A progressive pathological animal model for drug evaluation and a method for constructing the same

By constructing a progressive pathological animal model through a sequential three-stage synergistic induction method, the problem of inaccurate simulation of the T2DM-CRS course in existing technologies has been solved, achieving a high model success rate, low individual variability, and low mortality rate, thereby improving the accuracy and reliability of drug evaluation.

CN122074448BActive Publication Date: 2026-07-21GUANGDONG LAIDI BIOMEDICAL RES INST CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
GUANGDONG LAIDI BIOMEDICAL RES INST CO LTD
Filing Date
2026-04-22
Publication Date
2026-07-21

AI Technical Summary

Technical Problem

The existing technology lacks animal models that can accurately simulate the progressive natural course of type 2 diabetes mellitus complicated with cardiorenal syndrome (T2DM-CRS) in humans. The modeling rate is low, individual differences are large, mortality is high, the course of the disease is uncontrollable, and the fit with clinical practice is low, resulting in poor consistency between preclinical evaluation results and clinical trial results during drug development.

Method used

A sequential three-stage synergistic induction method was adopted to gradually induce insulin resistance, subclinical cardiorenal damage, and progressive fibrosis in rats by feeding them with a high-fat, high-fructose, and high-cholesterol diet, injecting them with low-dose streptozotocin, and intermittently injecting them with angiotensin II, thus constructing a progressive pathological animal model.

Benefits of technology

It enables controllable and precise staging of the disease course, reduces individual differences and mortality, improves the model success rate, and the model characteristics are highly consistent with clinical practice, thereby enhancing the accuracy and reliability of drug evaluation and reducing the risk of drug development failure.

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Abstract

The present application relates to a kind of progressive pathological animal model for drug evaluation and its construction method, belong to experimental animal model technical field.For the defects that existing model cannot simulate clinical progressive course, model rate is low, individual difference is big, and the degree of agreement with clinical pathology feature is low, the present application uses sequential three-stage collaborative induction modeling, sequentially completes basic metabolic abnormality, subclinical heart and kidney injury, progressive heart and kidney fibrosis induction, and accurately matches human disease natural course.This method is simple to operate, without complex operation, the model constructed has high model rate, low mortality, good uniformity, and the pathological characteristics are highly consistent with clinical, can be used for the screening of the disease treatment drug, drug efficacy evaluation and mechanism research.
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