一种巴马汀衍生物、制备方法及其应用
By synthesizing 9,13-disubstituted palmatine derivatives, the problem of Helicobacter pylori drug resistance was solved, and effective inhibition of spiral and spherical variant strains was achieved, providing a novel anti-Helicobacter pylori drug with a novel mechanism of action.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
- Filing Date
- 2026-04-29
- Publication Date
- 2026-07-17
AI Technical Summary
The problem of drug resistance in existing antibiotic treatments for Helicobacter pylori is serious, leading to treatment failure and increased adverse drug reactions. There is an urgent need to develop new anti-Helicobacter pylori drugs with novel mechanisms of action, especially those that can effectively kill spheroids.
A palmatine derivative was synthesized by introducing specific substituents at the 9 and 13 positions of palmatine to form a 9,13-disubstituted isoquinoline derivative, which exhibits antibacterial activity against both spiral and spherical Helicobacter pylori, thus avoiding cross-resistance.
This palmatine derivative is effective against Helicobacter pylori strains resistant to clarithromycin and metronidazole, exhibiting superior activity compared to existing drugs. It can inhibit the growth of cocci, broaden the therapeutic spectrum, and meet clinical needs.
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Figure CN122103128B_ABST