A pharmaceutical composition comprising meloxicam and a preparation method thereof

By using a combination of carboxymethyl cellulose and stabilizers in meregabalin formulations, the effects of light and high temperature on drug stability were addressed, resulting in faster disintegration and lower impurity content, thereby improving drug stability and absorption.

CN122140687APending Publication Date: 2026-06-05CHENGDU KANGHONG PHARMACEUTICAL GROUP CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-03
Publication Date
2026-06-05

AI Technical Summary

Technical Problem

Existing melogabalin formulations are susceptible to light and high temperatures during storage and transportation, leading to increased impurities, affecting drug stability and efficacy, and also resulting in a slow disintegration rate.

Method used

Carboxymethyl cellulose was used as a filler, and combined with stabilizers such as tartaric acid, anhydrous citric acid, pentiformic acid and butylated hydroxyanisole, the formulation of the drug composition was optimized, and the stabilizer ratio was controlled at 15:1, and it was prepared into oral dosage forms such as capsules, sprinkles, lozenges, sachets or tablets.

Benefits of technology

It improves the light stability of the drug, reduces the formation of impurities at high temperatures, and accelerates the drug disintegration rate, thus promoting drug absorption.

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Abstract

The application provides a pharmaceutical composition of meloxicam, comprising meloxicam, a pharmaceutically acceptable salt of meloxicam and a stabilizer, and has the advantages of good stability, fast disintegration and better suitability for mass production.
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Citation Information

Patent Citations

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