一种异戊烯基化聚酮类化合物及其制备方法和应用
By isolating and purifying isopentenylated polyketides from rice fermentation products of *Carya niger*, the problem of insufficient understanding of their structure and neuroprotective mechanism has been solved, enabling their application in neuroprotective drugs, with significant neuroprotective activity and safety.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- HUNAN VOCATIONAL COLLEGE OF SCI & TECH
- Filing Date
- 2026-04-28
- Publication Date
- 2026-07-17
AI Technical Summary
The existing technology has limited systematic research on isopentenylated polyketides in *Carya niger*, and there is insufficient understanding of their structural types, structure-activity relationships and neuroprotective mechanisms, resulting in a lack of effective neuroprotective drugs for development.
Isoprene-based polyketide compounds were isolated and purified from rice fermentation products of *Caryopsis niger*. By combining rice fermentation with modern separation and purification techniques, compounds with isoprenyl side chains and polyketide backbones were prepared and showed neuroprotective activity in a glutamate-induced PC12 cell model.
Within the concentration range of 0.01–10 μM, the compound significantly improves cell viability, inhibits apoptosis, and alleviates oxidative stress, while exhibiting no significant toxicity to normal cells. This provides an important guarantee for neuroprotective drugs and demonstrates good safety and potential for industrial application.
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Figure CN122102876B_ABST