一种植入型氰基丙烯酸酯医用胶制备方法及其应用

By employing low-temperature supercritical gradient extraction, molecular imprinting adsorption, and membrane separation technologies, combined with byproduct resource-based modification, the problems of high-temperature polymerization and incomplete impurity removal in the purification of existing cyanoacrylate medical adhesives have been solved. This has resulted in the preparation of a high-purity, low-residue, and biocompatible medical adhesive suitable for implantable surgical procedures and in vivo wound repair.

CN122146198BActive Publication Date: 2026-07-17ENOVE PRECISION PLASTICS CATHETER

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ENOVE PRECISION PLASTICS CATHETER
Filing Date
2026-05-07
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing purification processes for cyanoacrylate medical adhesives often result in high-temperature polymerization of monomers, poor selectivity in impurity removal, excessive solvent residue, substandard biocompatibility, waste of byproducts, and poor batch stability, making it difficult to meet implant-grade purity and safety requirements.

Method used

By employing low-temperature supercritical gradient extraction, molecularly imprinted selective adsorption, and membrane separation technologies, combined with byproduct resource utilization modification, multi-stage purification and stabilization continuous operation is achieved to prepare high-purity, low-residue, and biocompatible medical adhesives.

Benefits of technology

The preparation of high-purity cyanoacrylate medical adhesive has been achieved, avoiding the risks of high-temperature polymerization, improving biocompatibility and stability, reducing environmental pollution, lowering production costs, and making it suitable for implant-grade use.

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Abstract

本发明公开了一种植入型氰基丙烯酸酯医用胶制备方法及其应用,属于医用高分子材料纯化技术领域,旨在解决现有氰基丙烯酸酯医用胶纯化工艺中高温易引发单体聚合、杂质去除选择性差、溶剂残留超标、生物相容性不达标、副产物浪费、批次稳定性差、植入级纯度难以实现的技术问题,该方法包括:低温超临界梯度萃取、选择性吸附精制、膜分离除杂、副产物资源化改性、成品制备。本发明全程采用低于40℃的低温纯化工艺,摒弃传统高温蒸馏、重结晶工艺,从根源上避免氰基丙烯酸酯单体受热自聚,保证成品有效单体含量稳定,固化性能均匀,解决了现有工艺高温破坏单体稳定性的难题,杜绝高温聚合风险,医用胶稳定性大幅提升。
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