A quantitative aerosol containing 4-trifluoromethylnicotinamide and use thereof

Abstract

The present application relates to a kind of quantitative aerosol containing 4-trifluoromethylnicotinamide and application, and quantitative aerosol contains 0.2%~25% active ingredient containing 4-trifluoromethylnicotinamide by weight percentage, and the balance is auxiliary agent;Auxiliary agent is solvent and propellant.The present application is sprayed out by quantitative spray valve, and the amount of spraying can be controlled in 0.05mL~1mL, and has the advantages of fast knockdown speed and high mortality rate to mosquito, fly and other health pests.

Description

Technical Field

[0001] This invention relates to insecticidal compositions, specifically a metered-dose aerosol containing 4-trifluoromethylnicotinamide and its application. Background Technology

[0002] 4-Trifluoromethylnicotinamide is a metabolite of flonicamid and possesses insecticidal activity. It binds to and inhibits nicotinamide enzymes in insects. Nicotinamide enzymes are expressed in spinal cord tension receptor neurons / stringer neurons and are the ninth molecular target in the insect nervous system. Inhibition of nicotinamide enzymes by 4-trifluoromethylnicotinamide leads to the accumulation of the substrate nicotinamide, thereby overactivating TRPV ion channels and producing poisoning symptoms.

[0003] Pyrethroids are low-toxicity, highly effective sanitary pyrethroids. Besides their high insecticidal activity, they also possess suitable vapor pressures, making them suitable for metered-dose aerosol formulations. However, long-term, high-volume use of pyrethroid insecticides has led to increasingly serious resistance among sanitary pests, significantly reducing actual control effectiveness. The post-knockout recovery phenomenon is particularly prominent; although pests are knocked down shortly after exposure to the pesticide, they often recover their activity level later, resulting in a lower final mortality rate and increased difficulty in control. To address these issues, researchers have attempted to enhance efficacy and delay the development of resistance by combining active ingredients with different mechanisms of action. Summary of the Invention

[0004] The technical problem to be solved by the present invention is to address the shortcomings of the prior art by providing a metered aerosol containing 4-trifluoromethylnicotinamide and its application.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: A metered-dose aerosol containing 4-trifluoromethylnicotinamide, wherein, by weight percentage, 0.2% to 25% is the active ingredient of 4-trifluoromethylnicotinamide, and the balance is an auxiliary agent; the auxiliary agent is a solvent and a propellant.

[0006] The active ingredients containing 4-trifluoromethylnicotinamide are active ingredient A and active ingredient B; wherein, active ingredient A is selected from 4-trifluoromethylnicotinamide; and active ingredient B is selected from any one of tetrafluorobenzyl, methoxybenzylflufenoxuron, and tetrafluorobenzylflufenoxuron.

[0007] The metered aerosol contains, by weight percentage, 0.1-5% active ingredient A, 0.1-20% active ingredient B, 1-50% solvent, and the remainder is propellant.

[0008] When the active ingredient B is selected from tetrafluorobenzyl pyrethrin, the mass ratio of active ingredient A to active ingredient B is 10:1 to 1:10. When the active ingredient B is selected from methoxybenzylfluorometholone, the mass ratio of active ingredient A to active ingredient B is 15:1 to 1:10. When the active ingredient B is selected from tetrafluorobenzenepyrethrin, the mass ratio of active ingredient A to active ingredient B is 10:1 to 1:15.

[0009] The solvent is one or more of the following: dimethyl carbonate, dibutyl carbonate, propylene carbonate, dimethyl adipate, diisopropyl adipate, dibutyl adipate, dimethyl succinate, dimethyl glutarate, γ-butyrolactone, isopropyl tridecaate, isopropyl tetradecaate, isopropyl hexadecanoate, tributyl acetyl citrate, propylene glycol methyl ether, propylene glycol phenyl ether, glycerol butyl ether, propylene glycol butyl ether, dipropylene glycol dimethyl ether, cyclohexanediol monomethyl ether, methyl tert-butyl ether, N,N-dimethyldecanoamide, N,N-dimethylacetamide, C8-18 alkane solvents, and C2-8 alcohol solvents.

[0010] The C8-18 alkane solvent is preferably one or more of the following: D60 (ExxonMobil Petrochemicals), D80 (ExxonMobil Petrochemicals), D100 (ExxonMobil Petrochemicals), D110 (ExxonMobil Petrochemicals), Isopar-E (ExxonMobil Petrochemicals), Isopar-G (ExxonMobil Petrochemicals), Isopar-H (ExxonMobil Petrochemicals), Isopar-L (ExxonMobil Petrochemicals), Isopar-M (ExxonMobil Petrochemicals), octane, nonane, quinane, undecane, dodecane, tridecane, tetradecane, pentadecane, and hexadecane.

[0011] The preferred C2-8 alcohol solvents are one or more of the following: ethanol, isopropanol, n-propanol, n-butanol, sec-butanol, tert-butanol, n-pentanol and its isomers, n-hexanol and its isomers, n-heptanol and its isomers, and n-octanol and its isomers.

[0012] The propellant is one of liquefied petroleum gas, propane, dimethyl ether, or compressed air.

[0013] The metered aerosol can be supplemented with one or more of the following: synergists (such as PBO), fragrances, and antioxidants (such as BHA, BHT, etc.) as needed.

[0014] A method for preparing a metered aerosol containing 4-trifluoromethylnicotinamide involves mixing active ingredient A, active ingredient B, and solvent at 30–50°C according to the above proportions, adding the mixture to a spray can equipped with a metered spray valve, and adding propellant to the spray can under pressure to obtain a metered aerosol.

[0015] An application of the aforementioned metered-dose aerosol containing 4-trifluoromethylnicotinamide, specifically its application in the control of public health pests.

[0016] The sanitary pests mentioned are one or more of the following: mosquitoes, flies, bedbugs, and fleas.

[0017] Further, this refers to species such as Culex pipiens pallens, Culex tritaeniorhynchus, Aedes albopictus, Aedes aegypti, Anopheles sinensis, Aedes harassing, midges, houseflies, house flies, golden flies, greenbottle flies, copper green flies, bright green flies, summer toilet flies, bed bugs, fleas, etc.

[0018] The public places mentioned are one or more of the following: schools, residences, restaurant private rooms, hotels, and shopping malls.

[0019] When the aforementioned metered-dose aerosol insecticidal composition is used to control sanitary pests in public places, it is applied by spraying once or multiple times into a specific space using a metered-dose spray valve. The number of sprays is determined based on the size of the space, with an average spray area of ​​15m. 3 Spray once.

[0020] The aforementioned sanitary pests, and the metered aerosol of this invention, when used: opening the metered spray valve, under the pressure of the propellant, generates a high-speed airflow, utilizing the vaporization energy of the propellant to disperse and atomize the active ingredient liquid in the aerosol can into droplets; after being sprayed into space, the sprayed droplets can quickly disperse and diffuse in the space, remaining in the space for 1-2 hours without touching the ground, exhibiting good rapid effect; moreover, the droplets can adhere to ceilings, walls, floors, etc., exhibiting good long-lasting effect.

[0021] Compared with existing technologies, it has the following characteristics: This invention proposes a combination of 4-trifluoromethylnicotinamide and a specific pyrethroid. This combination aims to enhance the killing effect on sanitary pests through synergistic action, while effectively slowing down the development of pesticide resistance, providing a more durable and efficient chemical control method for integrated pest management; specifically: (1) The combination of 4-trifluoromethylnicotinamide and pyrethroids in quantitative aerosols ensures both rapid and sustained effects, and significantly improves the lethality of sanitary pests. (2) It has a significant synergistic effect when combined with pyrethroids, thus reducing the dosage. (3) Compared with existing conventional aerosols, the dosage of metered spray is relatively small, and less solvent is sprayed, making it safer for the environment and human body; (4) The number of sprays can be customized according to the size of the space, such as one spray can reach 15m. 3 Space protection effectiveness, 30m 3 The space only needs to be sprayed once at each diagonal point to achieve the desired protective effect; (5) Conventional aerosol sprays require at least 30 minutes to be used before entering the room after the windows and doors are opened for ventilation. However, the quantitative aerosol spray method described in this invention does not require this. After spraying the spray, people can stay indoors. Therefore, this invention is safer for human health. Detailed Implementation

[0022] The following describes in detail the specific embodiments of the technical solution of the present invention, but the present invention is not limited to the following description.

[0023] This invention relates to a metered-dose aerosol insecticide containing 4-trifluoromethylnicotinamide. Its active ingredients are 4-trifluoromethylnicotinamide and a specific pyrethroid, wherein the pyrethroid includes any one of tetrafluorobenzyl, methoxybenzylflupyr, and tetrafluorobenzylpyrethrin. A metered-dose aerosol is prepared using the above as the active ingredients. The aerosol is sprayed meteredly into the space through a metered-dose spray valve, resulting in more uniform dispersion, improved rapid and sustained efficacy, and ease of use (requiring only one or several presses, eliminating the need to consider pressing time). This reduces the amount of formulation required, ultimately achieving the goal of controlling sanitary pests.

[0024] The preparation method in the following formulation examples is as follows: 4-trifluoromethylnicotinamide, pyrethroids and solvents in the specified proportions are mixed at 40°C and added to a 100ml spray can. A 0.5mL metering spray valve is installed, and propellant is injected into the can to make up to 50g. After thorough shaking, the spray can is fitted with a nozzle to obtain a metered aerosol.

[0025] The present invention will now be described in conjunction with specific embodiments: Formulation Example 1: 5.5% 4-Trifluoromethylnicotinamide·Tetrafluorobenzenepyrethrin Metered-Count Aerosol 2.5 g of 4-trifluoromethylnicotinamide, 0.25 g of tetrafluorobenzyl ester, 8.0 g of ethanol, 7.5 g of N,N-dimethylacetamide, and propane to a final volume of 50.0 g were added to prepare a metered-dose aerosol according to the above method.

[0026] Formulation Example 2: 3.6% 4-Trifluoromethylnicotinamide·Tetrafluorobenzenepyrethrin Metered-Count Aerosol 1.5 g of 4-trifluoromethylnicotinamide, 0.3 g of tetrafluorobenzyl benzoate, 15.0 g of dimethyl carbonate, 2.5 g of isopropanol, and dimethyl ether to make up to 50.0 g were added to prepare a metered-dose aerosol according to the above method.

[0027] Formulation Example 3: 10% 4-Trifluoromethylnicotinamide·Tetrafluorobenzenepyrethrin Metered-Count Aerosol 2.5 g of 4-trifluoromethylnicotinamide, 2.5 g of tetrafluorobenzyl ester, 20.0 g of propylene carbonate, 7.5 g of diisopropyl adipate, and 50.0 g of propane and butane were added to make up to 50.0 g, and a metered-dose aerosol was prepared according to the above method.

[0028] Formulation Example 4: 12% 4-Trifluoromethylnicotinamide·Tetrafluorobenzenepyrethrin Metered-Count Aerosol 1.0 g of 4-trifluoromethylnicotinamide, 5.0 g of tetrafluorobenzyl ester, 6.0 g of propylene glycol methyl ether, 18.0 g of n-propanol, and compressed air to make up to 50.0 g were used to prepare a metered-dose aerosol according to the above method.

[0029] Formulation Example 5: 22% 4-Trifluoromethylnicotinamide·Tetrafluorobenzenepyrethrin Metered-Count Aerosol 1.0 g of 4-trifluoromethylnicotinamide, 10.0 g of tetrafluorobenzyl pyrethrin, 5.0 g of diisopropyl adipate, 15.0 g of ethanol, and liquefied petroleum gas to make up to 50.0 g were added to prepare a metered-dose aerosol according to the above method.

[0030] Formulation Example 6: 5.5% 4-Trifluoromethylnicotinamide·methoxybenzylflumethinamide metered-dose aerosol 2.5 g of 4-trifluoromethylnicotinamide, 0.25 g of methoxybenzylfluorometholone, 10.0 g of dibutyl carbonate, 8.0 g of glycerol butyl ether, and 50.0 g of propane and butane were added to obtain a metered-dose aerosol according to the above method.

[0031] Formulation Example 7: 6% 4-Trifluoromethylnicotinamide·methoxybenzylflumethinamide metered-dose aerosol 2.5 g of 4-trifluoromethylnicotinamide, 0.5 g of methoxybenzylfluorometholone, 12.0 g of dimethyl adipic acid, 10.0 g of N,N-dimethylacetamide, and dimethyl ether to make up to 50.0 g were added to prepare a metered-dose aerosol according to the above method.

[0032] Formulation Example 8: 10% 4-Trifluoromethylnicotinamide·methoxybenzylflumethinamide metered-dose aerosol 2.5 g of 4-trifluoromethylnicotinamide, 2.5 g of methoxybenzylflumethinamide, 10.0 g of γ-butyrolactone, 6.0 g of sec-butanol, 5.0 g of ethanol, and 50.0 g of propane and butane were added to make up to 50.0 g, and a metered-dose aerosol was prepared by the above method.

[0033] Formulation Example 9: 18% 4-Trifluoromethylnicotinamide·methoxybenzylflumethinamide metered-dose aerosol 1.5 g of 4-trifluoromethylnicotinamide, 7.5 g of methoxybenzylflumethinamide, 10.0 g of tributyl acetyl citrate, 5.0 g of N,N-dimethyldecanoamide, and dimethyl ether to make up to 50.0 g were added to prepare a metered-dose aerosol according to the above method.

[0034] Formulation Example 10: 22% 4-Trifluoromethylnicotinamide·methoxybenzylflumethinamide metered-dose aerosol 1.0 g of 4-trifluoromethylnicotinamide, 10.0 g of methoxybenzylfluorometholone, 5.0 g of isopropyl myristate, 12.0 g of diisopropyl adipate, and compressed air to make up to 50.0 g were used to prepare a metered-dose aerosol according to the above method.

[0035] Formulation Example 11: 3.3% 4-Trifluoromethylnicotinamide·Tetrafluorobenzenepyrethrin Metered-Count Aerosol 1.5 g of 4-trifluoromethylnicotinamide, 0.15 g of tetrafluorobenzenepyrethrin, 5.0 g of N,N-dimethylacetamide, 15.0 g of diisopropyl adipate, and 50.0 g of propane and butane were added to make up to 50.0 g to prepare a metered-dose aerosol.

[0036] Formulation Example 12: 4.8% 4-Trifluoromethylnicotinamide·Tetrafluorobenzenepyrethrin Metered Aerosol 2.0 g of 4-trifluoromethylnicotinamide, 0.4 g of tetrafluorobenzenepyrethrin, 7.5 g of dipropylene glycol dimethyl ether, 7.5 g of dibutyl adipate, and dimethyl ether to make up to 50.0 g were used to prepare a metered-dose aerosol according to the above method.

[0037] Formulation Example 13: 6% 4-Trifluoromethylnicotinamide·Tetrafluorobenzenepyrethrin Quantitative Aerosol 1.5 g of 4-trifluoromethylnicotinamide, 1.5 g of tetrafluorobenzenepyrethrin, 7.5 g of isopropyl myristate, 10.0 g of propylene glycol phenyl ether, and liquefied petroleum gas to make up to 50.0 g were added to prepare a metered-dose aerosol according to the above method.

[0038] Formulation Example 14: 6% 4-Trifluoromethylnicotinamide·Tetrafluorobenzenepyrethrin Metered Aerosol 0.5 g of 4-trifluoromethylnicotinamide, 2.5 g of tetrafluorobenzenepyrethrin, 12.0 g of dibutyl adipate, 10.0 g of tributyl acetyl citrate, and propane to a final volume of 50.0 g were added to obtain a metered-dose aerosol.

[0039] Formulation Example 15: 5.5% 4-Trifluoromethylnicotinamide·Tetrafluorobenzenepyrethrin Metered Aerosol A metered-dose aerosol was prepared by adding 0.25 g of 4-trifluoromethylnicotinamide, 2.5 g of tetrafluorobenzenepyrethrin, 10.0 g of isopropyl myristate, 12.0 g of ethanol, and propane to a final volume of 50.0 g.

[0040] Application Example 1: Determination of the co-toxicity coefficient of 4-trifluoromethylnicotinamide and pyrethroids Experimental target: Culex pipiens pallens (a resistant mosquito species native to Yangzhou), female adult mosquitoes that did not feed on blood on the 3rd day after emergence; Test method: Refer to NY / T1154.7-2006 "Guidelines for Indoor Bioassay Tests of Pesticides - Insecticides - Part 7: Determination of Combined Effects of Mixtures"; Table 1. Determination of the co-toxicity coefficients of 4-trifluoromethylnicotinamide and tetrafluorobenzenepyrin

[0041] As shown in Table 1, when the ratio of 4-trifluoromethylnicotinamide to tetrafluorobenzylpyrene is 10:1 to 1:10, the co-toxicity coefficient against Culex pipiens pallens is greater than 120, showing a synergistic effect. The synergistic effect is most obvious when the ratio is 1:1.

[0042] Table 2. Determination of the co-toxicity coefficients of 4-trifluoromethylnicotinamide and methoxybenzylflupyrrolizamide

[0043] As shown in Table 2, when the ratio of 4-trifluoromethylnicotinamide to methoxybenzylflupyrrin is 15:1 to 1:10, the co-toxicity coefficient against Culex pipiens pallens is greater than 120, showing a synergistic effect. The synergistic effect is most obvious when the ratio is 1:1.

[0044] Table 3. Determination of co-toxicity coefficients of 4-trifluoromethylnicotinamide and tetrafluorobenzenepyrethrin

[0045] As shown in Table 3, when the ratio of 4-trifluoromethylnicotinamide to tetrafluorobenzenepyrethrin is 10:1 to 1:15, the co-toxicity coefficient against Culex pipiens pallens is greater than 120, showing a synergistic effect. The synergistic effect is most obvious when the ratio is 1:5.

[0046] Application Example 2: Indoor Efficacy Test for Controlling Culex pipiens pallens Experimental target: Culex pipiens pallens (a resistant mosquito species native to Yangzhou), female adult mosquitoes that did not feed on blood on the 3rd day after emergence; Test method: Refer to GB / T 13917.10-2009, simulate the field; at 28m 3 In a simulated chamber (3.16m long, 3.16m wide, and 2.8m high), 100 Culex pipiens pallens mosquitoes were placed. The operator stood in the center of the chamber, 2m above the ground, and sprayed a metered-dose aerosol once at one corner of the chamber, totaling 0.5ml. A standard aerosol spray was then applied and weighed. The number of Culex pipiens pallens mosquitoes knocked down was observed within one hour, and the half-kill time (KT) was calculated. 50 ) and 24-hour mortality rate (%); Control sample: Control Sample 1: 1% 4-trifluoromethylnicotinamide·tetrafluorobenzylpyrene ordinary aerosol (the ordinary aerosol is a low-content aerosol, the normal spray volume is more than 10 times that of the metered aerosol, and there is no metering valve, and the sprayed droplets are also larger; it contains 0.5% 4-trifluoromethylnicotinamide + 0.5% tetrafluorobenzylpyrene), the solvent is the same as that of Formulation Example 3; Control sample 2: 1% 4-trifluoromethylnicotinamide·methoxybenzylflumethinyl ordinary aerosol (0.5% 4-trifluoromethylnicotinamide + 0.5% methoxybenzylflumethinyl), the solvent is the same as that in formulation example 8; Control sample 3: 0.6% 4-trifluoromethylnicotinamide·tetrafluorobenzenepyrethrin common aerosol (0.1% 4-trifluoromethylnicotinamide + 0.5% tetrafluorobenzenepyrethrin), the solvent is the same as that in formulation example 14.

[0047] Table 4. Results of efficacy comparison tests for formulation examples 3, 8, and 14

[0048] As shown in Table 4, under the same dosage (active ingredient) conditions, the metered-dose aerosol of this invention exhibits superior knockdown time and mortality rate against Culex pipiens pallens compared to the control sample. Furthermore, the efficacy is comparable only when the dosage of the control sample is 1.38 to 1.52 times that of the metered-dose aerosol. The experimental results demonstrate that the metered-dose aerosol formulation of this invention has superior efficacy compared to conventional aerosols.

[0049] Application Example 3: Indoor Duration Test for Controlling Culex pipiens pallens Experimental target: Culex pipiens pallens (a resistant mosquito species native to Yangzhou), female adult mosquitoes that did not feed on blood on the 3rd day after emergence; Test method: Refer to GB / T 13917.10-2009, simulate the field; at 28m 3 In a simulated chamber (3.16m long, 3.16m wide, and 2.8m high), the sprayer stood in the center of the chamber, 2m above the ground, and sprayed a metered amount of aerosol once at one corner of the chamber, for a total spray volume of 0.5m. The aerosol was sprayed normally and weighed. After 30 minutes, the ventilation system was turned on, and 100 Culex pipiens pallens mosquitoes were introduced 2 hours later. The number of mosquitoes knocked down was observed within one hour, and the half-kill time (KT) was calculated. 50 ) and 24-hour mortality rate (%); Control sample: Control sample 1: 1% 4-trifluoromethylnicotinamide·tetrafluorobenzyl ester ordinary aerosol (0.5% 4-trifluoromethylnicotinamide + 0.5% tetrafluorobenzyl ester), the solvent is the same as that in formulation example 3; Control sample 2: 1% 4-trifluoromethylnicotinamide·methoxybenzylflumethinyl ordinary aerosol (0.5% 4-trifluoromethylnicotinamide + 0.5% methoxybenzylflumethinyl), the solvent is the same as that in formulation example 8; Control sample 3: 0.6% 4-trifluoromethylnicotinamide·tetrafluorobenzenepyrethrin common aerosol (0.1% 4-trifluoromethylnicotinamide + 0.5% tetrafluorobenzenepyrethrin), the solvent is the same as that in formulation example 14.

[0050] Table 5 Results of efficacy comparison trials for formulation examples 3, 8, and 14

[0051] Based on the efficacy results in Application Example 2, the dosages of control samples 1, 2, and 3 were increased for a duration-of-effect test. The ventilation system was turned on 30 minutes after application, and the efficacy was tested after 2 hours. The results showed that the duration-of-effect of formulations 3, 8, and 14 was superior to that of control samples 1, 2, and 3, respectively. This is because the droplets sprayed from the formulations of this invention are smaller, allowing them to quickly diffuse throughout the space. Furthermore, the small droplets easily adhere to walls and the ground. In contrast, conventional aerosols, due to their larger droplets, settle to the ground quickly, resulting in fewer droplet particles adhering to the walls, thus leading to a shorter duration of effect compared to the metered-dose aerosol of this invention.

[0052] The above examples are merely illustrative of the technical concept and features of the present invention and should not be construed as limiting the scope of protection of the present invention. All equivalent transformations or modifications made in accordance with the essence of the present invention should be included within the scope of protection of the present invention.

Claims

1. A metered-dose aerosol containing 4-trifluoromethylnicotinamide, characterized in that: By weight percentage, it contains 0.2% to 25% of the active ingredient, 4-trifluoromethylnicotinamide, with the remainder being excipients; the excipients are solvents and propellants.

2. The metered-dose aerosol containing 4-trifluoromethylnicotinamide according to claim 1, characterized in that: The active ingredients containing 4-trifluoromethylnicotinamide are active ingredient A and active ingredient B; wherein, active ingredient A is selected from 4-trifluoromethylnicotinamide; and active ingredient B is selected from any one of tetrafluorobenzyl, methoxybenzylflufenoxuron, and tetrafluorobenzylflufenoxuron.

3. The metered-dose aerosol containing 4-trifluoromethylnicotinamide according to claim 1 or 2, characterized in that: The metered aerosol contains, by weight percentage, 0.1-5% active ingredient A, 0.1-20% active ingredient B, 1-50% solvent, and the remainder is propellant.

4. The metered-dose aerosol containing 4-trifluoromethylnicotinamide according to claim 3, characterized in that: When the active ingredient B is selected from tetrafluorobenzyl pyrethrin, the mass ratio of active ingredient A to active ingredient B is 10:1 to 1:

10. When the active ingredient B is selected from methoxybenzylfluorometholone, the mass ratio of active ingredient A to active ingredient B is 15:1 to 1:

10. When the active ingredient B is selected from tetrafluorobenzenepyrethrin, the mass ratio of active ingredient A to active ingredient B is 10:1 to 1:

15.

5. The metered-dose aerosol containing 4-trifluoromethylnicotinamide according to claim 3, characterized in that: The solvent is one or more of the following: dimethyl carbonate, dibutyl carbonate, propylene carbonate, dimethyl adipate, diisopropyl adipate, dibutyl adipate, dimethyl succinate, dimethyl glutarate, γ-butyrolactone, isopropyl tridecaate, isopropyl tetradecaate, isopropyl hexadecanoate, tributyl acetyl citrate, propylene glycol methyl ether, propylene glycol phenyl ether, glycerol butyl ether, propylene glycol butyl ether, dipropylene glycol dimethyl ether, cyclohexanediol monomethyl ether, methyl tert-butyl ether, N,N-dimethyldecanoamide, N,N-dimethylacetamide, C8-18 alkane solvents, and C2-8 alcohol solvents.

6. The metered-dose aerosol containing 4-trifluoromethylnicotinamide according to claim 3, characterized in that: The propellant is one of liquefied petroleum gas, propane, dimethyl ether, or compressed air.

7. A method for preparing a metered-dose aerosol containing 4-trifluoromethylnicotinamide as described in claim 1, characterized in that: According to the above proportions, active ingredient A, active ingredient B and solvent are mixed at 30-50°C, and the mixture is added to a spray can equipped with a metering spray valve. Under pressure, propellant is added to the spray can to obtain a metered aerosol.

8. The application of the metered-dose aerosol containing 4-trifluoromethylnicotinamide as described in claim 1, characterized in that: Application of the metered aerosol in the field of controlling public health pests.

9. The application of the metered-dose aerosol containing 4-trifluoromethylnicotinamide according to claim 8, characterized in that: The sanitary pests mentioned are one or more of the following: mosquitoes, flies, bedbugs, and fleas.

10. The application of the metered-dose aerosol containing 4-trifluoromethylnicotinamide according to claim 8, characterized in that: The public places mentioned are one or more of the following: schools, residences, restaurant private rooms, hotels, and shopping malls.

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