A dynamic sweat collection and detection device with anti-backflow and temperature compensation functions

Abstract

The application discloses a dynamic sweat collection and detection device with anti-backflow and temperature compensation functions, which comprises a sweat collection array inlet, a sweat transmission channel, an in-situ sweat filter sponge, a sweat collection and detection chamber, a multi-channel substance detection electrochemical electrode, a waste liquid collection area, a waste liquid discharge channel, a waste liquid absorption sponge, a temperature sensor placement area, a sweat flow channel and a sweat anti-backflow device. Sweat enters the device through the collection array inlet, is filtered and collected in the detection chamber, and is in contact with the multi-channel electrochemical electrode to complete detection. The detected sweat is discharged through the flow channel and the waste liquid discharge channel, and is absorbed by the waste liquid absorption sponge. The sweat anti-backflow device is used for inhibiting reverse flow and reducing the mixing of new and old sweat. The temperature sensor is used for temperature monitoring and signal compensation during detection. The application can realize continuous sweat collection, filtration, detection, discharge and temperature compensation, and improves the stability and accuracy of dynamic sweat detection.

Description

Technical Field

[0001] This invention belongs to the field of wearable biosensors and microfluidic detection technology, specifically relating to a dynamic sweat collection and detection device with anti-backflow and temperature compensation functions, which can be used for continuous collection, dynamic transmission, electrochemical detection and temperature compensation analysis of human sweat. Background Technology

[0002] Sweat contains various chemical components related to human physiological states, such as glucose, lactic acid, uric acid, sodium ions, potassium ions, chloride ions, pH value, and conductivity. Detecting sweat can provide reference information for human metabolic status, exercise status, dehydration status, and health monitoring. Compared with blood tests, sweat testing has advantages such as being non-invasive, convenient, and suitable for continuous monitoring, thus having high application value in the field of wearable health monitoring.

[0003] Existing sweat detection devices typically include a sweat collection structure and electrochemical detection electrodes, but they still have some shortcomings. First, sweat is prone to stagnation within the collection chamber, leading to mixing of new and old sweat and affecting the real-time nature of dynamic detection results. Second, backflow of sweat may occur within the microchannels, causing detected or discarded sweat to re-enter the detection area, thus reducing detection accuracy. Third, sweat detection signals are easily affected by temperature changes, especially during human movement, changes in ambient temperature, or prolonged wear; temperature drift can affect the stability of electrochemical detection results. Furthermore, sweat may contain impurities such as particulate matter, dander, or oil from the skin surface, which can easily contaminate the detection electrodes and affect the long-term reliability of the device. Therefore, it is necessary to design a sweat collection and detection device capable of dynamic sweat collection, in-situ filtration, continuous detection, backflow prevention, waste liquid discharge, and temperature compensation to improve the stability, accuracy, and continuous monitoring capabilities of sweat detection. Summary of the Invention

[0004] 1. This invention provides a dynamic sweat collection and detection device with anti-backflow and temperature compensation functions, which solves the problems of sweat retention, mixing of new and old sweat, backflow of waste liquid, temperature change affecting detection signal, and skin impurities contaminating detection electrodes in existing sweat detection devices, thereby improving the accuracy, stability and continuity of dynamic sweat detection.

[0005] 2. The device of the present invention includes a sweat collection array inlet (1), a sweat transmission channel (2), an in-situ sweat filtering sponge (3), a sweat collection and detection chamber (4), a multi-channel substance detection electrochemical electrode (5), a waste liquid collection area (6), a waste liquid discharge channel (7), a waste liquid absorption sponge (8), a temperature sensor placement area (9), a sweat flow channel (10), and a sweat anti-backflow device (11). The various structures cooperate with each other to realize the collection, filtration, detection, flow, discharge, and temperature compensation of sweat.

[0006] 3. The sweat collection array inlet (1) is used to contact the human skin surface and collect sweat. The sweat collection array inlet (1) includes multiple collection holes spaced apart. The multiple collection holes can be arranged circumferentially around the sweat collection and detection chamber (4) to increase the sweat collection area and improve the sweat collection efficiency under low sweat conditions.

[0007] 4. The sweat transmission channel (2) is connected to the sweat collection array inlet (1) and is used to guide the sweat collected by multiple collection holes into the sweat collection and detection chamber (4), and guide the sweat to flow in a preset direction through the channel structure, thereby improving the stability of sweat transport.

[0008] 5. The in-situ sweat filter sponge (3) is set on the sweat collection path to perform preliminary filtration of the sweat entering the device, reducing the entry of skin flakes, particles, oil or other impurities into the sweat collection and detection chamber (4), and at the same time can temporarily store and uniformly guide the sweat.

[0009] 6. The sweat collection and detection chamber (4) is used to collect the filtered and transmitted sweat and provide detection space for the multi-channel substance detection electrochemical electrode (5), so that the sweat can fully contact the electrode detection area and improve the stability and repeatability of the detection signal.

[0010] 7. The multi-channel substance detection electrochemical electrode (5) is set in correspondence with the sweat collection and detection chamber (4). The multi-channel substance detection electrochemical electrode (5) includes at least two detection channels, which can be used to detect one or more of glucose, lactic acid, uric acid, sodium ions, potassium ions, chloride ions, pH value or conductivity in sweat, so as to realize the synchronous detection of multiple parameters of sweat.

[0011] 8. The waste liquid collection area (6) is connected to the sweat flow channel (10) and the waste liquid discharge channel (7) to receive the sweat after testing; the waste liquid discharge channel (7) is used to guide the sweat in the waste liquid collection area (6) to the waste liquid absorption sponge (8) so as to realize the discharge of the sweat after testing.

[0012] 9. The waste liquid absorption sponge (8) is set at the end of the waste liquid discharge channel (7) to absorb the sweat after detection through capillary adsorption and to guide the sweat to flow continuously in the sweat flow channel (10) and the waste liquid discharge channel (7), so that the sweat sample in the sweat collection and detection chamber (4) can be continuously updated, reducing the detection error caused by sweat retention.

[0013] 10. The temperature sensor placement area (9) is located near the sweat flow channel (10) for arranging the temperature sensor. The temperature sensor is used to collect the temperature signal near the sweat detection area and to perform temperature compensation on the detection result of the multi-channel substance detection electrochemical electrode (5) based on the temperature signal, so as to reduce the impact of temperature fluctuation on the detection accuracy.

[0014] 11. The sweat flow channel (10) is used to connect the sweat collection and detection chamber (4), the waste liquid collection area (6) and the waste liquid discharge channel (7) to form a continuous dynamic sweat transport path; the sweat anti-backflow device (11) is set in the sweat flow channel (10). The sweat anti-backflow device (11) can adopt one or more of the following: asymmetric expansion-contraction structure, step-type flow restriction structure, bend-type flow guide structure or Tesla valve-like structure, to increase the resistance of reverse sweat flow, suppress the backflow of detected sweat or waste liquid towards the sweat collection and detection chamber (4), reduce the mixing of new and old sweat, and improve the real-time performance and reliability of dynamic sweat detection. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the overall structure of the dynamic sweat collection and detection device of the present invention.

[0016] Figure 2 This is a schematic diagram of the sweat flow channel, anti-backflow device, and temperature sensor placement area of ​​the present invention.

[0017] Explanation of reference numerals in the attached figures: (1) Sweat collection array inlet; (2) Sweat transmission channel; (3) In-situ sweat filter sponge; (4) Sweat collection and detection chamber; (5) Multi-channel substance detection electrochemical electrode; (6) Waste liquid collection area; (7) Waste liquid discharge channel; (8) Waste liquid absorption sponge; (9) Temperature sensor placement area; (10) Sweat flow channel; (11) Sweat anti-backflow device. Detailed Implementation

[0018] 1. Design and Composition of the Overall Structure of the Device. This embodiment provides a dynamic sweat collection and detection device with anti-backflow and temperature compensation functions. The device adopts a layered microfluidic structure design, including a skin-adhering collection layer, a sweat guiding layer, an electrochemical detection layer, a waste liquid discharge layer, and an encapsulation and protection layer. The device as a whole is a flexible sheet or semi-flexible sheet structure that can be attached to the surface of human skin to realize continuous collection, dynamic transmission, filtration, detection, waste liquid discharge, and temperature compensation of sweat. As shown in the attached figure, the device mainly includes a sweat collection array inlet (1), a sweat transmission channel (2), an in-situ sweat filtering sponge (3), a sweat collection and detection chamber (4), a multi-channel substance detection electrochemical electrode (5), a waste liquid collection area (6), a waste liquid discharge channel (7), a waste liquid absorption sponge (8), a temperature sensor placement area (9), a sweat flow channel (10), and a sweat anti-backflow device (11). Among them, the sweat collection array inlet (1) is used to collect sweat from the skin surface, the sweat transmission channel (2) is used to guide the sweat into the detection area, the in-situ sweat filter sponge (3) is used to perform preliminary filtration and uniform distribution of sweat, the sweat collection and detection chamber (4) is used to temporarily store and provide detection space, the multi-channel substance detection electrochemical electrode (5) is used to detect the target components in the sweat, the waste liquid collection area (6), the waste liquid discharge channel (7) and the waste liquid absorption sponge (8) are used to discharge the sweat after detection, the temperature sensor placement area (9) is used to arrange the temperature sensor, the sweat flow channel (10) is used to form a continuous flow path, and the sweat anti-backflow device (11) is used to suppress the reverse flow of sweat.

[0019] 2. Preparation of Device Materials and Processing Methods. In this embodiment, the main body layer of the device can be prepared using polydimethylsiloxane, polyimide, polyethylene terephthalate, thermoplastic polyurethane, medical silicone, double-sided medical adhesive film, or other biocompatible flexible materials. For layer structures that need to maintain a certain supporting strength, sheet-like polycarbonate, polymethyl methacrylate, or flexible printed circuit board materials can also be used. The sweat transmission channel (2), sweat flow channel (10), waste liquid discharge channel (7), and sweat anti-backflow device (11) in the sweat diversion layer can be formed by laser cutting, mold imprinting, soft lithography, 3D printing, mechanical engraving, or thin film layering and cutting. For laboratory prototypes, laser cutting of double-sided adhesive film or polyimide film can be preferred to prepare the microchannel structure; for subsequent batch production, mold imprinting or injection molding can be used. The multi-channel material detection electrochemical electrode (5) can be prepared by screen printing, inkjet printing, magnetron sputtering, vapor deposition, laser-induced graphene, or flexible circuit board processing methods. The electrode material can be carbon paste, gold, platinum, silver / silver chloride, graphene, carbon nanotubes, conductive polymers, or their composite materials. The temperature sensor can be a serpentine metal resistor, a thermistor, or a flexible resistive temperature sensing unit, which is located within the temperature sensor placement area (9).

[0020] 3. Structural Design of the Sweat Collection Array Inlet. The sweat collection array inlet (1) is located on the skin-contact side of the device and is used to contact the human skin surface and collect sweat. In this embodiment, the sweat collection array inlet (1) consists of multiple circular, elliptical, or near-circular collection holes, which are arranged in a circumferential array around the sweat collection and detection chamber (4). This array-type inlet structure can expand the skin contact collection area, allowing sweat secreted by sweat glands in different locations to enter the device. Compared with a single inlet structure, the multi-point array inlet can improve the collection efficiency under low sweat volume conditions and reduce the sampling instability caused by uneven distribution of local sweat glands. Multiple collection holes can be connected to the sweat collection and detection chamber (4) through the sweat transmission channel (2), allowing sweat to enter from different inlets and then converge into the detection chamber. The number, diameter, and distribution radius of the collection holes can be adjusted according to the wearing location, sweat secretion volume, and device size.

[0021] 4. Design and guiding function of the sweat transmission channel. The sweat transmission channel (2) is connected to the sweat collection array inlet (1) and is used to guide sweat from each collection inlet to the sweat collection and detection chamber (4). In this embodiment, the sweat transmission channel (2) is arranged in a radial or branched structure, which can concentrate the sweat collected from multiple inlets to the central detection area. The width and depth of the sweat transmission channel (2) can be designed according to the sweat flow requirements. If the channel size is too small, the sweat flow resistance may be too large, affecting the collection under low sweat conditions; if the channel size is too large, the dead volume may be increased, resulting in a decrease in the sweat renewal rate. Therefore, the sweat transmission channel (2) preferably adopts a small volume, short path, and low resistance structure to reduce the residence time of sweat before entering the detection chamber.

[0022] 5. Setting and function of in-situ sweat filter sponge. The in-situ sweat filter sponge (3) is set between the sweat collection array inlet (1) and the sweat collection and detection chamber (4), or in the inlet area of ​​the sweat collection and detection chamber (4). The in-situ sweat filter sponge (3) can be made of hydrophilic porous sponge, fiber membrane, non-woven fabric, polyurethane sponge, cellulose membrane or hydrogel porous material. The main functions of the in-situ sweat filter sponge (3) include: first, to initially intercept dander, dust, microparticles or skin surface oil in sweat, reducing impurities from directly entering the detection area; second, to temporarily store and buffer sweat through the porous structure, reducing the impact of instantaneous sweat flow fluctuations on the detection signal; third, to make the sweat more evenly distributed before entering the sweat collection and detection chamber (4), improving the wetting consistency of the electrode contact area. In a preferred embodiment, the in-situ sweat filter sponge (3) can be hydrophilically treated so that it can absorb sweat in a short time and guide the sweat to the sweat collection and detection chamber (4). The thickness and pore size of the in-situ sweat filter sponge (3) can be adjusted according to the sweat flow rate and filtration requirements, so as to ensure the filtration effect and avoid causing significant obstruction to the dynamic flow of sweat.

[0023] 6. Formation of the sweat collection and detection chamber. The sweat collection and detection chamber (4) is located at the end of the sweat transmission channel (2) and is the main space for sweat detection. In this embodiment, the sweat collection and detection chamber (4) is designed as a circular, elliptical or near-circular cavity structure, with a multi-channel substance detection electrochemical electrode (5) correspondingly arranged above or below it, so that the sweat entering the chamber can fully contact the electrode surface. The volume of the sweat collection and detection chamber (4) should not be too large to avoid sweat retention and response delay; at the same time, it should not be too small to avoid the sweat not being able to fully cover the electrode detection area. Preferably, the sweat collection and detection chamber (4) is designed as a thin-layer detection chamber, so that the sweat covers the electrode surface with a small volume and can be continuously renewed under the traction of the subsequent sweat flow channel (10) and waste liquid absorption sponge (8).

[0024] 7. Preparation and Functionalization of Multichannel Electrochemical Electrode for Substance Detection. A multichannel electrochemical electrode (5) for substance detection is disposed on the electrochemical detection layer and corresponds to the sweat collection and detection chamber (4). This electrode may include multiple working electrodes, a reference electrode, a counter electrode, and connecting leads. Multiple detection channels can be used to detect different target substances in sweat, such as glucose, lactic acid, uric acid, pH value, sodium ions, potassium ions, chloride ions, conductivity, etc. In this embodiment, the multichannel electrochemical electrode (5) for substance detection can be prepared using a flexible substrate. The working electrode can be a carbon electrode, a gold electrode, a platinum electrode, or a conductive carbon material composite electrode; the reference electrode can be an Ag / AgCl electrode; and the counter electrode can be a carbon electrode, a platinum electrode, or a gold electrode. If used for glucose or lactic acid detection, a corresponding oxidase and protective film can be modified on the surface of the working electrode; if used for ion detection, an ion-selective film can be modified on the electrode surface; if used for pH detection, polyaniline, iridium oxide, or other pH-sensitive materials can be used for modification. The electrode leads extend to the end of the device via flexible wiring, connecting to an external electrochemical testing instrument, a miniature acquisition module, or a wearable wireless readout module. To prevent sweat from interfering with the connection, the electrode leads, except for the detection sites, can be covered with an insulating protective layer, exposing only the sensitive electrode surface in the detection area.

[0025] 8. Temperature sensor placement area and temperature compensation method. The temperature sensor placement area (9) is located near the sweat flow channel (10), preferably close to the sweat collection and detection chamber (4) and the multi-channel substance detection electrochemical electrode (5), for real-time acquisition of temperature information near the detection area. In this embodiment, the temperature sensor can be a serpentine metal resistance temperature sensor, a thermistor temperature sensor, or a flexible temperature sensor. The temperature sensor can be located on the same flexible substrate as the electrochemical electrode, or it can be located in a separate temperature detection channel. If the temperature sensor is used to measure sweat temperature, its sensitive area should be as close as possible to the sweat flow channel (10) or in thermal contact with sweat; if it is used to measure skin surface temperature, its sensitive area can be closer to the skin side. During the detection process, the temperature sensor collects temperature signals and uses the temperature information to compensate for the electrochemical detection signal. For example, when temperature changes cause changes in the enzyme reaction rate or electrode response current, the detection results can be corrected according to the pre-established temperature correction curve, thereby improving the detection accuracy under different ambient temperatures and different wearing conditions.

[0026] 9. Continuous transport design of the sweat flow channel. The sweat flow channel (10) is used to connect the sweat collection and detection chamber (4), the waste liquid collection area (6), and the waste liquid discharge channel (7) to form a complete dynamic transport path for sweat. In this embodiment, the sweat flow channel (10) can be designed as a long strip, serpentine, or straight channel, with one end connected to the sweat collection and detection chamber (4) and the other end connected to the waste liquid collection area (6) or the waste liquid discharge channel (7). The sweat flow channel (10) enables the sweat after detection to be discharged from the detection area in a timely manner, thereby avoiding the long-term retention of old sweat. For dynamic sweat detection, the sweat flow channel (10) can enable the sweat sample to form a continuous flow process of "collection-detection-discharge", improving the response speed of the detection results to the real-time sweating state of the human body. In a preferred embodiment, the sweat flow channel (10) can be hydrophilized or have microstructures set on the inner wall of the channel to enhance the capillary drive capability. The depth and width of the sweat flow channel (10) can be adjusted according to the target sweat flow rate to achieve a balance between detection stability and sample update speed.

[0027] 10. Structure and working principle of the sweat backflow prevention device. The sweat backflow prevention device (11) is installed in the sweat flow channel (10) to suppress the backflow of sweat or waste liquid after detection towards the sweat collection and detection chamber (4). In this embodiment, the sweat backflow prevention device (11) can adopt an asymmetric expansion-contraction structure, a stepped flow restriction structure, a bent flow guiding structure, a Tesla-like valve structure, or a combination of the above structures. Taking the asymmetric expansion-contraction structure as an example, when sweat flows from the sweat collection and detection chamber (4) to the waste liquid collection area (6) in the normal direction, the fluid can pass through the structure relatively smoothly with low flow resistance; when the sweat is squeezed, changes its posture, or is disturbed by external factors and has a reverse flow tendency, the sweat will encounter local contraction, expansion, or bending at the structure, resulting in greater local flow resistance, streamline deflection, flow dissipation, or capillary pressure resistance, thereby reducing the reverse flow speed. The sweat backflow prevention device (11) is a passive anti-backflow structure that does not require external drive or mechanical moving parts. Its simple structure makes it suitable for integration with flexible microfluidic devices. Its function is not to completely close the channel, but to increase the reverse flow resistance, reduce the possibility of waste liquid backflow and mixing of new and old sweat, thereby improving the real-time performance and stability of dynamic sweat detection.

[0028] 11. Setting of waste liquid collection area, waste liquid discharge channel and waste liquid absorption sponge. The waste liquid collection area (6) is set downstream of the sweat flow channel (10) and is used to temporarily store the sweat that has been tested. The waste liquid discharge channel (7) is connected to the waste liquid collection area (6) and is used to further guide the waste liquid to the end of the device. The waste liquid absorption sponge (8) is set at the end of the waste liquid discharge channel (7) and is used to absorb the sweat after testing. The waste liquid absorption sponge (8) can be made of hydrophilic absorbent sponge, fiber cotton, non-woven fabric, absorbent gel or other materials with capillary adsorption capacity. During use, the waste liquid absorption sponge (8) continuously absorbs the sweat at the end of the channel, forming a capillary traction force from the inlet to the outlet inside the device, thereby promoting the continuous flow of sweat. Through the cooperation of the waste liquid collection area (6), the waste liquid discharge channel (7) and the waste liquid absorption sponge (8), the device can discharge the sweat after testing in a timely manner and avoid the sweat from staying in the testing chamber for a long time. This structure helps improve the efficiency of sweat sample renewal and ensures that the sweat in the detection area is closer to the current secretion state of the human body.

[0029] 12. Device Stacking Assembly Process. In this embodiment, the device can be assembled according to the following steps. First, a skin-adhesive collection layer is prepared, and a sweat collection array inlet (1) is processed on this layer. A medical adhesive layer is set on the skin-adhesive side as needed. Second, a sweat guiding layer is prepared, and a sweat transmission channel (2), a sweat flow channel (10), a waste liquid discharge channel (7), and a sweat anti-backflow device (11) are processed on this layer. Then, an in-situ sweat filter sponge (3) is placed at a predetermined position between the sweat collection array inlet (1) and the sweat collection and detection chamber (4), and a waste liquid absorption sponge (8) is placed at the end of the waste liquid discharge channel (7). After that, the flexible electrode layer containing the multi-channel substance detection electrochemical electrode (5) is aligned with the sweat collection and detection chamber (4) so ​​that the electrode detection site coincides with the position of the chamber. Then, a temperature sensor is set in the temperature sensor placement area (9), and it is ensured that it has a good thermal coupling relationship with the sweat detection area. Finally, a protective encapsulation layer is placed over the device, and the entire device is encapsulated using hot pressing, bonding, plasma bonding, or mechanical pressing. After encapsulation, it should be ensured that the channels are not crushed, and that the sweat collection inlet, detection chamber, and waste liquid discharge path remain connected.

[0030] 13. Pretreatment before use. Before use, the sweat transmission channel (2), sweat flow channel (10), and sweat collection and detection chamber (4) of the device can be pretreated with hydrophilicity to improve the stability of sweat entry and flow. Pretreatment methods may include ultraviolet ozone treatment, plasma treatment, hydrophilic coating treatment, or pre-wetting with PBS buffer. For the multi-channel substance detection electrochemical electrode (5), electrochemical activation or baseline calibration can be performed before use. If detecting enzymatic reaction indicators such as glucose and lactic acid, appropriate storage conditions and pre-wetting time should be selected according to the stability of the sensing membrane material. If detecting ion concentration or pH value, a calibration curve can be established using a standard solution. The temperature sensor can be calibrated by a constant temperature platform or a standard thermometer before use to obtain the correspondence between the resistance value or output signal and temperature. The temperature calibration result can be used for temperature compensation of the subsequent sweat detection signal.

[0031] 14. Dynamic Sweat Collection and Detection Process. During use, the device is attached to the sweating area of ​​the body, such as the forearm, upper arm, forehead, back, or chest. After attachment, sweat secreted by the skin enters the device through the sweat collection array inlet (1). After passing through the in-situ sweat filter sponge (3), the sweat enters the sweat transmission channel (2) and collects in the sweat collection and detection chamber (4). When the sweat in the sweat collection and detection chamber (4) covers the multi-channel substance detection electrochemical electrode (5), the electrode begins to detect the target components in the sweat. Detection methods can include open-circuit potential method, amperometric method, cyclic voltammetry, differential pulse voltammetry, electrochemical impedance spectroscopy, or conductivity detection method. The specific detection method is determined based on the target substance and electrode modification material. After detection, the sweat, under the continuous entry of subsequent sweat and the capillary adsorption and traction of the waste liquid absorption sponge (8), enters the waste liquid collection area (6) along the sweat flow channel (10), and then reaches the waste liquid absorption sponge (8) through the waste liquid discharge channel (7). During this process, the sweat anti-backflow device (11) suppresses the backflow of sweat in the direction of waste liquid, and the temperature sensor simultaneously collects the temperature signal near the detection area and uses it for detection result compensation.

Claims

1. A dynamic sweat collection and detection device with anti-backflow and temperature compensation functions, characterized in that: The system includes a sweat collection array inlet (1), a sweat transmission channel (2), an in-situ sweat filter sponge (3), a sweat collection and detection chamber (4), a multi-channel substance detection electrochemical electrode (5), a waste liquid collection area (6), a waste liquid discharge channel (7), a waste liquid absorption sponge (8), a temperature sensor placement area (9), a sweat flow channel (10), and a sweat anti-backflow device (11). The sweat collection array inlet (1) is used to contact the surface of human skin and collect sweat. The sweat transmission channel (2) is connected to the sweat collection array inlet (1) and is used to guide the collected sweat into the sweat collection and detection chamber (4). The in-situ sweat filter sponge (3) is equipped with... Placed on the sweat collection path, it is used to filter impurities in the sweat; the sweat collection and detection chamber (4) is correspondingly set with the multi-channel substance detection electrochemical electrode (5) to realize the detection of sweat components; the sweat flow channel (10) is connected to the sweat collection and detection chamber (4) and connected to the waste liquid collection area (6) and the waste liquid discharge channel (7); the waste liquid absorption sponge (8) is set at the end of the waste liquid discharge channel (7) to absorb the sweat after detection; the temperature sensor placement area (9) is used to install the temperature sensor; the sweat anti-backflow device (11) is set in the sweat flow channel (10) to suppress the reverse flow of sweat.

2. The dynamic sweat collection and detection device with anti-backflow and temperature compensation functions according to claim 1, characterized in that: The sweat collection array inlet (1) includes multiple spaced collection holes arranged around the sweat collection and detection chamber (4) to increase the skin contact collection area and improve the sweat collection efficiency under low sweat conditions.

3. The dynamic sweat collection and detection device with anti-backflow and temperature compensation functions according to claim 1, characterized in that: The in-situ sweat filter sponge (3) is located between the sweat collection array inlet (1) and the sweat collection and detection chamber (4) to intercept particulate matter, dander or other impurities on the skin surface, and to temporarily store and uniformly guide sweat through its porous structure.

4. The dynamic sweat collection and detection device with anti-backflow and temperature compensation functions according to claim 1, characterized in that: The multi-channel substance detection electrochemical electrode (5) includes at least two detection channels for detecting one or more target substances in sweat, including one or more of glucose, lactic acid, uric acid, sodium ions, potassium ions, chloride ions, pH value, or conductivity.

5. A dynamic sweat collection and detection device with anti-backflow and temperature compensation functions according to claim 1, characterized in that: The temperature sensor placement area (9) is located near the sweat flow channel (10) and is used to arrange the temperature sensor. The temperature sensor is used to collect the temperature signal near the sweat detection area and to perform temperature compensation on the detection signal of the multi-channel substance detection electrochemical electrode (5).

6. The dynamic sweat collection and detection device with anti-backflow and temperature compensation functions according to claim 1, characterized in that: The sweat backflow prevention device (11) is one or more of the following structures installed in the sweat flow channel (10): asymmetric expansion-contraction structure, step-type flow restriction structure, bend-type flow guide structure or Tesla valve-like structure. It is used to increase the resistance to reverse flow of sweat and reduce the possibility of sweat flowing back from the waste liquid discharge channel (7) to the sweat collection and detection chamber (4).

7. The dynamic sweat collection and detection device with anti-backflow and temperature compensation functions according to claim 1, characterized in that: The waste liquid collection area (6) is connected to the waste liquid discharge channel (7). The waste liquid absorption sponge (8) is set at the end of the waste liquid discharge channel (7). Through capillary adsorption, the sweat after detection is pulled to flow, so that the sweat in the sweat collection and detection chamber (4) can be continuously renewed.

8. The dynamic sweat collection and detection device with anti-backflow and temperature compensation functions according to claim 1, characterized in that: The dynamic sweat collection and detection device has a layered structure, including a skin-contact collection layer, a sweat diversion layer, an electrochemical detection layer, and an encapsulation and protection layer. The skin-contact collection layer is used for contact with human skin, the sweat diversion layer is used for sweat transmission, filtration, backflow prevention, and waste discharge, the electrochemical detection layer is used for sweat composition detection and temperature detection, and the encapsulation and protection layer is used for fixing and protecting the device.

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