Use of creatine in the preparation of a formulation against viruses of aquatic animals

By supplementing creatine or its precursors to increase intracellular creatine levels, an antiviral agent for aquatic animals was developed, solving the problem of the lack of effective prevention and control of NNV, TFV and MsRV in existing technologies, and achieving significant inhibition of viral proliferation and reduction of mortality.

CN122163590APending Publication Date: 2026-06-09SUN YAT SEN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUN YAT SEN UNIV
Filing Date
2024-12-09
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

The lack of effective antiviral agents for aquatic animals, especially against neural necrosis virus (NNV), tiger frog virus (TFV), and largemouth bass rhabdovirus (MsRV), has led to high mortality rates and difficulties in prevention and control in the aquaculture industry.

Method used

By supplementing creatine or its precursors such as guanidinoacetic acid and L-arginine, the intracellular creatine content is increased, which significantly inhibits viral proliferation, thus creating an antiviral agent for aquatic animals to prevent and treat viral diseases.

Benefits of technology

It significantly reduced virus proliferation and infection rates, lowered the mortality rate of NNV-infected fish, avoided the operational difficulties and stress on juvenile fish caused by vaccination, and promoted the healthy development of aquaculture.

✦ Generated by Eureka AI based on patent content.

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Abstract

This invention discloses the application of creatine in the preparation of formulations against aquatic animal viruses. The invention discovers that by supplementing with creatine precursors or creatine itself to increase intracellular creatine levels, the proliferation of aquatic animal viruses, such as neural necrosis virus (NNV), tiger frog virus (TFV), and largemouth bass rhabdovirus (MsRV), can be significantly inhibited. Creatine, creatine precursors, or other substances that can increase creatine levels in the body can be used to formulate formulations against these aquatic animal viruses. Furthermore, creatine supplementation can significantly reduce the mortality rate of fish infected with NNV, meaning that creatine supplementation can prevent and treat viral diseases caused by viral infections. Therefore, substances that can increase creatine levels in the body can also be used to formulate drugs for the prevention and treatment of viral diseases caused by aquatic animal virus infections. This invention is beneficial to the prevention and treatment of viral diseases caused by aquatic animal virus infections and the healthy development of aquaculture.
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