一种相思子碱-壳聚糖 / 碳酸钙止血海绵及其制备方法和应用
By preparing abrin-chitosan/calcium carbonate hemostatic sponge, combining the condensation reaction of chitosan and abrin with the coagulation effect of calcium carbonate, the problems of hemostasis during liver cancer surgery and postoperative tumor recurrence were solved, achieving a multifunctional effect of rapid hemostasis and tumor inhibition.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- GUANGXI UNIV OF CHINESE MEDICINE
- Filing Date
- 2026-05-06
- Publication Date
- 2026-07-17
AI Technical Summary
Existing hemostatic materials have limited hemostatic effect in liver cancer surgery and increase the risk of bleeding during tumor resection and postoperative tumor recurrence. There is a lack of effective products that combine hemostasis and prevention of tumor recurrence.
By condensing abrin with chitosan to form a brusin-chitosan complex, and then combining it with calcium carbonate, a brusin-chitosan/calcium carbonate hemostatic sponge was prepared. The intelligent controlled release of brusin was achieved by utilizing the condensation reaction between the amino group of chitosan and the carboxyl group of abrin under acidic conditions. Combined with the hemostatic effect of calcium carbonate, a hemostatic sponge was formed.
It achieves rapid hemostasis during liver cancer surgery and reduces the risk of postoperative tumor recurrence by controlling the release of abrin through pH sensitivity. It provides a "one-stop" strategy for intraoperative hemostasis and postoperative prevention of tumor recurrence, and has significant antibacterial properties and tumor-suppressing effects.
Smart Images
Figure CN122140993B_ABST