An immunomodulatory protein fip-ss14b derived from medicinal fungus phellinus baumii and application thereof

Abstract

This invention relates to the fields of genetic engineering and microbial technology, and provides an immunomodulatory protein FIP-SS14b derived from Phellinus linteus and its applications. The amino acid sequence of this immunomodulatory protein FIP-SS14b corresponds to SEQ ID NO.1, and its encoding gene... FIP-SS14b The nucleotide sequence corresponds to SEQ ID NO.2. Through... E. coli The expression system expresses the FIP-SS14b gene encoding the protein of Phellinus linteus from the mulberry tree. FIP-SS14b The resulting recombinant protein can promote the proliferation of mouse macrophages RAW264.7, enhance their phagocytic activity, and regulate cytokine expression, thus possessing pharmaceutical development value. This invention utilizes heterologous gene expression technology to achieve the recombinant preparation of *Sanghuang* immunomodulatory protein, providing technical support and data for the subsequent industrial development of this protein.

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