An eye massage medium, a preparation method and application thereof

Abstract

The application provides an eye massage medium and a preparation method and application thereof, and belongs to the technical field of massage media, and comprises the following steps: under nitrogen protection, herbal mixed raw materials are subjected to ultrafine pulverization to obtain mixed ultrafine powder; the herbal mixed raw materials are composed of the following raw materials in parts by weight: 2-4 parts of peppermint, 7-11 parts of borneol, 7-11 parts of honeyed monkshood flower, 7-11 parts of privet fruit, 18-22 parts of cassia seed, 4-6 parts of chrysanthemum, and 4-6 parts of Chinese olive; ethanol is added to the mixed ultrafine powder, ultrasonic-assisted extraction is carried out at 35-40 DEG C to obtain an extraction liquid; the extraction liquid is filtered to remove impurities to obtain a filtrate; the filtrate is concentrated under reduced pressure to obtain a compound extract powder; the compound extract powder, selenium peptide and medical vaseline are uniformly stirred to obtain a pasty eye massage medium. The application can effectively improve the problems of pediatric visual fatigue and dry eyes, solves the defects of low effective component utilization rate and poor adaptability of the existing eye massage medium, and is safe and efficient in clinical application.

Description

Technical Field

[0001] This invention belongs to the field of massage medium technology, and more specifically, relates to an eye massage medium, its preparation method and application. Background Technology

[0002] Pediatric massage is a traditional Chinese medicine method for children's health care and treatment. Through specific techniques, it stimulates acupoints around the eyes, effectively relieving eye strain, dry eyes, and refractive errors in children. During the massage, a pure Chinese herbal compound medium not only serves as a lubricant between the massage techniques and the skin but also promotes transdermal drug penetration through the massage. The activity and texture of its components directly affect the final effect of the massage.

[0003] Currently available pediatric eye massage mediums are mostly limited to lubrication or mild cooling stimulation in terms of efficacy, lacking targeted external herbal formulas guided by the holistic diagnostic principles of Traditional Chinese Medicine. In terms of preparation processes, most use conventional grinding methods, resulting in coarse raw material particles (usually 80-120 mesh), leading to low dissolution rates of active ingredients and hindering their full pharmacological effects. Furthermore, some mediums contain added artificial chemical components, which may pose a risk of irritation to the delicate eye mucosa of children.

[0004] With the application of AI technology in pediatric massage, automated massage equipment has higher requirements for the uniformity and adhesion of the massage medium. Mediums prepared using conventional grinding processes are prone to uneven application and rapid loss during massage. Meanwhile, parents' demand for natural, highly effective herbal mediums is increasing, and existing products struggle to meet the triple requirements of "high activity, high compatibility, and high safety." Therefore, there is an urgent need for an eye massage medium that employs advanced extraction technology and a scientifically formulated recipe to address the shortcomings of existing eye massage mediums. Summary of the Invention

[0005] The purpose of this invention is to provide an eye massage medium, its preparation method, and its application. By using an ultra-micro extraction process to improve the utilization rate of the effective components of the raw materials, and by using a rationally designed herbal formula to optimize the compatibility and safety of the medium, this invention solves the technical problems of low activity of effective components, poor compatibility with automated massage equipment, and unsatisfactory safety of existing eye massage mediums.

[0006] To achieve the above objectives, a first aspect of the present invention provides a method for preparing an eye massage medium, comprising the following steps:

[0007] Under nitrogen protection, the herbal mixture is ultra-finely pulverized to obtain a mixed ultra-fine powder; the herbal mixture consists of the following parts by weight: 2-4 parts of peppermint, 7-11 parts of borneol, 7-11 parts of buddleja officinalis, 7-11 parts of vitex trifolia, 18-22 parts of cassia seed, 4-6 parts of chrysanthemum, and 4-6 parts of Eucommia ulmoides.

[0008] Ethanol was added to the mixed ultrafine powder, and ultrasonic-assisted extraction was performed at 35-40°C to obtain an extract.

[0009] The extract is filtered to remove impurities, resulting in a filtrate.

[0010] The filtrate was concentrated under reduced pressure to obtain compound extract powder;

[0011] The compound extract powder, selenium peptide, and medical petrolatum were mixed evenly to obtain a paste-like eye massage medium.

[0012] Furthermore, the ultrasonic-assisted extraction uses 70% ethanol as the extraction solvent.

[0013] Furthermore, the mass ratio of the compound extract powder, the selenium peptide, and the medical petrolatum is 10-14:1:20-24.

[0014] Furthermore, the ultrasonic-assisted extraction is performed twice, and the extracts from the two extractions are combined to obtain the final extract.

[0015] Furthermore, the ultrasonic-assisted extraction is carried out under an inert atmosphere.

[0016] Furthermore, the vacuum concentration is carried out under conditions of temperature ≤60℃ and vacuum degree -0.08MPa.

[0017] Furthermore, the ultrafine pulverization is carried out in a WFJ-15 type ultrafine pulverizer with a rotation speed of 30,000-35,000 r / min and a pulverization time of 30-40 minutes, while maintaining the internal temperature of the machine at ≤45℃ during the pulverization process.

[0018] Furthermore, during the ultrafine pulverization process, borneol is added 5-10 minutes before the pulverization is completed.

[0019] Furthermore, before the ultrafine pulverization, a pretreatment step is included for the herbal mixture raw materials. The pretreatment includes: removing moldy and insect-infested parts from the raw materials; rinsing the raw materials with purified water 2-3 times, each time for 10-15 seconds; and vacuum drying the drained raw materials at a temperature of 60-70℃, a vacuum degree of -0.08~-0.09MPa, and a drying time of 2-3 hours until the moisture content is ≤5%.

[0020] In a second aspect, the present invention provides an eye massage medium, which is obtained by any of the preparation methods described above.

[0021] In a third aspect, the present invention provides an application of an eye massage medium in pediatric eye massage, wherein the eye massage medium is used in conjunction with an automated massage device for massage.

[0022] Compared with the prior art, the present invention has the following technical effects:

[0023] This invention discloses an eye massage medium formulated according to the traditional Chinese medicine principle of "principal, assistant, adjuvant, and guide." Cassia seed is the principal ingredient, possessing the core effects of clearing the liver and improving eyesight, and nourishing the eye orifices. Honeysuckle, chrysanthemum, Eucommia ulmoides, and selenium peptide are the assistant ingredients, synergistically clearing heat and moisturizing dryness, dispersing wind-heat, and also improving eyesight and removing corneal opacity. Vitex trifolia is the adjuvant ingredient, possessing the effects of clearing the head and eyes and guiding the medicinal effects upwards. Peppermint and borneol are the guiding ingredients, possessing the effects of directing the medicine to the eyes, enhancing skin penetration, relieving eye muscle fatigue, and reducing inflammation and swelling. The combined effects of these components achieve the functions of clearing the liver and improving eyesight, dispersing wind-heat, moisturizing and protecting the eyes, and reducing inflammation and soothing. This eye massage medium can effectively improve eye fatigue and dryness in children. It is safe and efficient in clinical application, and has good compatibility with automated massage equipment. During the massage process, the medium does not stick, dry out, clump, or leak, and the medium layer thickness is uniform and stable.

[0024] The present invention discloses a method for preparing an eye massage medium by first subjecting the herbal mixture to ultra-fine pulverization to significantly increase the dissolution of active ingredients, followed by low-temperature ultrasonic-assisted extraction, eliminating the need for high-temperature decoction, maximizing the retention of heat-sensitive active ingredients, and enhancing the pharmacological effect of the medium. Detailed Implementation

[0025] To make the technical problem to be solved, the technical solution, and the beneficial effects of the present invention clearer, the present invention will be further described in detail below with reference to embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the present invention and are not intended to limit the present invention.

[0026] The terminology used in the embodiments of this invention is for the purpose of describing particular embodiments only and is not intended to limit the invention. The singular forms “a,” “the,” and “the” as used in the embodiments of this invention and the appended claims are also intended to include the plural forms unless the context clearly indicates otherwise.

[0027] This invention provides an eye massage medium and its preparation method, comprising the following steps:

[0028] S1. Raw Material Pretreatment: The herbal mixture is pretreated, including: accurately weighing each raw material according to the weight parts, manually removing moldy and insect-infested parts; quickly rinsing the raw materials with purified water 2-3 times, 10-15 seconds each time, to avoid loss of effective ingredients, and then draining the surface moisture with sterile gauze; placing the drained raw materials into a vacuum drying oven for vacuum drying at a temperature of 60-70℃, a vacuum degree of -0.08~-0.09MPa, and a drying time of 2-3 hours, until the moisture content is ≤5%; the herbal mixture consists of the following raw materials in the weight parts: peppermint 2-4 parts, borneol 7-11 parts, buddleja officinalis 7-11 parts, vitex trifolia 7-11 parts, cassia seed 18-22 parts, chrysanthemum 4-6 parts, and eucommia ulmoides 4-6 parts;

[0029] S2. Ultrafine grinding + ultrasonic extraction: The dried herbal mixture is transferred to a WFJ-15 ultrafine grinder for ultrafine grinding, and nitrogen gas (flow rate 1-2L / min) is introduced for protection to prevent oxidation of volatile components such as borneol; the mixture is passed through a 200-300 mesh sieve to obtain a mixed ultrafine powder; ethanol is added to the mixed ultrafine powder, and ultrasonic-assisted extraction is performed at 35-40℃ to obtain an extract;

[0030] S3. Filtration and impurity removal: Filter the extract to remove impurities and obtain the filtrate;

[0031] S4. Concentration under reduced pressure: The filtrate is concentrated under reduced pressure to obtain compound extract powder;

[0032] S5. Medium preparation: Mix the compound extract powder, selenium peptide and medical petrolatum in a sealed container at 45-55℃ to obtain a paste-like eye massage medium.

[0033] S6. Finished product packaging: While the prepared medium is still hot, it is put into a sterile sealed container, and after naturally cooling to room temperature, it is stored in the dark and refrigerated.

[0034] In step S2 above, the ultrafine pulverizer operates at a speed of 30,000-35,000 r / min and a pulverization time of 30-40 minutes. During pulverization, temperature is controlled by circulating cold water to maintain the internal temperature ≤45℃, preventing damage to heat-sensitive components. After pulverization, the mixture is passed through a 200-300 mesh standard sieve to collect the ultrafine powder. The coarse powder remaining on the sieve is returned to the pulverizer for secondary pulverization. During the ultrafine pulverization process, borneol is preferably added 5-10 minutes before the end of pulverization, i.e., in the later stages of pulverization, to reduce its volatility loss and ensure the anti-inflammatory and anti-swelling effects of the medium.

[0035] Ultrasonic-assisted extraction uses 70% ethanol as the extraction solvent, suitable for dissolving multiple components such as volatile oils, flavonoids, and saponins. The mass ratio of extraction solvent to mixed ultrafine powder is 8:1. Ultrasonic extraction is conducted at a low temperature (35~40℃) throughout the process, allowing for two extractions: a first extraction of 30 min and a second extraction of 20 min. The extracts from both extractions are then combined. Before each extraction, a small amount of inert gas can be introduced to replace the air above the extract, ensuring the extraction is carried out under an inert atmosphere and reducing the loss of menthol and borneol through volatilization.

[0036] In this step, by pulverizing the raw materials to 200-300 mesh with a particle size of 1-5μm, the specific surface area of ​​the raw materials is greatly increased, which significantly improves the dissolution of the effective components. Moreover, high-temperature decoction is not required, maximizing the retention of heat-sensitive active ingredients and enhancing the pharmacological effect of the medium.

[0037] In step S3 above, filtration is performed using multi-layer sterile filter cloth (5μm pore size). Through the physical retention of the filter cloth, incompletely crushed raw material particles, fibrous impurities, and a small amount of precipitate in the extract are removed, ensuring that the filtrate is clear and free of impurities, and the filtrate is collected.

[0038] In step S4 above, the vacuum concentration is carried out under conditions of temperature ≤60℃ and vacuum degree -0.08MPa. A highly active compound extract powder is obtained through vacuum concentration.

[0039] In step S5 above, the mass ratio of compound extract powder, selenium peptide, and medical petrolatum is 10-14:1:20-24, preferably 12:1:22. The medium is prepared in a constant-temperature stirrer at 400-500 rpm for 25-35 minutes until a uniform paste is formed. During this process, the stirrer is stopped for 1 minute every 5 minutes to manually stir the material at the edges, ensuring complete integration of the compound extract powder, selenium peptide, and medical petrolatum to form a fine, particle-free paste. The medical petrolatum used is food-grade pure white petrolatum, free of fragrances and preservatives. The selenium peptide can be one or a combination of two or more of the following: selenized fish skin collagen peptide, selenized egg white peptide, selenized soybean peptide, and selenized corn peptide. In a specific embodiment of this invention, the selenium peptide is glutathione peroxidase (GPX4).

[0040] In step S6 above, the paste medium is packed into sterile glass jars or aluminum foil bags while it is still hot (40-45℃), with each jar / bag containing 5-10g. After naturally cooling to room temperature, it is stored in the refrigerator at 4-8℃ for 12 months.

[0041] The eye massage medium of this invention is formulated according to the traditional Chinese medicine theory of "principal, assistant, adjuvant, and guide". Cassia seed is the principal ingredient, which has the core effects of clearing the liver and improving eyesight, and nourishing the eyes. Honeysuckle, chrysanthemum, Eucommia ulmoides, and selenium peptide are the assistant ingredients, which work together to clear heat and moisten dryness, disperse wind-heat, and improve eyesight and remove corneal opacity. Vitex trifolia is the adjuvant ingredient, which has the effects of clearing the head and eyes and guiding the medicinal effects upward. Peppermint and borneol are the guide ingredients, which have the effects of guiding the medicine directly to the eyes, enhancing skin penetration, relieving eye muscle fatigue, and reducing inflammation and swelling. The above ingredients work together to achieve the effects of clearing the liver and improving eyesight, dispersing wind-heat, moisturizing and protecting the eyes, and reducing inflammation and soothing.

[0042] The pharmacological effects of each herbal ingredient in the eye massage medium of this invention are as follows:

[0043] Cassia seed: It is sweet, bitter, and salty in taste, and slightly cold in nature. It enters the liver and large intestine meridians. It contains active ingredients such as cassia seed extract and rhein, which can clear liver fire, improve eyesight and remove corneal opacity. It is effective for red, swollen and painful eyes, blurred vision and eye fatigue caused by liver heat or wind-heat. At the same time, it can moisten the intestines and promote bowel movements, reduce liver fire caused by constipation in children, and indirectly help improve eye symptoms.

[0044] Honeysuckle flower: It is sweet and slightly cold in nature, and enters the liver and gallbladder meridians; it contains ingredients such as honeysuckle glycoside and apigenin, and is good at clearing liver fire, improving eyesight and moisturizing dryness. Its medicinal properties are mild and suitable for children's constitution, and can enhance the liver-clearing and vision-improving effects of the principal medicine. It is especially suitable for discomforts such as dry eyes and blurred vision.

[0045] Chrysanthemum: It is sweet and bitter in taste, slightly cold in nature, and enters the lung and liver meridians. It contains volatile oil and flavonoids, which can not only work with the principal medicine to soothe the liver and improve eyesight, but also disperse wind-heat and relieve mild congestion and photophobia of the eyes caused by exogenous wind-heat, thus taking into account both clearing heat and protecting the eyes.

[0046] Qingqianliu: It is bitter and neutral in nature, and enters the liver meridian. It contains flavonoids, triterpenoids and phenolic acids, which can work with the principal medicine to clear the liver and improve eyesight, and dredge the eye meridians. It can also clear heat and calm the liver, and relieve eye swelling, dryness and eye fatigue caused by liver heat or poor eye meridians. It has the effects of clearing and purging.

[0047] Selenium peptides: The components are selenium and bioactive peptides; they have the functions of nourishing yin and improving eyesight, detoxifying and moisturizing the eyes. They can act as a micro-carrier to enhance transdermal penetration and nourishment in conjunction with the principal and assistant drugs, and can also reduce oxidative damage to the eyes through their antioxidant activity, and help improve dry eyes and visual function, thus playing a dual role of drug delivery and eye protection.

[0048] Vitex trifolia: It is pungent, bitter and slightly cold in nature, and enters the bladder, liver and stomach meridians; it contains vitex flavonoids and volatile oil, which can dispel wind-heat and clear the head and eyes. Its pungent and dispersing nature can guide the efficacy of the principal and assistant medicines to the eyes, enhance the local effect, and at the same time relieve dizziness and irritability caused by eye discomfort.

[0049] Peppermint: It is pungent and cool in nature, and enters the lung and liver meridians; it contains menthol, which is light and ascending, serving as a guide for the medicine to reach the eyes directly, quickly producing a cooling sensation, relieving eye muscle spasms, alleviating eye fatigue, improving the comfort during massage, and at the same time helping to disperse wind-heat in the eyes.

[0050] Borneol: It is pungent, bitter, and slightly cold in nature, and enters the heart, spleen, and lung meridians; it contains borneol and isoborneol, which can reduce inflammation and swelling, clear the head and eyes, and significantly enhance skin permeability, promote the absorption of other ingredients, improve the overall efficacy, and relieve mild inflammatory reactions in the eyes.

[0051] The massage medium preparation method of this invention maximizes the retention of effective components of raw materials and enhances the pharmacological activity of the medium through ultra-micro extraction technology. The massage medium of this invention uses natural herbs as its core, formulated according to the principles of traditional Chinese medicine (TCM) for the synergistic effects of clearing the liver and improving eyesight, dispersing wind-heat, relieving eye fatigue, and reducing inflammation and moisturizing the eyes. The combination of herbs is tailored to the physiological characteristics of children's eyes. The ultra-micro extraction process results in finer raw material particles and a higher dissolution rate of effective components. Combined with medical-grade petroleum jelly, the medium has a delicate texture, is easy to apply, and is non-irritating. It is compatible with the automated massage process of AI-powered intelligent pediatric massage devices, effectively improving problems such as visual fatigue and dry eyes in children. This addresses the shortcomings of existing pediatric massage mediums, such as low utilization rate of effective components and poor compatibility, making it safe and efficient for clinical application. The massage medium of this invention is suitable for eye massage in children aged 6-18 years and can be used in conjunction with the acupoint positioning and intensity adjustment functions of AI-powered intelligent pediatric massage devices.

[0052] The following examples illustrate an eye massage medium and its preparation method according to embodiments of the present invention.

[0053] Example 1

[0054] Embodiment 1 of the present invention provides an eye massage medium and its preparation method, comprising the following steps:

[0055] S1. Raw material pretreatment: Weigh the corresponding raw materials according to the following weight parts: 3 parts peppermint, 9 parts borneol, 9 parts buddleja officinalis, 9 parts vitex trifolia, 20 parts cassia seed, 5 parts chrysanthemum, and 5 parts Eucommia ulmoides. After removing impurities, rinse twice with purified water and drain. Vacuum dry at 60℃ for 3 hours until the moisture content is ≤5%.

[0056] S2. Ultrafine grinding + ultrasonic extraction: The dried raw material is transferred to an ultrafine grinder and ground at 30,000 r / min for 40 minutes under nitrogen protection, with the temperature controlled at ≤40℃. The powder is then passed through a 200-mesh sieve. For each extraction, 8 times the amount of 70% ethanol is added, and the extraction is carried out twice at 35~40℃. The first extraction is for 30 min, and the second extraction is for 20 min. The extracts from the two extractions are combined to obtain the extract. After filtering to remove impurities, the extract is concentrated under reduced pressure at ≤60℃ and a vacuum degree of -0.08MPa to collect the compound extract powder.

[0057] S3. Medium preparation: Mix 60 g of compound extract powder, 5 g of selenium peptide and 110 g of medical petroleum jelly, stir at 45℃ and 400 r / min for 35 minutes to make a paste-like medium; the selenium peptide is glutathione peroxidase GPX4.

[0058] S4. Finished product packaging: Pack into 10g sterile aluminum foil bags and store in the refrigerator.

[0059] The massage medium prepared in this embodiment of the invention has a particle size of approximately 5 μm. Quantitative detection was performed using high-performance liquid chromatography (HPLC). By comparing the menthol content in the medium obtained by the ultra-micro extraction process of this embodiment with that obtained by conventional grinding, it was calculated that the menthol dissolution rate was increased by 32% compared to conventional grinding. The duration of the cooling sensation after application was extended by 1.5 times compared to conventional grinding. It was compatible with the massage head movement speed (2-5 cm / s) of the smart AI eye massager (apple rabbit-VA02050824), and no adhesion or loss of the medium was observed during the massage process.

[0060] The conventional grinding process for preparing massage media is as follows:

[0061] Weigh out the corresponding amounts of raw materials according to their weight: 3 parts peppermint, 9 parts borneol, 9 parts buddleja officinalis, 9 parts vitex trifolia, 20 parts cassia tora, 5 parts chrysanthemum, and 5 parts Eucommia ulmoides. After removing impurities, rinse twice with purified water and drain. Vacuum dry at 60℃ for 3 hours until the moisture content is ≤5%. Grind the dried raw materials through an 80-mesh sieve at ≤40℃ to obtain fine powder. Mix 60 g of the fine powder, 5 g of selenium peptide, and 110 g of medical petroleum jelly, and stir at 45℃ and 400 r / min for 35 minutes to make a paste-like medium, thus obtaining a massage medium prepared by conventional grinding process.

[0062] Example 2

[0063] Embodiment 2 of the present invention provides an eye massage medium and its preparation method, comprising the following steps:

[0064] S1. Raw material pretreatment: Weigh the corresponding raw materials according to the following weight parts: 2 parts peppermint, 7 parts borneol, 7 parts buddleja officinalis, 7 parts vitex trifolia, 18 parts cassia seed, 4 parts chrysanthemum, and 5 parts Eucommia ulmoides. After removing impurities, rinse 3 times with purified water and drain. Vacuum dry at 65℃ for 2.5 hours until the moisture content is ≤5%.

[0065] S2. Ultrafine grinding + ultrasonic extraction: The dried raw material is transferred to an ultrafine grinder and ground at 32,000 r / min for 35 minutes under nitrogen protection, with the temperature controlled at ≤40℃. The powder is then passed through a 250-mesh sieve. For each extraction, 8 times the amount of 70% ethanol is added, and the extraction is carried out twice at 35~40℃. The first extraction is for 30 min, and the second extraction is for 20 min. The extracts from the two extractions are combined to obtain the extract. After filtering to remove impurities, the extract is concentrated under reduced pressure at ≤60℃ and a vacuum degree of -0.08MPa to collect the compound extract powder.

[0066] S3. Medium preparation: Mix 60 g of compound extract powder, 5 g of selenium peptide and 110 g of medical petroleum jelly, stir at 50℃ and 450 r / min for 30 minutes to make a paste-like medium; the selenium peptide is glutathione peroxidase GPX4.

[0067] S4. Finished product packaging: Dispense into 10g sterile glass jars and store under cold storage.

[0068] The massage medium prepared in this embodiment of the invention has a particle size of approximately 3 μm. Sample solutions of the massage medium group and the conventional grinding group of this invention were prepared separately, reacted with a colorimetric agent, and the absorbance was measured at 510 nm using a UV spectrophotometer. The flavonoid content was calculated by substituting the absorbance into a standard curve (using rutin as the standard substance). The dissolution rate of flavonoid components was obtained by calculating (content of massage medium group - content of conventional grinding group) / content of conventional grinding group × 100%. By comparing the flavonoid content in the medium obtained by the ultra-micro extraction process of this embodiment of the invention with that obtained by the conventional grinding process, the flavonoid dissolution rate was found to be 45% higher than that obtained by conventional grinding. Clinical use statistics show that the medium prepared in this embodiment of the invention has an effective rate of 92% in improving symptoms of dry eyes in children. It is compatible with the pressure sensor (0.1-0.3N) of the smart AI eye care device (apple rabbit-VA02050824), and the thickness of the medium layer remains stable during massage.

[0069] The preparation of the conventional grinding media samples is the same as in Example 1.

[0070] Example 3

[0071] Embodiment 3 of the present invention provides an eye massage medium and its preparation method, comprising the following steps:

[0072] S1. Raw material pretreatment: Weigh the corresponding raw materials according to the following weight parts: 4 parts peppermint, 11 parts borneol, 11 parts buddleja officinalis, 11 parts vitex trifolia, 22 parts cassia tora, 6 parts chrysanthemum, and 5 parts Eucommia ulmoides. After removing impurities, rinse twice with purified water and drain. Vacuum dry at 70℃ for 2 hours until the moisture content is ≤5%.

[0073] S2. Ultrafine grinding + ultrasonic extraction: The dried raw material is transferred to an ultrafine grinder and ground at 35,000 r / min for 30 minutes under nitrogen protection. Borneol is added in the last 8 minutes. The temperature is controlled at ≤38℃. The powder is passed through a 300-mesh sieve. Each extraction is performed by adding 8 times the amount of 70% ethanol and extracting twice at 35~40℃. The first extraction is 30 min and the second extraction is 20 min. The extracts from the two extractions are combined to obtain the extract. After filtering to remove impurities, the extract is concentrated under reduced pressure at ≤60℃ and a vacuum degree of -0.08MPa to collect the compound extract powder.

[0074] S3. Medium preparation: Mix 60 g of compound extract powder, 5 g of selenium peptide and 110 g of medical petroleum jelly, stir at 55℃ and 500 r / min for 25 minutes to make a paste-like medium; the selenium peptide is glutathione peroxidase GPX4.

[0075] S4. Finished product packaging: Pack into 10g sterile aluminum foil bags and store in the refrigerator.

[0076] The massage medium prepared in this embodiment of the invention has a particle size of approximately 1 μm. The finished medium prepared in this embodiment of the invention was extracted with ethyl acetate using gas chromatography, and the borneol content was then determined. Based on the total theoretical effective component (borneol) of borneol in the raw material (purity ≥ 98%), the retention rate of the effective component (borneol) was calculated as (actual borneol content in the finished product ÷ theoretical total) × 100%, resulting in a borneol effective component retention rate of 90%.

[0077] A mild ocular inflammation model was established in mice: SPF-grade Kunming mice or ICR mice, regardless of sex, weighing 18-25g, were selected and acclimatized for 3-5 days in a constant temperature and humidity environment with free access to food and water. Mice were randomly divided into a normal control group and a model group. The normal control group received no treatment, while the model group underwent modeling. Mice in the model group were locally anesthetized (using oxybuprocaine hydrochloride eye drops), and then 10μL of 1% carrageenan saline solution was slowly injected subconjunctiva of the lower eyelid using a microsyringe. Ocular signs were observed under a slit-lamp microscope 6-12 hours after modeling. Inflammation was scored using the following criteria: conjunctival hyperemia, slight eyelid swelling, and a small amount of discharge, with an inflammation score of 1-2, were considered as successful modeling.

[0078] The scoring is based on observations under a slit-lamp microscope. The scoring criteria for ocular / corneal inflammation mainly include the following three dimensions:

[0079]

[0080] Total score calculation: Add up the scores of the above 4 items, and the total score ranges from 0 to 12 points.

[0081] Successful modeling is defined as conjunctival hyperemia, slight eyelid swelling, a small amount of discharge, and an inflammation score of 1-2.

[0082] Mice that successfully developed the model were divided into an experimental group (using the medium prepared in Example 3 of this invention) and a control group (using conventional grinding medium, prepared in the same way as in Example 1). Both groups underwent the same hand massage procedure. The area of ​​redness and swelling reduction and the content of inflammatory factors at the inflammatory sites were measured in both groups. The results were calculated as (anti-inflammatory effect index of experimental group - index of control group) ÷ index of control group × 100%, and the results are shown in the table below.

[0083]

[0084] As shown in the table above, the anti-inflammatory effect of the experimental group was about 50% higher than that of conventional grinding media. Furthermore, the massage media prepared in this embodiment of the invention was adapted to the AI ​​intelligent pediatric massage device (apple rabbit-VA02050824) for continuous massage for 10-15 minutes, and no drying or clumping was observed during the massage.

[0085] Comparative Example 1

[0086] The difference between this and Example 1 is that the raw materials do not contain cassia seeds.

[0087] Comparative Example 2

[0088] The difference between this and Example 1 is that the raw materials do not contain buddleja flowers.

[0089] Comparative Example 3

[0090] The difference between this and Example 1 is that the raw materials do not contain chrysanthemum.

[0091] Comparative Example 4

[0092] Medical-grade petroleum jelly is used directly as the massage medium.

[0093] Comparative Example 5

[0094] The difference between this and Example 1 is that the raw materials do not contain Eucommia ulmoides.

[0095] Comparative Example 6

[0096] The difference between this and Example 1 is that no selenium peptide is added in the medium modulation step.

[0097] Experimental Group 1

[0098] Sixty children aged 6-18 years with eye strain were randomly divided into two groups: an experimental group and a control group, with 30 children in each group. The experimental group used the massage medium prepared in Example 1 of this invention in conjunction with an AI intelligent pediatric massage device (apple rabbit-VA02050824, massage acupoints: Jingming, Zanzhu, Taiyang), for 15 minutes each time, 3 times a week. The control group used conventional grinding media (prepared as in Example 1), with other conditions remaining the same. After 4 weeks, the results showed that the eye strain relief rate in the experimental group was 93.3% (compared to 66.7% in the control group), and the dry eye improvement rate was 90% (compared to 60% in the control group). Furthermore, no children in the experimental group experienced eye irritation, demonstrating significantly better safety and efficacy than the control group.

[0099] Dry eyes are the most common and dominant symptom of eye strain. The improvement rate data of dry eyes highlights the therapeutic effect of the massage medium in the embodiments of the present invention.

[0100] Experimental Group 2

[0101] To verify the necessity of the core components (cassia seed, honeysuckle, chrysanthemum, Eucommia ulmoides, and selenium peptide) in the massage medium formula of this invention for relieving visual fatigue in children, five comparative groups (i.e., comparative groups 1-3, 5, and 6, each lacking a single core component) and one blank group (i.e., comparative group 4) were added, with 30 people in each group. They were compared with Example 1. All groups used the in-group medium in conjunction with the AI ​​intelligent pediatric massage device (apple rabbit-VA02050824, massage acupoints: Jingming, Zanzhu, and Taiyang) for 15 minutes each time, 3 times a week. After 4 weeks of operation, the efficacy of relieving visual fatigue was observed.

[0102] The relevant case sources and diagnostic criteria in Experimental Group 1 and Experimental Group 2 are as follows:

[0103] 1. Case source: A total of 240 myopic adolescent patients from an ophthalmology hospital in Wuhan were collected from March 2025 to July 2025.

[0104] 2. Diagnostic criteria for eye strain: The presence of ≥3 out of 6 symptoms, including dry eyes, eye irritation, blurred vision, eye soreness, photophobia, and frequent blinking, and the duration of these symptoms is ≥2 hours per day;

[0105] 3. Exclusion criteria:

[0106] 1) Those whose diagnoses and inclusion criteria do not match the above criteria;

[0107] 2) Those who use other treatment methods to control myopia progression within one month;

[0108] 3) The patient has other systemic diseases or mental illnesses;

[0109] 4) Patients with other eye diseases besides myopia (such as exotropia, latent strabismus greater than 5°, strabismic amblyopia, active ocular inflammation, etc.) that affect the assessment of treatment efficacy.

[0110] 4. Efficacy criteria:

[0111] Significant effect: Symptoms of eye strain disappear;

[0112] Effective: Relieves symptoms of eye strain;

[0113] Ineffective: Visual fatigue is not relieved or may even worsen.

[0114] 5. Grouping and Experimental Methods

[0115] Patients included in the observation were randomly divided into seven groups of 30 each. All cases completed the entire treatment with no dropouts. Before treatment, there were no statistically significant differences in the results of various examinations between the two groups, making the data comparable. Five control groups (each lacking a single core component) and one control group (control group 4) were compared with Example 1. All groups used the same AI intelligent pediatric massage device (apple rabbit-VA02050824), and the intervention plan was consistent with Example 1 (same acupoints, duration, and frequency of massage). The efficacy in relieving visual fatigue was observed.

[0116] 6. Statistical methods

[0117] Data processing was performed using SPSS 17.0 software. Paired t-tests were used to compare pre- and post-treatment measurement data within each group, and ANOVA was used for inter-group comparisons. The significance level was set at α=0.05, and p<0.05 was considered statistically significant.

[0118] 7. Experimental Results

[0119]

[0120] 8. Conclusion

[0121] 1) Comparative Example 1 (without cassia seed): The total effective rate was only 55.6% of the experimental group, which verifies that cassia seed is the core principal ingredient of the formula and its liver-clearing and vision-improving effects are irreplaceable.

[0122] 2) Comparative Example 2 / 3 (without Buddleja officinalis / Chrysanthemum): The overall effective rate was 20% lower than that of the experimental group, indicating that the auxiliary drug can significantly enhance the core efficacy, and the efficacy decreases after its absence.

[0123] 3) Comparative Example 5 (without Eucommia ulmoides): The total effective rate dropped to 70.0%, which was 20% lower than that of the experimental group. This indicates that Eucommia ulmoides, as an adjuvant drug, can assist in clearing the liver and moisturizing dryness, and enhance the effect of relieving eye fatigue. Its efficacy was significantly reduced after its absence.

[0124] 4) Comparative Example 6 (without selenopeptide): The total effective rate decreased to 63.3%, which was 26.7% lower than that of the experimental group. This verifies that selenopeptide can promote the absorption of herbal active ingredients and improve the safety of the medium. It is an important component that assists in the efficacy of the medicine. After its absence, both the efficacy and absorption effect decreased.

[0125] 5) Comparative Example 4 (medical petroleum jelly only): The total effective rate was only 6.7%, and there were no cases of significant effect. This verifies that the herbal compound extract powder is the core basis for the efficacy of the medium in the embodiments of this invention, and the medical petroleum jelly matrix alone has no substantial improvement effect.

[0126] The above embodiments merely illustrate several implementation methods of the present invention, and their descriptions are relatively specific and detailed, but they should not be construed as limiting the scope of the present invention. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these all fall within the protection scope of the present invention. Therefore, the protection scope of this patent should be determined by the appended claims.

Claims

1. A method for preparing an eye massage medium, characterized in that, Includes the following steps: Under nitrogen protection, the herbal mixture was ultra-finely pulverized to obtain a mixed ultra-fine powder; The herbal mixture consists of the following ingredients in parts by weight: 2-4 parts peppermint, 7-11 parts borneol, 7-11 parts buddleja officinalis, 7-11 parts vitex trifolia, 18-22 parts cassia tora, 4-6 parts chrysanthemum, and 4-6 parts Eucommia ulmoides. Ethanol was added to the mixed ultrafine powder, and ultrasonic-assisted extraction was performed at 35-40°C to obtain an extract. The extract is filtered to remove impurities, resulting in a filtrate. The filtrate was concentrated under reduced pressure to obtain compound extract powder; The compound extract powder, selenium peptide, and medical petrolatum were mixed evenly to obtain a paste-like eye massage medium.

2. The method for preparing an eye massage medium as described in claim 1, characterized in that, The ultrasound-assisted extraction uses 70% ethanol as the extraction solvent; and / or the mass ratio of the compound extract powder, the selenium peptide, and the medical petrolatum is 10-14:1:20-24.

3. The method for preparing an eye massage medium as described in claim 2, characterized in that, The ultrasonic-assisted extraction is performed twice, and the extracts from the two extractions are combined to obtain the final extract.

4. The method for preparing an eye massage medium as described in claim 2, characterized in that, The ultrasonic-assisted extraction was carried out under an inert atmosphere.

5. The method for preparing an eye massage medium as described in claim 1, characterized in that, The vacuum concentration was carried out under conditions of temperature ≤60℃ and vacuum degree -0.08MPa.

6. The method for preparing an eye massage medium as described in claim 1, characterized in that, The ultrafine pulverization is carried out in a WFJ-15 ultrafine pulverizer at a speed of 30,000-35,000 r / min and a pulverization time of 30-40 minutes, while maintaining the internal temperature of the machine at ≤45℃ during the pulverization process.

7. The method for preparing an eye massage medium as described in claim 1, characterized in that, During the ultrafine pulverization process, borneol is added 5-10 minutes before the pulverization is completed.

8. A method for preparing an eye massage medium as described in any one of claims 1-7, characterized in that, Before the ultrafine pulverization, the herbal mixture is further subjected to a pretreatment step, which includes: removing moldy and insect-infested parts from the raw materials; rinsing the raw materials with purified water 2-3 times, each time for 10-15 seconds; and vacuum drying the drained raw materials at a temperature of 60-70℃, a vacuum degree of -0.08 to -0.09 MPa, and a drying time of 2-3 hours until the moisture content is ≤5%.

9. An eye massage medium, characterized in that, It is obtained by the preparation method according to any one of claims 1-8.

10. The application of the eye massage medium as described in claim 9 in pediatric eye massage, characterized in that, The eye massage medium is used in conjunction with automated massage equipment for massage.

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