Ginger and mint complex patch

Abstract

The ginger and mint composite patch is composed of, in sequence, an anti-sticking layer, a ginger storage layer, a mint storage layer and a backing layer; the mint storage layer is composed of menthol and a pressure-sensitive adhesive matrix, and the weight percentage content of menthol in the ginger storage layer is 0.1%-1%; the ginger storage layer is composed of ginger extract, stearic acid and a pressure-sensitive adhesive matrix, the weight ratio of ginger extract and stearic acid is 1:0.5-1, the weight percentage content of ginger extract in the ginger storage layer is 1-5%, and the weight ratio of menthol and ginger extract is 1:1-3.

Description

Technical Field

[0001] This invention relates to a transdermal drug delivery formulation, and more particularly to a patch. Background Technology

[0002] Peppermint (scientific name: *Mentha canadensis* L.) is a perennial herb belonging to the genus *Mentha* in the family Lamiaceae. The whole plant or leaves can be used as a traditional Chinese medicine, possessing properties that dispel wind-heat, clear the head and eyes, soothe the throat and promote rash eruption, and soothe the liver and regulate qi. Peppermint essential oil is a natural extract obtained by water distillation or subcritical low-temperature extraction. The main active ingredient in peppermint essential oil is menthol, a terpene organic compound. Externally, it is used for local analgesia, antipruritic effects, headaches, dizziness, and insect bites. It can also be used as an active ingredient in soothing cold compresses. Patches containing peppermint can cool the body, constrict blood vessels, and reduce internal bleeding and swelling. However, for minor sprains and contusions, as time progresses, further anti-inflammatory, analgesic, and blood circulation-promoting treatments are needed, and menthol alone is insufficient to meet these requirements.

[0003] Preliminary studies have shown that ginger is warm in nature and possesses properties such as inducing sweating to relieve exterior syndromes, warming the middle jiao to stop vomiting, warming the lungs to stop coughing, and detoxification. When applied externally, it can promote blood circulation, remove blood stasis, warm the middle jiao to dispel cold, and dispel cold to relieve exterior syndromes. However, ginger is a warming herb and is not suitable for initial application to injured areas. Therefore, providing a composite skin patch that can exert a sustained effect and leverage the respective properties of ginger and mint is a pressing issue that needs to be addressed in current technology. Summary of the Invention

[0004] To solve the aforementioned technical problems, the technical solution adopted by the present invention is as follows:

[0005] A ginger-menthol composite patch is provided, the composite patch being composed of an anti-adhesive layer, a ginger storage layer, a menthol storage layer, and a backing layer in sequence.

[0006] The peppermint storage layer is composed of menthol and pressure-sensitive adhesive matrix, and the weight percentage of menthol in the ginger storage layer is 0.1%~1%.

[0007] The ginger storage layer is composed of ginger extract, stearic acid and pressure-sensitive adhesive matrix. The weight ratio of ginger extract to stearic acid is 1:0.5~1. The weight percentage content of ginger extract in the ginger storage layer is 1~5%. The weight ratio of menthol to ginger extract is 1:1~3, preferably 1:1.5~2.5.

[0008] The menthol composite patch further comprises a menthol content of 0.2% to 0.5% by weight in the menthol storage layer.

[0009] Furthermore, in the menthol composite patch, the ginger extract content in the ginger storage layer is 2% to 3% by weight, and the weight ratio of ginger extract to stearic acid is preferably 1:0.6 to 0.8.

[0010] Furthermore, in the menthol composite patch, the pressure-sensitive adhesive matrix is ​​a polyisobutylene pressure-sensitive adhesive matrix.

[0011] The menthol composite patch, further, is prepared using a method comprising the following steps:

[0012] 1) Mix menthol and polyisobutylene pressure-sensitive adhesive matrix evenly, coat it on the non-stick layer to form a menthol storage layer, and dry it at 65-85℃;

[0013] 2) Stearic acid is heated to 75-80℃ and then mixed evenly with ginger extract and polyisobutylene pressure-sensitive adhesive matrix. It is then coated on the surface of the peppermint storage layer to form a ginger storage layer. After drying at 65-85℃, it is laminated with the backing layer and cut into patches.

[0014] The ginger and mint composite patch provided by this invention adopts a double-layer drug storage structure. When the drug is administered, the mint drug storage layer first exerts a cooling and temperature-reducing effect to prevent further exudation at the damaged site. The ginger extract in the ginger drug storage layer, under the influence of body temperature, begins to exert its blood-activating and stasis-removing effect after about 2 hours of application, which can improve blood circulation, eliminate inflammation, and further promote the healing of the disease. Detailed Implementation

[0015] All percentages in all examples are by weight, and the weight ratio of menthol to ginger extract is fixed at 1:2.

[0016] Example 1

[0017] The peppermint storage layer contains 0.1% menthol and the remainder is a polyisobutylene pressure-sensitive adhesive matrix;

[0018] The ginger storage layer contains 1% ginger extract, 0.5% stearic acid, and the remainder is a polyisobutylene pressure-sensitive adhesive matrix.

[0019] The preparation method is as follows:

[0020] 1) Mix menthol and polyisobutylene pressure-sensitive adhesive matrix evenly, coat it on the non-stick layer to form a menthol storage layer, and dry it at 65-85℃;

[0021] 2) Stearic acid is heated to 75-80℃ and mixed evenly with ginger extract, then mixed with polyisobutylene pressure-sensitive adhesive matrix, and coated on the surface of the menthol storage layer to form a ginger storage layer. It is then dried at 65-85℃ and laminated with the backing layer, and cut into patches to form ginger menthol composite patches.

[0022] Example 2

[0023] The peppermint storage layer contains 0.2% menthol and the remainder is a polyisobutylene pressure-sensitive adhesive matrix;

[0024] The ginger storage layer contains 2% ginger extract, 1.2% stearic acid, and the remainder is a polyisobutylene pressure-sensitive adhesive matrix.

[0025] The preparation method is as follows:

[0026] 1) Mix menthol and polyisobutylene pressure-sensitive adhesive matrix evenly, coat it on the non-stick layer to form a menthol storage layer, and dry it at 65-85℃;

[0027] 2) Stearic acid is heated to 75-80℃ and mixed evenly with ginger extract, then mixed with polyisobutylene pressure-sensitive adhesive matrix, and coated on the surface of the menthol storage layer to form a ginger storage layer. It is then dried at 65-85℃ and laminated with the backing layer, and cut into patches to form ginger menthol composite patches.

[0028] Example 3

[0029] The peppermint storage layer contains 0.5% menthol and the remainder is a polyisobutylene pressure-sensitive adhesive matrix;

[0030] The ginger storage layer contains 3% ginger extract, 2.4% stearic acid, and the remainder is a polyisobutylene pressure-sensitive adhesive matrix.

[0031] The preparation method is as follows:

[0032] 1) Mix menthol and polyisobutylene pressure-sensitive adhesive matrix evenly, coat it on the non-stick layer to form a menthol storage layer, and dry it at 65-85℃;

[0033] 2) Stearic acid is heated to 75-80℃ and mixed evenly with ginger extract, then mixed with polyisobutylene pressure-sensitive adhesive matrix, and coated on the surface of the menthol storage layer to form a ginger storage layer. It is then dried at 65-85℃ and laminated with the backing layer, and cut into patches to form ginger menthol composite patches.

[0034] Example 4

[0035] The peppermint storage layer contains 1% menthol and the remainder is a polyisobutylene pressure-sensitive adhesive matrix.

[0036] The ginger storage layer contains 5% ginger extract, 5% stearic acid, and the remainder is a polyisobutylene pressure-sensitive adhesive matrix.

[0037] The preparation method is as follows:

[0038] 1) Mix menthol and polyisobutylene pressure-sensitive adhesive matrix evenly, coat it on the non-stick layer to form a menthol storage layer, and dry it at 65-85℃;

[0039] 2) Stearic acid is heated to 75-80℃ and mixed evenly with ginger extract, then mixed with polyisobutylene pressure-sensitive adhesive matrix, and coated on the surface of peppermint storage layer to form ginger storage layer. It is then dried at 65-85℃ and laminated with backing layer, and cut into patches to form ginger-peppermint composite patch.

[0040] The patch formulations in Examples 1-5 were examined and found to have uniformity of content, release rate, initial tack, holding power, and peel strength, all of which meet the relevant requirements for patches in Appendix IV of the 2015 edition of the Chinese Pharmacopoeia.

Claims

1. A ginger and mint compound patch, characterized in that... The composite patch consists of an anti-adhesive layer, a ginger medicine storage layer, a peppermint medicine storage layer, and a backing layer in sequence. The peppermint storage layer is composed of menthol and a pressure-sensitive adhesive matrix, with menthol accounting for 0.1% to 1% by weight in the ginger storage layer. The ginger storage layer is composed of ginger extract, stearic acid and pressure-sensitive adhesive matrix. The weight ratio of ginger extract to stearic acid is 1:0.5~1, the weight percentage content of ginger extract in the ginger storage layer is 1~5%, and the weight ratio of menthol to ginger extract is 1:1~3.

2. The ginger and mint composite patch as described in claim 1, characterized in that... The weight ratio of menthol to ginger extract is 1:1.5~2.

5.

3. The peppermint composite patch as described in claim 1 or 2, wherein the menthol content in the peppermint storage layer is 0.2% to 0.5% by weight.

4. The peppermint composite patch as described in claim 3, wherein the ginger extract content in the ginger storage layer is 2% to 3% by weight, and the weight ratio of ginger extract to stearic acid is 1:0.6 to 0.

8.

5. The peppermint composite patch as described in claim 4, characterized in that, The pressure-sensitive adhesive matrix is ​​a polyisobutylene pressure-sensitive adhesive matrix.

6. The peppermint composite patch as described in claim 5, characterized in that, The preparation method used includes the following steps: 1) Mix menthol and polyisobutylene pressure-sensitive adhesive matrix evenly, coat it on the non-stick layer to form a menthol storage layer, and dry it at 65-85℃; 2) Stearic acid is heated to 75-80℃ and then mixed evenly with ginger extract and polyisobutylene pressure-sensitive adhesive matrix. It is then coated on the surface of the peppermint storage layer to form a ginger storage layer. After drying at 65-85℃, it is laminated with the backing layer and cut into patches.