A Lizun-Bone Marrow Intraosseous Targeted Drug Delivery System
By implanting a spherical drug-containing structure into the bone marrow cavity through minimally invasive intervention, the drug can be sustained and evenly dispersed within the bone marrow cavity. This overcomes the shortcomings of systemic drug delivery methods, achieves local targeted therapy for leukemia, reduces side effects, and is suitable for both adults and children.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- 马文杰
- Filing Date
- 2026-03-04
- Publication Date
- 2026-06-02
AI Technical Summary
Traditional systemic drug delivery methods for treating leukemia result in low drug concentrations within the bone marrow cavity, making it difficult to achieve stable and effective therapeutic concentrations. Furthermore, they can damage normal tissues and organs. There is a lack of structures that can be directly implanted into the bone marrow cavity to achieve local drug release.
A spherical drug-containing structure made of biodegradable polymer material is designed and implanted into the bone marrow cavity via minimally invasive intervention. The drug is then released and uniformly diffused within the bone marrow cavity to achieve local targeted therapy.
It achieves local treatment of diseased cells in the bone marrow cavity, reduces systemic side effects, improves treatment efficacy, is suitable for adults and children, and is simple to operate and highly safe.
Smart Images
Figure CN122123987A_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of medical device technology, and in particular to a Lizun-Bone Marrow Targeted Drug Delivery System. Background Technology
[0002] Leukemia originates from the abnormal proliferation of hematopoietic cells within the bone marrow cavity. Traditional treatments often involve systemic drug administration, which results in low systemic drug concentrations, significant side effects, and difficulty in achieving stable and effective therapeutic concentrations within the bone marrow cavity. Furthermore, it can easily damage normal tissues and organs. Currently, there is a lack of structures that can be directly implanted into the bone marrow cavity to achieve local drug release, thus limiting clinical treatment options. Summary of the Invention
[0003] Purpose of the invention: The purpose of this invention is to overcome the shortcomings of the prior art and provide a method that can be implanted into the bone marrow cavity of the human or animal body through interventional means, and release drugs within the bone marrow cavity to achieve local targeted therapy of diseased cells in the bone marrow cavity, reduce systemic side effects, and improve treatment efficacy.
[0004] A drug-containing structure for targeted therapy of the bone marrow cavity, wherein the drug-containing structure can be implanted into the bone marrow cavity of a human or animal via intervention; the drug-containing structure can release drugs within the bone marrow cavity.
[0005] Beneficial effects: 1. Direct implantation into the medullary cavity to achieve local drug delivery to the lesion; 2. The drug diffuses within the bone marrow cavity, maintaining a stable therapeutic concentration; 3. It does not rely on systemic administration, significantly reducing systemic side effects; 4. Applicable to intraosseous targeted therapy for leukemia in adults and children; 5. Interventional implantation is minimally invasive, easy to perform, and highly safe. Attached Figure Description
[0006] Figure 1 This is a schematic diagram of the drug-containing structure of the present invention. Detailed Implementation
[0007] To make the technical solution of the present invention clearer, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.
[0008] This embodiment discloses a Lizun-Bone Marrow Targeted Drug Delivery System (L-TDS).
[0009] The drug-containing structure of this system is spherical with an overall size of 1 mm to 2 mm. It is made of biodegradable polymer material. The drug-containing structure loads therapeutic drugs, which are distributed in a sustained-release manner inside and on the surface of the drug-containing structure. The implantation method is minimally invasive interventional implantation: under image guidance, a bone marrow cavity channel is established through a puncture needle, and the drug-containing structure is delivered into the designated location in the bone marrow cavity through the puncture channel to complete the implantation. After implantation, the drug-containing structure continuously releases drugs in the internal environment of the bone marrow cavity. The drugs are evenly diffused in the bone marrow fluid and have a sustained inhibitory effect on abnormally proliferating cells in the bone marrow cavity.
[0010] The system described in this embodiment is suitable for intramedullary targeted therapy of leukemia in adults and children.
[0011] The embodiments described above are merely illustrative of several implementations of the present invention, and while the descriptions are specific and detailed, they should not be construed as limiting the scope of the present invention. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these modifications and improvements all fall within the scope of protection of the present invention. Therefore, the scope of protection of this patent should be determined by the appended claims.
Claims
1. A drug-containing structure for intraosseous cavity targeted therapy, characterized in that, This drug-containing structure can be implanted into the bone marrow cavity of humans and animals via intervention; the drug-containing structure can release drugs within the bone marrow cavity.