Magnetic molecularly imprinted polymer and preparation method and application thereof

By preparing Fe3O4@SiO2@PAMAM magnetic molecularly imprinted polymers, the problem of low separation efficiency of Schisandra lignans in complex matrices was solved, achieving separation effects with high selectivity and high adsorption capacity, which is suitable for the fields of medicine and functional food.

CN122103477APending Publication Date: 2026-05-29SHAANXI UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHAANXI UNIV OF SCI & TECH
Filing Date
2026-02-28
Publication Date
2026-05-29

AI Technical Summary

Technical Problem

Existing technologies struggle to efficiently separate schisandrin lignans from complex matrices, exhibiting problems such as insufficient selectivity and low separation efficiency, leading to high extraction costs and limiting their application in the pharmaceutical and functional food fields.

Method used

Using Fe3O4 nanoparticles as the magnetic core, SiO2 was coated and PAMAM grafted onto them via the sol-gel method. Combined with a deep eutectic solvent and schisandrin lignan template molecules, Fe3O4@SiO2@PAMAM magnetic molecularly imprinted polymers were prepared for magnetic solid-phase extraction combined with HPLC to achieve separation with high selectivity and high adsorption capacity.

Benefits of technology

It achieves efficient adsorption and selective separation of schisandrin lignans with an adsorption rate close to 100%, high separation purity, and low detection limit, making it suitable for precise analysis of complex matrices, simplifying the operation process and reducing costs.

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Abstract

The application belongs to the technical field of functional materials, and discloses a magnetic molecular imprinting polymer as well as a preparation method and application thereof. Fe3O4 nanoparticles are taken as a magnetic inner core, SiO2 is coated on the Fe3O4 nanoparticles by a sol-gel method to obtain Fe3O4@SiO2, PAMAM is grafted, a deep eutectic solvent and a schisandrin lignan template molecule are combined, pre-polymerization and polymerization are performed to obtain Fe3O4@SiO2@PAMAM magnetic molecular imprinting polymers (MMIPs). The MMIPs have high adsorption capacity and selectivity for schisandrin lignans, are used as a magnetic solid phase extraction (MSPE) adsorbent, are combined with HPLC, have excellent linear relationship (R 2 ≥0.9993), have low detection limit, can efficiently separate and enrich lignans in schisandra, and provide a new method for extraction of natural active ingredients.
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