一种基于HAPLN1下调诱导胎盘细胞衰老异常的子痫前期动物模型构建方法及应用
By injecting pregnant mice with Ad-shHAPLN1 virus to downregulate HAPLN1 expression, an animal model of preeclampsia was constructed, which solved the problem that existing models could not reflect placental cell aging and achieved a comprehensive simulation and reproduction of the pathological features of preeclampsia.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- THE WEST CHINA SECOND UNIV HOSPITAL OF SICHUAN
- Filing Date
- 2026-04-13
- Publication Date
- 2026-07-17
AI Technical Summary
Existing animal models of preeclampsia are unable to effectively reflect the core pathological process of placental cell aging and cannot fully simulate the systemic multi-system dysfunction of the disease.
By injecting pregnant mice with Ad-shHAPLN1 virus to downregulate HAPLN1 expression, an animal model of preeclampsia that can reproduce abnormal placental cell aging was constructed, and related pathological indicators such as blood pressure, urinary protein, organ pathological changes, and intrauterine development of offspring were monitored.
It successfully simulated the main clinical manifestations of preeclampsia, including persistent high blood pressure, multiple organ damage, and fetal growth restriction, and dynamically reflected abnormal placental cell aging, thus having stronger pathological representativeness and practicality.
Smart Images
Figure CN122104811B_ABST