一种负载血管化鼻黏膜类器官微胶囊的制备方法及其应用
Core-shell hydrogel microcapsules prepared using coaxial microfluidic electrospray technology have solved the problems of survival rate and vascularization during in vivo transplantation of nasal mucosal organoids, achieving effective repair and functional recovery of nasal mucosal wounds.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY (SHANDONG PROVINCIAL HOSPITAL)
- Filing Date
- 2026-05-11
- Publication Date
- 2026-07-17
AI Technical Summary
In existing technologies, nasal mucosal organoids have low survival rates, insufficient nutrient supply, and limited vascularization during in vivo transplantation, resulting in limited therapeutic effects. Furthermore, traditional microcapsule systems are insufficient in loading complex three-dimensional organoid structures and promoting vascularization.
Core-shell structured hydrogel microcapsules were prepared using coaxial microfluidic electrospray technology. By preparing internal and external phase solutions, the vascularized nasal mucosa organoid microcapsules were formed in calcium chloride collection solution using electrospray technology, ensuring the stability and vascularization of the organoids in vivo.
It improves the survival rate and vascularization of nasal mucosal organoids, promotes the healing and functional repair of nasal mucosal wounds, and has good biocompatibility and safety, making it suitable for the treatment of nasal mucosal injuries.
Smart Images
Figure CN122141014B_ABST