An array nanopore acoustoelectric coupling driving protein positioning electrolytic machining method, an array nanopore prepared by the method and an application thereof

CN122125302APending Publication Date: 2026-06-02NANJING UNIV OF AERONAUTICS & ASTRONAUTICS

Patent Information

Authority / Receiving Office: CN · China
Patent Type: Applications(China)
Current Assignee / Owner: NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
Filing Date: 2026-01-13
Publication Date: 2026-06-02

AI Technical Summary

Technical Problem

Existing electrochemical machining techniques are difficult to achieve sub-nanometer scale array nanopore processing in metallic materials, and traditional acoustic tweezers techniques suffer from weakened acoustic radiation force, hydrodynamic interference, and thermal noise at the near-atomic scale, resulting in unstable processing and difficulty in signal extraction.

Method used

By using the micro-elastic deformation generated by a single-crystal piezoelectric sheet to form a planar standing wave field, combined with the acoustic-electric coupling effect, and using a displacement sensor to precisely control the positioning and electrolytic processing of ion channel proteins, efficient fabrication of array nanopores is achieved.

Benefits of technology

This method efficiently fabricates arrays of nanopores with diameters approaching 1 nm on metal surfaces, overcoming the limitations of traditional methods in terms of material type and scale, improving fabrication accuracy and stability, and making it suitable for single-molecule sensors, nanofiltration membranes, and quantum dot array devices.

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Abstract

A method for electrochemically fabricating arrayed nanopores driven by acoustic-electric coupling, along with the resulting arrayed nanopores and their applications, relates to the field of micro / nano electrochemical fabrication. The method first forms a phospholipid bilayer mask intercalated with ion channel proteins on the surface of a metal anode. By applying electrical signals of specific frequency and phase to multiple pairs of displacement sensors placed around a single-crystal piezoelectric element, the piezoelectric element undergoes elastic deformation, forming a planar standing wave field in the electrolyte. Utilizing the dielectrophoretic force generated by the acoustic-electric coupling effect, the ion channel proteins are precisely captured and anchored at the standing wave nodes, forming a controllable protein array. Finally, a voltage is applied between the anode and the tool cathode to initiate an anodic dissolution reaction within the protein-confined nanochannels, fabricating arrayed nanopores corresponding to the protein array on the metal surface. This invention effectively suppresses fluid disturbances and thermal noise, achieving high-precision, designable fabrication of sub-nanometer aperture, highly ordered arrayed nanopores on metal surfaces.

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