reference...) Figure 8 The two parts on the lower side of the support frame 6 are clips for fixing the material container 7. The material container 7 is fixed to the support frame 6 by these clips. In the initial stage, the trehalose dressing precursor is laid flat in the material container 7, with only the top surface exposed to the vacuum cavity. At this time, it is a "single-sided processing" mode, which is mainly to shape the upper side of the trehalose dressing precursor and prepare for subsequent flipping. After the upper side of the trehalose dressing precursor is shaped, the extrusion plate 8 moves towards the material container 7 to adhere to the trehalose dressing precursor and flips it 180°. After flipping, the material container 7 moves away from the extrusion plate 8, and the trehalose dressing precursor is flipped over and placed on the extrusion plate 8. On plate 8, the five sides of the trehalose dressing precursor, except for the bottom surface that contacts the extrusion plate 8, are released from constraint and then come into contact with the vacuum chamber. This is the "five-sided processing" mode. This method improves the processing surface area and interfacial mass transfer efficiency. Under the premise of shortening the freeze-drying time, reducing energy consumption, and without changing the size of the equipment, the water in the trehalose dressing precursor can be discharged in multiple directions when drying the trehalose dressing precursor. This physically breaks through the systemic bottleneck of "obstructed water vapor escape, delayed drying, and uneven drying leading to long drying time" in traditional unidirectional processing.
[0024] like Figures 7-9 As shown, an electric push rod 9 is provided on the side of the bearing frame 6 away from the material holding part 7. The telescopic end of the electric push rod 9 is fixedly connected to a U-shaped frame 10 that is slidably connected to the bearing frame 6. Several first elastic telescopic rods 11 are fixedly connected on the side of the U-shaped frame 10 away from the electric push rod 9. The telescopic ends of the several first elastic telescopic rods 11 are all fixedly connected to the extrusion plate 8. An arc-shaped plate is fixedly connected to the outer edge of the extrusion plate 8.
[0025] In the above scheme, the arc plate at the outer edge of the extrusion plate 8 is used to prevent the material from leaking outward after collapsing. The electric push rod 9 is used to drive the extrusion plate 8 to move back and forth. When the telescopic part of the electric push rod 9 extends, it moves through the U-shaped frame 10 and the first elastic telescopic rod 11 to drive the extrusion plate 8 to move towards the material holding part 7. The size of the extrusion plate 8 is consistent with the inner size of the material holding part 7.
[0026] like Figure 5 , Figure 6 , Figure 13 and Figure 14As shown, fixed gears 401 are rotatably connected to both sides of the support shaft 3, and a transmission gear 402 distributed in a ring array is rotatably connected to the rotating frame 4. The transmission gears 402 distributed in the ring array mesh with the adjacent fixed gears 401. The transmission gears 402 correspond one-to-one with the bearing frame 6. The bearing frame 6 is rotatably connected to the driven gear 403, and the driven gear 403 meshes with the corresponding transmission gear 402.
[0027] In the above scheme, the number of teeth and the module of the fixed gear 401 and the driven gear 403 are the same, the number of teeth of the transmission gear 402 is less than that of the driven gear 403, but the module of the transmission gear 402 is the same as that of the driven gear 403.
[0028] like Figure 9 , Figure 11 and Figure 12 As shown, the telescopic sleeve is composed of a hollow connecting plate 701, a hinge plate 702, and a tension spring 703. The hollow connecting plate 701 and the hinge plate 702 are fixedly connected, and the tension spring 703 is fixed between the hollow connecting plate 701 and the hinge plate 702. The hinge plate 702 in one side of the telescopic sleeve in the same material holding component 7 is hinged to the material holding component 7, and the hollow connecting plate 701 in the other side of the telescopic sleeve in the same material holding component 7 is hinged to the material holding component 7. The hollow connecting plates 701 and the hinge plates 702 on two adjacent telescopic sleeves are hinged to each other. The hinge plate 702 is provided with a rectangular groove, which is used to provide a channel for gas discharge. A fixed frame 12 is fixedly connected to the side of the bearing frame 6 away from the electric push rod 9. The fixed frame 12 is fixedly connected to a second spring telescopic rod 13. The telescopic end of the second spring telescopic rod 13 is fixedly connected to a pressing seat 14, which is used to press the adjacent hollow connecting plate 701.
[0029] In the above scheme, the tension spring 703 can be an elastic paddle, and the tension spring 703 is initially in a stretched and stored state to ensure the straightness of the hollow connecting plate 701 and the hinge plate 702. When the extrusion seat 14 extrudes the hollow connecting plate 701 located in the middle, all the hollow connecting plates 701 and hinge plates 702 in the same material holding part 7 deform upward from the middle and are arc-shaped as a whole. Through the deformation of all the hollow connecting plates 701 and hinge plates 702 in the same material holding part 7, the rectangular groove of the hinge plate 702 is exposed so that the trehalose dressing precursor between the material holding part 7 and the extrusion plate 8 can contact the vacuum cavity. After the trehalose dressing precursor originally located on the lower side of the material holding part 7 is freeze-dried, all the hollow connecting plates 701 and hinge plates 702 in the same material holding part 7 continue to deform so that the trehalose dressing precursor can fall onto the upper side of the extrusion plate 8.
[0030] like Figures 7-10As shown, the fixed frame 12 is hinged with two rocker arms 15, the extrusion seat 14 is provided with two pairs of sliding grooves, the side of the rocker arm 15 near the extrusion seat 14 is slidably connected to one of the pairs of sliding grooves, the U-shaped frame 10 is used to extrude the two rocker arms 1, the support shaft 3 is provided with a drive motor 301, the drive motor 301 is fixedly connected to a transmission shaft 302, and the transmission shaft 302 is connected to a fixed gear 401 for transmission.
[0031] In the above scheme, the U-shaped frame 10 presses the outer sides of the two rocker arms 15, causing the two rocker arms 15 to rotate along the fixed frame 12 and lift the pressing seat 14 upward, so as to provide the driving force to press all the hollow connecting plates 701 and hinge plates 702 in the same material container 7. The drive motor 301 is a dual-shaft self-locking motor. In this invention, there are two transmission shafts 302. The two transmission shafts 302 are respectively fixed to the two drive shafts of the drive motor 301. The end of the transmission shaft 302 away from the drive motor 301 is fixed to a drive gear for driving the fixed gear 401 to rotate. The drive gear is used to intermittently transmit the driven gear 403 through the fixed gear 401 and the transmission gear 402, so that the driven gear 403 drives the bearing frame 6 to rotate relative to the horizontal plane.
[0032] Working principle: Taking the removal and installation of one of the carrier frames 6 as an example, before the trehalose dressing precursor needs to be freeze-dried, the user removes the two clips on the carrier frame 6, and then removes the holding part 7 and its parts. The user then installs the trehalose dressing precursor into the holding part 7 (that is, on the top of all the hollow connecting plates 701 and hinge plates 702 in the same holding part 7, and during this process, the weight of the trehalose dressing precursor is not enough to deform all the hollow connecting plates 701 and hinge plates 702 in the same holding part 7), and then reassembles the holding part 7 containing the trehalose dressing precursor onto the carrier frame 6.
[0033] Once all the container parts 7 are assembled, the user controls the equipment housing 1 to seal it. The equipment housing 1 creates a freeze-drying environment for the trehalose dressing precursor inside. At the same time, the drive module 5 drives the rotating frame 4 to rotate. During the rotation of the two rotating frames 4, all the container parts 7 and their parts rotate synchronously. Under the meshing action of the fixed gear 401, the transmission gear 402 and the driven gear 403 (based on the principle of existing planetary gear sets), the container parts 7 and their parts move horizontally along with all the rotating frames 4, achieving the effect of actively driving the container parts 7 and their parts to move continuously in a horizontal state, thus ensuring the stability of the freeze-drying process of the trehalose dressing precursor.
[0034] After the upper side of the trehalose dressing precursor has been initially frozen relative to the lower side, the telescopic part of the electric push rod 9 drives the U-shaped frame 10 to move downward along the support frame 6 (taking the movement state of a part on one of the support frames 6 as an example, but in use all the telescopic parts of the electric push rod 9 are extended). The U-shaped frame 10 drives the extrusion plate 8 to move through the first elastic telescopic rod 11. During the movement, the extrusion plate 8 is inserted into the adjacent material container 7. After the extrusion plate 8 moves to the lower side and approaches the upper side of the trehalose dressing precursor, the outer periphery of the extrusion plate 8 has moved to the limit position and is in contact with the upper side of the material container 7 (the extrusion plate 8 can no longer move downward, and the U-shaped frame 10 at this time...). (With the two rocker arms 15 in contact), the telescopic part of the electric push rod 9 continues to drive the U-shaped frame 10 to move downward. The first elastic telescopic rod 11 retracts after being compressed. During the continued movement of the U-shaped frame 10, it squeezes the outer side of the two rocker arms 15, causing the two rocker arms 15 to swing along the fixed frame 12 and lift the extrusion seat 14 upward (during the upward lifting of the extrusion seat 14, the telescopic part of the second spring telescopic rod 13 is pulled). Through the upward movement of the extrusion seat 14, the adjacent hollow connecting plates 701 are squeezed, thereby causing all the hollow connecting plates 701 and hinge plates 702 in the same material container 7 to deform upward from the middle and form an arc shape as a whole (during this process, the tension spring 703 is stretched).
[0035] As the hollow connecting plate 701 and the hinge plate 702 slide relative to each other, the rectangular groove of the hinge plate 702 is exposed so that the trehalose dressing precursor between the material holding part 7 and the extrusion plate 8 comes into contact with the vacuum cavity. At this time, the telescopic part of the electric push rod 9 stops extending. Then, the drive motor 301 drives the drive gear to rotate through the two transmission shafts 302. The drive gear drives the fixed gear 401, causing the fixed gear 401 to rotate along the support shaft 3. The fixed gear 401 transmits power to the driven gear 403 through the transmission gear 402, causing the driven gear 403 to drive the corresponding material holding part 7 and its parts to rotate relative to the horizontal plane. When the container 7 rotates 180°, the drive motor 301 stops and returns to self-locking. The fixed gear 401 then stops rotating, restoring the previous planetary gear set transmission mode of the fixed gear 401, transmission gear 402, and driven gear 403. The original lower side of the trehalose dressing precursor is now converted to the upper side. After the upper side is freeze-dried and shaped, the telescopic part of the electric push rod 9 continues to extend. The extrusion force applied to the pry bar 15 by the U-shaped frame 10 causes the pry bar 15 to continue to extrude adjacent hollow connecting plates 701 through the extrusion seat 14. This increases the degree of arc deformation of all hollow connecting plates 701 and hinge plates 702 in the same container 7, causing the trehalose dressing precursor to... Actively disengaging from all hollow connecting plates 701 and hinge plates 702 within the same holding component 7, the following effects are achieved through the above-described working process: First, by extruding the plate 8 into contact with the original upper side of the trehalose dressing precursor, the trehalose dressing precursor is covered both above and below. Then, by rotating the support frame 6 and its auxiliary parts 180°, the trehalose dressing precursor is flipped over, protecting it during the flipping process. Subsequently, by extruding the original lower side of the trehalose dressing precursor through all hollow connecting plates 701 and hinge plates 702 within the same holding component 7, the trehalose dressing precursor falls off.
[0036] When the trehalose dressing precursor falls onto the extrusion plate 8, the telescopic part of the electric push rod 9 retracts, and the U-shaped frame 10 moves back to its original position and no longer extrudes the two rocker arms 15 (the telescopic part of the first elastic telescopic rod 11 is released). The second spring telescopic rod 13 drives the extrusion seat 14 to move back to its original position. After the extrusion seat 14 stops extruding the adjacent hollow connecting plates 701, all the hollow connecting plates 701 and hinge plates 702 in the same material holding component 7 are reset under the action of the adjacent tension springs 703, from an arc shape until they are reset to a straight state. Through the reset of all the hollow connecting plates 701 and hinge plates 702 in the same material holding component 7, the trehalose dressing is no longer in contact with them. After the extension and retraction of the first elastic telescopic rod 11 is released, the U-shaped frame 10 drives the extrusion plate 8 to move and reset through the first elastic telescopic rod 11. After the extrusion plate 8 moves to the initial position, the extension and retraction of the electric push rod 9 stops moving. Through the above working process, the following effect is achieved: the trehalose dressing precursor is flipped and placed on the extrusion plate 8, so that the trehalose dressing precursor, except for the bottom surface that contacts the extrusion plate 8, is changed from single-sided processing to simultaneous processing of five sides, thereby improving the processing surface area and interfacial mass transfer efficiency.
[0037] After the low-temperature drying of the trehalose dressing precursor meets the required working time, the telescopic part of the electric push rod 9 extends, causing the extrusion plate 8 to carry the trehalose dressing precursor into the holding container 7. When the extrusion plate 8 moves to its limit position, the electric push rod 9 stops working. Then, the drive motor 301 drives the fixed gear 401 through the transmission shaft 302, which in turn drives the driven gear 403 through the transmission gear 402. This causes the driven gear 403 to drive the support frame 6 to rotate 180° in the opposite direction. After the support frame 6 has rotated 180° in the opposite direction, the drive motor 301 stops working, and the trehalose dressing precursor falls into the holding container 7. Finally, the telescopic part of the electric push rod 9 retracts, causing the extrusion plate 8 to move back to its initial position relative to the support frame 6.
[0038] When the trehalose dressing precursor needs to be heated and dried, the internal temperature of the equipment housing 1 rises, and its internal parts are processed according to the low-temperature drying procedure. The subsequent process of turning the trehalose dressing over is also processed according to the low-temperature drying procedure. After the drying of the trehalose dressing precursor is completed, the user stops the operation of the equipment housing 1, opens the equipment housing 1, and takes out the trehalose dressing precursor.
[0039] To facilitate the removal of the trehalose dressing precursor, the present invention can also be configured as follows: the first elastic telescopic rod 11 is detachably connected to the extrusion plate 8, so that the extrusion plate 8 can be directly removed before the freeze-drying of the trehalose dressing precursor is completed and before the support frame 6 is rotated and reset.
[0040] Example 2
[0041] Based on Example 1, a method for using a trehalose dressing freeze dryer is provided, such as... Figures 1-14 As shown, based on a trehalose dressing freeze dryer, the specific steps are as follows: Step 1: Material preparation: Remove the material container 7 from the support frame 6, lay the trehalose dressing precursor flat on the inside of the material container 7, and then reassemble the material container 7 onto the support frame 6. Step 2: Low-temperature drying start-up and rotation: After all the material holding parts 7 are assembled, the equipment shell 1 is closed. The equipment shell 1 is evacuated and cooled to form a freeze-drying environment. The drive module 5 is started and drives the rotating frame 4 to rotate. All rotating frames 4 drive all the bearing frames 6 to rotate synchronously. Through the planetary gear set composed of fixed gear 401, transmission gear 402 and driven gear 403, each bearing frame 6 and its auxiliary parts are kept horizontal during the revolution. Step 3: Triggering flipping after initial freezing: After the upper side of the trehalose dressing precursor is initially frozen, the telescopic part of the electric push rod 9 extends, causing the U-shaped frame 10 to move downward along the bearing frame 6. The U-shaped frame 10 drives the extrusion plate 8 downward through the first elastic telescopic rod 11, inserts into the adjacent material container 7 and fits with it. When the bottom surface of the extrusion plate 8 fits with the upper side of the precursor, the U-shaped frame 10 continues to move downward and contacts the outside of the rocker arm 15, causing the rocker arm 15 to swing around the fixed frame 12, raising the extrusion seat 14 to extrude the adjacent hollow connecting plate 701, forcing all the hollow connecting plates 701 and hinge plates 702 in the same material container 7 to undergo elastic deformation from the middle, forming an arc shape as a whole, and the tension spring 703 stretches synchronously. Step 4: 180° flipping action: When all the hollow connecting plates 701 and hinge plates 702 in the same holding component 7 undergo elastic deformation from the middle until the rectangular groove of the hinge plate 702 is exposed, the extension part of the electric push rod 9 stops extending, the drive motor 301 starts, and drives the fixed gear 401 to rotate via the transmission shaft 302. The fixed gear 401 drives the corresponding holding component 7 to rotate relative to the horizontal plane through the transmission gear 402 and the driven gear 403. After the holding component 7 completes the 180° rotation, the drive motor 301 stops. At this time, the original lower side of the precursor body turns to the upper side and is in a frozen and shaped state. Then the electric push rod 9 continues to extend, increasing the squeezing force on the rocker arm 15, causing the squeezing seat 14 to be further raised, and intensifying the deformation degree of the hollow connecting plate 701 and hinge plate 702. Step 5: Flipping and detachment: The intensified arc deformation causes the trehalose dressing to detach from the hollow connecting plate 701 and the hinge plate 702 and fall onto the extrusion plate 8. Subsequently, the telescopic part of the electric push rod 9 retracts, the U-shaped frame 10 moves upward to reset, and the hollow connecting plate 701 and the hinge plate 702 gradually return to straight under the action of the tension spring 703. The extrusion plate 8 resets and moves to the initial position. Step 6: Reset and Start Heating and Drying: After the low-temperature drying process is completed, the electric push rod 9 extends again, pushing the extrusion plate 8 to carry the trehalose dressing precursor into the inner side of the container 7. The extrusion plate 8 stops at its limit position, and the drive motor 301 starts in reverse, driving the driven gear 403 to rotate the carrier frame 6 180° in the opposite direction. The precursor falls into the container 7, the electric push rod 9 retracts, and the extrusion plate 8 returns to its initial position relative to the carrier frame 6. When it is necessary to heat and dry the trehalose precursor, the inside of the equipment housing 1 is raised, and its internal parts are processed according to the procedures of steps 3, 4, and 5. The subsequent process of turning the trehalose dressing over is all processed according to the low-temperature drying procedure. After the drying of the trehalose dressing precursor is completed, the equipment housing 1 is stopped and opened, and the finished product is taken out.
[0042] The above embodiments are only for illustrating the technical concept and features of the present invention, and are intended to enable those skilled in the art to understand the content of the present invention and implement it accordingly. They should not be construed as limiting the scope of protection of the present invention. All equivalent changes or modifications made in accordance with the spirit and essence of the present invention should be covered within the scope of protection of the present invention.
Claims
1. A trehalose dressing freeze dryer, comprising a housing (1), wherein a support frame (2) is disposed within the housing (1), characterized in that, It also includes a support shaft (3), which is fixed to the support frame (2). The support shaft (3) is rotatably connected to two rotating frames (4). The support shaft (3) is provided with a drive module (5) for driving the rotating frames (4) to rotate. The two rotating frames (4) are rotatably connected to a bearing frame (6) distributed in a ring array. The bearing frame (6) is detachably connected to a material holding component (7). The material holding component (7) is provided with several telescopic sleeves evenly distributed inside. The bearing frame (6) is provided with an extrusion plate (8) for supporting the material inside the material holding component (7). An electric push rod (9) is provided on the side of the bearing frame (6) away from the material container (7). The telescopic end of the electric push rod (9) is fixedly connected to a U-shaped frame (10) that is limited and slidably connected to the bearing frame (6). A plurality of first elastic telescopic rods (11) are fixedly connected on the side of the U-shaped frame (10) away from the electric push rod (9). The telescopic ends of the plurality of first elastic telescopic rods (11) are all fixedly connected to the extrusion plate (8). The telescopic sleeve is composed of a hollow connecting plate (701), a hinge plate (702), and a tension spring (703). The hollow connecting plate (701) is fixed to the hinge plate (702), and the tension spring (703) is fixed between the hollow connecting plate (701) and the hinge plate (702). The hinge plate (702) in one side of the telescopic sleeve in the same material holding component (7) is hinged to the material holding component (7), and the hollow connecting plate (701) in the other side of the telescopic sleeve in the same material holding component (7) is hinged to the material holding component (7). The hollow connecting plates (701) and the hinge plates (702) that are close to each other on two adjacent telescopic sleeves are hinged to each other. The hinge plate (702) is provided with a rectangular groove for providing a channel for gas discharge; A fixed frame (12) is fixedly connected to the side of the bearing frame (6) away from the electric push rod (9). A second spring telescopic rod (13) is fixedly connected to the fixed frame (12). A pressing seat (14) is fixedly connected to the telescopic end of the second spring telescopic rod (13). The pressing seat (14) is used to press the adjacent hollow connecting plate (701). The fixed frame (12) is hinged with two rocker arms (15), the extrusion seat (14) is provided with two pairs of sliding grooves, and the rocker arm (15) is slidably connected to one of the pairs of sliding grooves on the side near the extrusion seat (14). The U-shaped frame (10) is used to extrude the two rocker arms (15).
2. The trehalose dressing freeze dryer according to claim 1, characterized in that, An arc-shaped plate is fixed to the outer edge of the extrusion plate (8).
3. The trehalose dressing freeze dryer according to claim 2, characterized in that, Fixed gears (401) are rotatably connected to both sides of the support shaft (3). The rotating frame (4) is rotatably connected to a transmission gear (402) arranged in a ring array. The transmission gears (402) arranged in a ring array mesh with the adjacent fixed gears (401). The transmission gears (402) correspond one-to-one with the bearing frame (6). The bearing frame (6) is rotatably connected to a driven gear (403). The driven gear (403) meshes with the corresponding transmission gear (402).
4. The trehalose dressing freeze dryer according to claim 3, characterized in that, The support shaft (3) is equipped with a drive motor (301), and the drive motor (301) is fixedly connected to a transmission shaft (302). The transmission shaft (302) is connected to the fixed gear (401) for transmission.
5. A method of using a trehalose dressing freeze dryer, wherein the trehalose dressing freeze dryer according to claim 4 is characterized in that, The specific steps are as follows: Step 1: Material preparation: Remove the material container (7) from the support frame (6), lay the trehalose dressing precursor flat on the inside of the material container (7), and then reassemble the material container (7) onto the support frame (6); Step 2: Low temperature drying start-up and rotation: After all the material holding parts (7) are assembled, the equipment shell (1) is closed. The equipment shell (1) is evacuated and cooled to form a freeze-drying environment. The drive module (5) is started and drives the rotating frame (4) to rotate. All rotating frames (4) drive all the bearing frames (6) to rotate synchronously. Through the planetary gear set composed of fixed gear (401), transmission gear (402) and driven gear (403), each bearing frame (6) and its auxiliary parts are kept horizontal during the revolution. Step 3: Triggering flipping after initial freezing: After the initial freezing of the trehalose dressing precursor is completed, the telescopic part of the electric push rod (9) extends, causing the U-shaped frame (10) to move downward along the bearing frame (6). The U-shaped frame (10) drives the extrusion plate (8) to move downward through the first elastic telescopic rod (11), inserts into the adjacent material container (7) and fits with it. The U-shaped frame (10) continues to move downward and contacts the outside of the rocker arm (15), causing the rocker arm (15) to swing around the fixed frame (12) and lift the extrusion seat (14) to extrude the adjacent hollow connecting plate (701), forcing all the hollow connecting plates (701) and hinge plates (702) in the same material container (7) to undergo elastic deformation from the middle, forming an arc shape. The tension spring (703) stretches synchronously. Step 4: 180° flipping action execution: When all the hollow connecting plates (701) and hinge plates (702) in the same material container (7) undergo elastic deformation from the middle to the point that the rectangular groove of the hinge plate (702) is exposed, the extension part of the electric push rod (9) stops extending, the drive motor (301) starts, and drives the fixed gear (401) to rotate via the transmission shaft (302). The fixed gear (401) drives the corresponding material container (7) to rotate relative to the horizontal plane through the transmission gear (402) and the driven gear (403). After the material container (7) completes the 180° rotation, the drive motor (301) stops. At this time, the original lower side of the precursor body turns to the upper side and is in a frozen and shaped state. Then the electric push rod (9) continues to extend, increasing the squeezing force on the rocker arm (15), causing the squeezing seat (14) to be further raised, which intensifies the deformation degree of the hollow connecting plate (701) and hinge plate (702). Step 5: Flipping and detachment: The intensified arc deformation causes the trehalose dressing to detach from the hollow connecting plate (701) and hinge plate (702) and fall onto the extrusion plate (8). Subsequently, the telescopic part of the electric push rod (9) retracts, the U-shaped frame (10) moves upward to reset, and the hollow connecting plate (701) and hinge plate (702) gradually return to straight under the action of the tension spring (703). The extrusion plate (8) resets and moves to the initial position. Step 6: Reset and start heating and drying: After the low temperature drying process is completed, the electric push rod (9) extends again, pushing the extrusion plate (8) to carry the trehalose dressing precursor into the inner side of the container (7). The extrusion plate (8) stops at the limit position, and the drive motor (301) starts in reverse, driving the driven gear (403) to drive the carrier frame (6) to rotate 180° in the opposite direction. The precursor falls into the container (7), the electric push rod (9) retracts, and the extrusion plate (8) returns to the initial position relative to the carrier frame (6). When it is necessary to heat and dry the trehalose precursor, the inside of the equipment housing (1) is raised, and its internal parts are processed according to the procedures of the third, fourth and fifth steps. After the drying of the trehalose dressing precursor is completed, the equipment housing (1) is stopped and opened, and the finished product is taken out.