一种动态共价交联双蛋白及其制备方法和应用
The lactoferrin-transferrin complex was constructed using dynamic covalent cross-linking technology, which solved the problem of insufficient stability of the lactoferrin and transferrin complex. It achieved improved stability and enhanced antioxidant function in weakly acidic to weakly alkaline environments, making it suitable for food, health products and drug delivery systems.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- HUAZHONG AGRI UNIV
- Filing Date
- 2026-04-22
- Publication Date
- 2026-07-17
AI Technical Summary
The existing combination of lactoferrin and transferrin is not stable enough and is easily affected by environmental factors. The protein activity may decrease and the bioavailability is limited, making it difficult to achieve stable synergistic enhancement of antibacterial and antioxidant effects.
Lactoferrin-transferrin complex was constructed using dynamic covalent cross-linking technology. Reduced glutathione was used to induce disulfide bond exchange between lactoferrin and transferrin, forming LF-SS-TF dynamic covalently cross-linked dual proteins. The chemical cross-linking method was adopted under mild conditions.
It significantly improves the stability of the protein in weakly acidic to weakly alkaline environments, and the encapsulation efficiency of red yeast rice liposomes is increased to 76.25%. It achieves deep complementarity between the structure and function of the protein, enhances its antioxidant and growth-promoting capabilities, and is suitable for food, health products and drug delivery systems.
Smart Images
Figure CN122080239B_ABST