一种轮辐状脱细胞角膜及其制备方法和应用
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SICHUAN UNIV
- Filing Date
- 2026-05-07
- Publication Date
- 2026-07-17
AI Technical Summary
Existing decellularization techniques suffer from uneven decellularization in the cornea, leading to the loss of bioactive components and reduced mechanical properties in the periphery of the cornea. Traditional methods are also ineffective in removing cellular components from the central region of the cornea.
Low thermal conductivity insulating material is applied to the upper and lower surfaces of the cornea. A corneal trephine is used to cut and construct spoke-shaped microchannels in a low-temperature environment. The growth of ice crystals is controlled by a directional temperature field to form directional microchannels, thereby improving decellularization efficiency and promoting host cell migration.
It achieves efficient removal of cellular components in the central part of the cornea, avoids the loss of bioactive components in the peripheral area, and enhances the biointegration and mechanical stability of the transplanted cornea and the recipient.
Smart Images
Figure CN122141013B_ABST