一种用于挤出式3D打印的脱细胞基质微粒基墨水及其制备方法
By generating hydrogel microlayers on the surface of rigid dECM-MPs, the problem that rigid dECM-MPs cannot be directly used for 3D printing is solved, enabling high-precision printing of highly bioactive dECM microparticles, improving the printability and biological function of the ink, and adapting to the differences in the microenvironment of cartilage and bone tissue.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- CHENGDU MILITARY GENERAL HOSPITAL OF PLA
- Filing Date
- 2026-04-24
- Publication Date
- 2026-07-17
AI Technical Summary
In existing technologies, rigid decellularized matrix microparticles (dECM-MPs) cannot be directly used for extrusion 3D printing due to their lack of viscoelasticity and flowability. Furthermore, high concentrations of these microparticles incorporated into hydrogel inks can lead to clogging of the extrusion outlet and printing discontinuities.
By generating hydrogel microlayers in situ on the surface of rigid dECM-MPs, and using Fe3+ or Ce3+ mediated interfacial ion diffusion crosslinking, a uniform and dense hydrogel microlayer is generated on the surface of dECM-MPs, forming a 3D printing ink with shear-thinning properties.
It achieves high-precision, high-fidelity direct ink writing with highly bioactive dECM microparticles, improves the flexibility and shear resistance of the particles, ensures the printability and biological function of the ink, adapts to the differences in the microenvironment of cartilage and bone tissue, and achieves a high degree of biomimetic adaptation between materials and tissues.
Smart Images
Figure CN122075791B_ABST