一种融合深度学习的染色体核型智能分割方法及系统

By integrating deep learning methods with image enhancement and region segmentation techniques, chromosome adhesion regions are screened and segmented, solving the problems of time-consuming, labor-intensive, and subjective manual interpretation in existing technologies, and achieving high accuracy and high stability in chromosome karyotype segmentation.

CN122090448BActive Publication Date: 2026-07-17HUNAN INST OF INFORMATION TECH

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HUNAN INST OF INFORMATION TECH
Filing Date
2026-04-21
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing technologies rely on manual interpretation in chromosome karyotype analysis, which is time-consuming, labor-intensive, and subject to subjective differences. This makes it difficult to meet the clinical needs for high accuracy and stability, especially when faced with complex situations such as chromosome morphological diversity, blurred boundaries, and chromosome adhesion and overlap, where the segmentation accuracy and robustness are insufficient.

Method used

By employing a deep learning-integrated approach, the pixel area and band count of chromosomes are extracted through image enhancement and region segmentation techniques. The structural coverage index is used to screen candidate adhesion regions, and a deep learning segmentation model is combined for refined processing to identify and segment chromosome adhesion regions.

Benefits of technology

It improves the accuracy of chromosome image segmentation, reduces error propagation, enhances the segmentation ability of adhered chromosomes, and achieves higher segmentation precision and stability.

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Abstract

本申请提供了一种融合深度学习的染色体核型智能分割方法及系统,该方法通过对染色体显微图像进行图像增强;基于染色体增强图像进行区域分割,得到多个染色体区域子图;对于任意一个染色体区域子图,提取该染色体区域子图对应的染色体像素面积和显带数量,并根据染色体像素面积和显带数量确定该染色体区域子图的结构覆盖度指标;将结构覆盖度指标与预设的染色体显带分布模型进行比对,对该染色体区域子图进行异常筛选,确定染色体粘连候选区域;基于深度学习分割模型对染色体粘连候选区域进行粘连区域分割,得到对应的染色体核型分割图像,本申请能够根据染色体的骨架显带密度筛选并识别粘连候选区域,提高了染色体图像分割的准确性。
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