An acne composition, use and skin care product

Abstract

The application belongs to the technical field of skin care, and discloses a kind of acne-removing composition, use and skin care product, the acne-removing composition includes kuding tea extract and olea leaf extract, and the weight ratio of the kuding tea extract and the olea leaf extract is 1-4:1-2.The application provides an acne-removing composition, which produces a synergistic effect of improving bacteriostatic effect by combining kuding tea extract and olea leaf extract, thereby improving the skin acne-removing efficacy.

Description

Technical Field

[0001] This application relates to the field of skin care technology, specifically to an acne-removing composition, its uses, and skin care products. Background Technology

[0002] The formation of acne is closely related to the excessive proliferation of pathogenic bacteria such as Propionibacterium acnes. These bacteria decompose sebum to produce free fatty acids, triggering inflammatory reactions in hair follicles. Therefore, antibacterial treatment has become one of the core methods for acne removal.

[0003] Existing antibacterial compositions primarily improve acne by regulating the skin's microecological balance. For example, prior art 1: US07314659 discloses a benzoyl peroxide and quaternary ammonium-based pharmaceutical and cosmetic composition for topical application, comprising benzoyl peroxide and a combination of quaternary ammonium salts selected from alkyl sulfates, aryl sulfonates, and alkyl aryl sulfonates in a physiologically acceptable medium. The specification of prior art 1 states: "Benzyl peroxide is a known therapeutic agent for treating acne, and has been known for several years as a particularly interesting keratolytic agent. Among other qualities, it also possesses good antibacterial properties."

[0004] Existing technology 1 uses cosmetic compositions containing benzoyl peroxide to inhibit bacteria and treat acne. However, due to technological advancements and changes in people's lifestyles, benzoyl peroxide, despite its significant efficacy in dermatological applications, has a relatively obvious disadvantage: benzoyl peroxide has a relatively obvious skin irritant effect, causing users to experience dryness, peeling, erythema, or burning sensations, especially during initial use. Its oxidation can damage the skin barrier, potentially inducing contact dermatitis in people with sensitive skin.

[0005] Generally, the active ingredients in natural plants have high safety and low skin irritation; therefore, based on the need for skin gentleness, it is necessary to find natural active ingredients for antibacterial purposes. Summary of the Invention

[0006] One of the objectives of this application is to provide an acne-removing composition, which is formed by combining bitter tea extract and olive leaf extract. It is formed by combining natural plant active ingredients, has low irritation, and can exert excellent antibacterial and acne-removing effects.

[0007] Another objective of this application is to provide the application of acne-removing compositions in the preparation of skin care products.

[0008] In addition, this application also provides a skin care product containing the acne-removing composition of this application, which has excellent antibacterial and acne-removing effects and the advantage of low irritation.

[0009] To achieve the above objectives, this application provides an acne-removing composition comprising bitter tea extract and olive leaf extract, wherein the weight ratio of bitter tea extract to olive leaf extract is 1-4:1-2.

[0010] Preferably, the weight ratio of bitter tea extract to olive leaf extract is 4:1.

[0011] This application also provides the use of the above-described acne-removing composition in the preparation of skin care products.

[0012] This application also discloses a skin care product containing 0.25-2wt% of the above-mentioned acne-removing composition.

[0013] Beneficial effects

[0014] Compared with the prior art, this application provides an acne-removing composition that, through the combination of bitter tea extract and olive leaf extract, produces a synergistic effect to enhance the antibacterial effect, thereby improving the skin's acne-removing efficacy. Detailed Implementation

[0015] The present application will be further described below with reference to embodiments, but this does not constitute any limitation on the present application. Any limited modifications made within the scope of the claims of the present application shall still be within the scope of the claims of the present application.

[0016] To illustrate the technical content of this application in detail, the following description is provided in conjunction with the embodiments.

[0017] In the following embodiments and comparative examples, unless otherwise specified, the parts are parts by weight and the percentage is a weight percentage.

[0018] Example 1

[0019] An acne-removing composition comprising 4 parts bitter tea extract and 1 part olive leaf extract.

[0020] Example 2

[0021] An acne-removing composition comprising 3 parts bitter tea extract and 1 part olive leaf extract.

[0022] Example 3

[0023] An acne-removing composition comprising 2 parts bitter tea extract and 1 part olive leaf extract.

[0024] Example 4

[0025] An acne-removing composition comprising 1 part bitter tea extract and 1 part olive leaf extract.

[0026] Example 5

[0027] An acne-removing composition comprising 1 part bitter tea extract and 2 parts olive leaf extract.

[0028] Comparative Example 1

[0029] An acne-removing composition comprising 1 part bitter tea extract and 3 parts olive leaf extract.

[0030] Comparative Example 2

[0031] An acne-removing composition comprising 1 part bitter tea extract and 4 parts olive leaf extract.

[0032] Comparative Example 3

[0033] An acne-removing composition comprising 5 parts bitter tea extract and 1 part olive leaf extract.

[0034] Comparative Example 4

[0035] 1 part bitter tea extract.

[0036] Comparative Example 5

[0037] 1 part olive leaf extract.

[0038] The sample was prepared according to the formula in Table 1 for testing. The preparation method was to stir and mix the sample at room temperature.

[0039] Table 1 Sample Formulation Table

[0040] Active Composition water Sample 1 1.1% Comparative Example 4 To 100% Sample 2 0.275% vs. Example 5 To 100% Sample 3 1.375% Example 1 To 100% Sample 4 1.375% Comparative Example 4 To 100% Sample 5 1.375% vs. Example 5 To 100% Sample 6 1.375% Example 2 To 100% Sample 7 1.375% Example 3 To 100% Sample 8 1.375% Example 4 To 100% Sample 9 1.375% Example 5 To 100% Sample 10 1.375% Comparative Example 1 To 100% Sample 11 1.375% Comparative Example 2 To 100% Sample 12 1.375% Comparative Example 3 To 100%

[0041] Antibacterial effect test of Propionibacterium acnes

[0042] 1. Experimental Objective and Principle

[0043] Propionibacterium acnes is a Gram-positive anaerobic bacterium widely distributed in the lipids of human skin, primarily in hair follicles and sweat glands, and is a normal symbiotic flora of the skin. Numerous studies have shown that Propionibacterium acnes is closely related to excessive sebum secretion, hyperkeratosis, inflammation, and tissue damage.

[0044] Propionibacterium acnes can promote sebum secretion and produce various enzymes such as protease, lipase, hyaluronidase, and ceramide glycoside endopeptidase, which damage the integrity of epidermal cells, leading to excessive keratinization of the follicular infundibulum, causing sebaceous duct obstruction, and forming acne. In addition, Propionibacterium acnes can also convert triglycerides in sebum into free fatty acids, which can worsen acne.

[0045] 2 Test Indicators

[0046] Criteria for determining the antibacterial rate of Propionibacterium acnes: An antibacterial rate ≥50% indicates that the sample has a certain acne-removing effect. The higher the antibacterial rate of Propionibacterium acnes, the stronger the acne-removing effect of the sample.

[0047] 3. Experimental Materials and Methods

[0048] 3.1 Instruments and Equipment

[0049] Anaerobic incubator

[0050] Vertical high-pressure steam sterilizer

[0051] 3.2 Reagents

[0052] Phosphate buffer

[0053] Fortified Clostridium tumefaciens medium (RCM)

[0054] Propionibacterium acnes

[0055] 3.3 Test Methods

[0056] (1) Treatment of control materials and test samples

[0057] Sample: Original sample solution;

[0058] Control sample group: Propionibacterium acnes suspension + phosphate buffer.

[0059] (2) Experimental operation procedures

[0060] Take a suspension of Propionibacterium acnes and add it to each sample solution and control solution, mix well, and start timing. After the specified reaction time, dilute appropriately. Take 2-3 dilutions and place the sample solution and control solution into two petri dishes respectively. Pour in Clostridium repens (RCM) medium and mix well. After solidification, invert the plates and incubate in an anaerobic incubator for 48 hours, then count the viable bacteria.

[0061] (3) Calculation formula

[0062] The inhibition rate of Propionibacterium acnes = (A - B) / A * 100%;

[0063] A—Average colony count of control samples; B—Average colony count of test samples.

[0064] Samples 1-12 were tested according to the above test method, and the results are shown in Table 2.

[0065] Table 2. Results of antibacterial activity test of Propionibacterium acnes in samples 1-12

[0066] Antibacterial rate of Propionibacterium acnes Sample 1 26.67% Sample 2 43.33% Sample 3 60.00% Sample 4 37.50% Sample 5 38.75% Sample 6 43.75% Sample 7 47.50% Sample 8 43.75% Sample 9 45.63% Sample 10 31.25% Sample 11 38.75% Sample 12 45.00%

[0067] According to the results in Table 2:

[0068] Based on the data comparison between samples 1 and 4, and between samples 2 and 5, it can be seen that increasing the concentration of bitter tea extract will increase the antibacterial rate of Propionibacterium acnes, but the effect is relatively limited and does not reach the antibacterial effect of the test standard; while increasing the concentration of olive leaf extract will lead to a decrease in its antibacterial rate of Propionibacterium acnes, and it is not suitable for use alone.

[0069] Furthermore, based on the data comparison between samples 6-12 and samples 1, 2, 5, and 4, it can be seen that when Kuding tea extract and olive leaf extract are combined, at the same concentration of 1.375%, the antibacterial effect of the combination is effectively improved compared to using Kuding tea extract or olive leaf extract alone, indicating that the combination of Kuding tea extract and olive leaf extract has a certain synergistic effect.

[0070] However, according to the results of samples 6-12, although the combination of bitter tea extract and olive leaf extract has a certain synergistic effect in enhancing the antibacterial effect of the composition, it still does not reach the antibacterial effect of the test standard, and it does not effectively inhibit bacteria. However, according to the data of sample 3, when the ratio of bitter tea extract and olive leaf extract is limited to 4:1, the antibacterial rate of Propionibacterium acnes is significantly improved, and the composition shows an effective antibacterial effect at a concentration of 1.375%.

[0071] Samples of different concentrations were prepared according to the formulation table in Table 3.

[0072] Table 3 Formulation table for Example 1 at different concentrations

[0073] Active Composition water Sample 3 1.375% Example 1 To 100% Sample 13 0.125% Example 1 To 100% Sample 14 0.250% Example 1 To 100% Sample 15 0.500% Example 1 To 100% Sample 16 1.000% Example 1 To 100% Sample 17 1.500% Example 1 To 100% Sample 18 2.000% Example 1 To 100% Sample 19 2.500% Example 1 To 100%

[0074] Samples 1-12 were tested according to the above test method, and the results are shown in Table 4.

[0075] Table 4. Results of the antibacterial ability test of Propionibacterium acnes in Samples 3 and 13-19

[0076] Antibacterial rate of Propionibacterium acnes Sample 3 60.00% Sample 13 0.00% Sample 14 7.69% Sample 15 7.69% Sample 16 15.38% Sample 17 23.08% Sample 18 26.92% Sample 19 28.46%

[0077] According to the results in Table 4:

[0078] With a fixed ratio of bitter tea extract and olive leaf extract of 4:1, the composition exhibited effective antibacterial activity only at a concentration of 1.375%.

[0079] The embodiments presented herein are merely selected implementations based on combinations of all possible embodiments. The appended claims should not be limited to the embodiments described herein. Some numerical ranges used in the claims include sub-ranges within them, and variations within these ranges should also be covered by the appended claims.

Claims

1. An acne-removing composition, characterized in that, It includes bitter tea extract and olive leaf extract, wherein the weight ratio of bitter tea extract to olive leaf extract is 1-4:1-2.

2. The acne-removing composition according to claim 1, characterized in that, The weight ratio of bitter tea extract to olive leaf extract is 4:

1.

3. Use of the acne-removing composition as described in claim 1 or 2 to prepare skin care products.

4. A skincare product, characterized in that, Contains 0.25-2 wt% of the acne-removing composition as described in claim 1 or 2.