Preparation method and application of tau-derived minimal functional peptide targeting cul3-rhoa axis

Abstract

The application discloses a preparation method and application of a Tau-derived minimum functional peptide targeting a CUL3-RhoA axis, and an amino acid sequence of the Tau-derived minimum functional peptide is shown as SEQ ID NO. 4: GNIHHKPGGGQVEVKSEKLD. The application of the Tau-derived minimum functional peptide targeting the CUL3-RhoA axis in the preparation of a drug for treating diseases related to over-activation of osteoclasts belongs to the technical field of biological medicines, and the drug plays a pharmacological effect by blocking RhoA ubiquitination through CUL3, activating a RhoA-ROCK-MLC2 tension axis, and destroying a closed loop of osteoclasts. The Tau-derived minimum functional peptide can avoid application defects of full-length proteins, has low toxicity, high selectivity and physiological friendliness.

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