QTL candidate gene determination method based on linkage disequilibrium blocks and structural variations
By integrating linkage disequilibrium blocks and structural variations, a statistical model was constructed and candidate genes were screened. This solved the problem that the synergistic effects of genetic variations and the functional effects of structural variations were not integrated in the genetic analysis of existing technologies, and enabled fine analysis of quantitative traits and accurate identification of candidate genes.
CN122157764APending Publication Date: 2026-06-05INST OF GENETICS & DEVELOPMENTAL BIOLOGY CHINESE ACAD OF SCI
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- INST OF GENETICS & DEVELOPMENTAL BIOLOGY CHINESE ACAD OF SCI
- Filing Date
- 2026-02-26
- Publication Date
- 2026-06-05
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Figure CN122157764A_ABST
Abstract
The application discloses a QTL candidate gene determination method based on linkage disequilibrium blocks and structural variations, which comprises the following steps: S1, initial data import: preparing a QTL interval range obtained through preliminary positioning, and importing whole genome resequencing or chip data of a mapping population; S2, interval LD calculation: calculating linkage disequilibrium between all SNP sites in the QTL interval, and determining LD blocks: according to the calculated LD values, the strongly linked sites are divided into different LD Blocks; S3, haplotype typing: in each determined LD Block, the haplotype is classified according to the combination of SNPs, and the population is divided into different haplotype groups; S4, constructing a general linear model; S5, phenotype effect value and epistasis; S6, integrating SV and annotation data; and S7, generating a candidate gene priority set.
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