一种超低剂量相干衍射成像方法和装置

By separating noise components in reciprocal space using principal component analysis, the problem of limited resolution in coherent diffraction imaging under ultra-low exposure doses is solved, achieving high-resolution and robust imaging suitable for imaging in various electromagnetic bands.

CN122084664BActive Publication Date: 2026-07-17HUAZHONG UNIV OF SCI & TECH

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HUAZHONG UNIV OF SCI & TECH
Filing Date
2026-04-24
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing coherent diffraction imaging techniques have limited resolution at ultra-low exposure doses, and noise aliasing leads to a low signal-to-noise ratio, making it difficult to achieve high-resolution reconstruction. Furthermore, existing algorithms cannot effectively handle non-stationary noise and have high computational overhead.

Method used

Principal component analysis is used to separate noise components in reciprocal space. Noise components are constructed separately for each scanning position and correlated by low-dimensional spatial projection to achieve real-time separation and updating of noise, thus avoiding noise interference with the reconstruction process.

Benefits of technology

It significantly improves the resolution and robustness of coherent diffraction imaging systems under ultra-low exposure doses, reduces the need for high-throughput, high-stability light sources and high-performance detectors, shortens imaging time, and is suitable for imaging in various electromagnetic bands.

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Abstract

本申请属于相干衍射成像技术领域,具体公开了一种超低剂量相干衍射成像方法和装置,本申请基于盲源分离策略,利用主成分分析方式处理采集的衍射信号,在倒易空间进行噪声分离和更新,能够将混合噪声能量有效分离到噪声分量中,从而避免其对重构过程的串扰,显著提升了在重构超低曝光剂量下极低信噪比衍射信号时相干衍射成像的收敛稳定性和鲁棒性。同时,本申请针对每个扫描位置单独构建其噪声分量,并将不同位置的噪声分量通过低维空间投影关联在一起,实现了非平稳噪声分离,使其能更有效处理极短波段探测器量子效率低带来的随机噪声,从而在超低曝光剂量下依然能够保持极高的抗噪鲁棒性与重构精度,实现分辨率的有效提升。
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