A mutant of Wnt3a ligand protein and its application
By making a hydrophobic mutation at amino acid 57 of the Wnt3a protein, the activity of the Wnt signaling pathway was improved, which solved the problem of low Wnt3a protein activity and achieved significant biological effects, applicable to the fields of regenerative medicine and developmental biology.
CN122080167APending Publication Date: 2026-05-26SHANGHAI TECH UNIV
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Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHANGHAI TECH UNIV
- Filing Date
- 2025-11-24
- Publication Date
- 2026-05-26
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Figure CN122080167A_ABST
Abstract
This invention discloses a mutant of the Wnt3a ligand protein and its applications. The amino acid sequence of the mutant, compared with the amino acid sequence shown in SEQ ID NO:1, includes a mutation at amino acid position 57, which is replaced by a hydrophobic amino acid. The mutant of this invention can significantly enhance the activity of the Wnt signaling pathway, and the expression and secretion of Wnt3a are not affected after the mutation.
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