A heat-clearing and cough-relieving granule and a preparation method thereof

Abstract

The application relates to the technical field of medicine preparation, and discloses a heat-clearing and cough-relieving granule medicine and a preparation method thereof; the granule medicine is added with pericarpium citri reticulatae powder and microcrystalline cellulose, the pericarpium citri reticulatae powder and the microcrystalline cellulose generate a composite carrier skeleton, the skeleton is insoluble in gastric juice, can slowly release effective components, prolongs the drug effect time, meanwhile, the microcrystalline cellulose is micronized and is subjected to surface modification by means of bottom spraying and light coating of a fluidized bed, the pericarpium citri reticulatae powder is independently vacuum temperature-controlled and dried, a three-dimensional motion mixer and atomized water auxiliary mixing are matched to improve the uniformity of materials, a three-stage dynamic gradient negative pressure extraction, a linkage waste heat temperature control of a spraying pipeline and a heating system and low-frequency pulse ultrasonic collaborative extraction extraction process are combined, in-situ crosslinking is realized under the conditions of precise micro-negative pressure and constant temperature after extraction is completed, the skeleton structure integrity is ensured by means of a slow cooling rate, and finally, the effective components are slowly and continuously dissolved in gastric juice, and the drug effect duration is significantly prolonged.

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