一种位于11号染色体上与猪血清肌酐含量异常相关的SNP分子标记及应用
By discovering and applying the G/A mutant SNP molecular marker located on chromosome 11 in Wuzhishan pigs, the genetic improvement problem of serum creatinine content in Wuzhishan pigs has been solved, enabling early and precise trait selection, reducing the incidence of abnormalities, and improving breeding efficiency and economic benefits.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SANYA RESEARCH INSTITUTE OF HAINAN ACADEMY OF AGRICULTURAL SCIENCES (HAINAN EXPERIMENTAL ANIMAL RESEARCH CENTER)
- Filing Date
- 2026-04-21
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies lack molecular markers that can be directly applied to the genetic improvement of serum creatinine content in Wuzhishan pigs, resulting in low breeding efficiency and difficulty in achieving early and precise trait selection.
We discovered and validated a SNP molecular marker that is associated with abnormal serum creatinine levels in Wuzhishan pigs: the G/A mutation located at 68,587,544 bp on chromosome 11 of the International Pig Reference Genome Version 11.1. We then used primer pairs and probes to detect the mutation and combined it with marker-assisted breeding methods to eliminate individuals with the GA genotype and select individuals with the AA genotype.
This method enables early and precise screening of abnormal serum creatinine levels in Wuzhishan pigs, reducing the incidence of abnormalities, improving breeding efficiency and economic benefits, and enhancing the health and production performance of pigs.
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