Rofecoxib plaster composition, plaster and preparation method thereof

CN122075451APending Publication Date: 2026-05-26BEIJING MINGZE ZHONGHE PHARM RES CO LTD

Patent Information

Authority / Receiving Office: CN · China
Patent Type: Applications(China)
Current Assignee / Owner: BEIJING MINGZE ZHONGHE PHARM RES CO LTD
Filing Date: 2026-04-22
Publication Date: 2026-05-26

AI Technical Summary

Technical Problem

Rofecoxib oral administration can easily cause gastrointestinal irritation, has a short half-life in the body, requires frequent administration, has poor patient compliance, and there are no patch preparations available on the market.

Method used

The rofecoxib patch composition contains rofecoxib, antipruritic agent, penetration enhancer, crosslinking agent, cooling agent, preservative, acidifier, humectant and thickener. It constructs a three-dimensional gel network structure through scientific compounding. The preparation process is simple and suitable for large-scale production.

Benefits of technology

It achieves sustained and stable drug release, has a soft texture, is easy to apply, has moderate peel strength, reduces systemic adverse reactions, increases local drug concentration for pain relief, and enhances medication adherence.

✦ Generated by Eureka AI based on patent content.

Smart Images

Figure SMS_1
Figure SMS_2
Figure SMS_3

Patent Text Reader

Abstract

The embodiment of the invention discloses a rofecoxib plaster composition, a plaster and a preparation method of the rofecoxib plaster composition. The rofecoxib plaster composition is prepared from the following components in percentage by weight: 0.2 to 0.5 percent of rofecoxib, 1 to 3 percent of an anti-pruritus agent, 0.5 to 3 percent of a penetration enhancer, 0.5 to 1.2 percent of a cross-linking agent, 0.2 to 2 percent of a freshener, 0.2 to 2 percent of a preservative, 0.5 to 1.2 percent of an acidity agent, 10 to 35 percent of a humectant, 2 to 25 percent of a tackifier and the balance of a diluent. The rofecoxib plaster composition provided by the invention is stable in structure, balanced in adhesion performance, controllable in drug release and good in safety. The prepared rofecoxib plaster is lasting and stable in drug release and can realize a long-term curative effect; the plaster is soft in texture, proper in initial adhesion and convenient to paste; meanwhile, the peeling strength is moderate, uncovering and pasting are convenient, and the use compliance is excellent. A cold pressing method preparation process is adopted, raw materials and auxiliary materials are mixed separately, glue drying is not needed after pasting, operation is easy and convenient, the production process is short, and the method is suitable for industrial large-scale production.

Need to check novelty before this filing date? Find Prior Art