An external plaster for treating herpes zoster and a preparation method thereof

Abstract

The present application relates to the technical field of traditional Chinese medicine preparation, in particular to a kind of external plaster for treating herpes zoster and preparation method thereof.The plaster comprises the following raw materials by weight: 16-20 parts of Gastrodia elata, 8-12 parts of Cimicifuga foetida, 1.5-4.5 parts of Scorpio, 1.5-4.5 parts of Solpugid, 4-8 parts of White Muscae, 4-8 parts of Earthworm, 4-8 parts of Periostracum Cicadae, 1.5-4.5 parts of Ophiopogon, 1.5-4.5 parts of Manis pentadactyla, 0.5-1.5 parts of Borneolum Syntheticum, 160-300 parts of Camphorated Oil, and 40-80 parts of Yellow Dan.The external plaster for treating herpes zoster can effectively treat herpes zoster, has a high cure rate, and has no sequelae after cure, and has good detoxification and analgesic effects.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine preparation technology, and in particular to a topical ointment for treating herpes zoster and its preparation method. Background Technology

[0002] Shingles is an acute infectious disease of the skin and mucous membranes caused by the varicella-zoster virus. Clinically, it is characterized by sudden onset, a band-like distribution along a nerve, unilateral distribution, and dense clusters of blisters, with significant pain and very little recurrence after recovery. The disease is not highly contagious; shingles patients cannot directly transmit the varicella-zoster virus, but can cause outbreaks of chickenpox in susceptible populations. Its transmission route remains "skin-air-respiratory." Children infected clinically present with chickenpox, while adults present with shingles. Shingles infection accounts for approximately 10%-20% of adult cases, but is more common in the elderly and immunocompromised individuals. Local trauma, certain systemic diseases, acute and chronic infectious diseases, and poisoning are common precipitating factors.

[0003] Postherpetic neuralgia occurs because the varicella-zoster virus is neurotropic. After invading the sensory nerve endings in the skin, it can travel along the nerves to the ganglia of the dorsal root of the spinal cord and remain dormant there. When the host's cellular immune function is weakened, such as during a cold, fever, systemic lupus erythematosus, or malignant tumors, the virus is reactivated, causing inflammation and necrosis of the ganglia. Simultaneously, the reactivated virus can travel along peripheral nerve fibers back to the skin, causing blisters accompanied by pain. The older the patient, the more severe the postherpetic neuralgia. If the virus and the virus that has been transmitted to the peripheral nerves are cleared from the body, no sequelae will occur; otherwise, postherpetic neuralgia may develop.

[0004] First, existing treatments are not ideal and are prone to causing sequelae. Current technologies often use hormones and antibiotics to treat shingles, but these methods can easily damage liver and kidney function, weaken the body's immunity and self-healing abilities, and easily lead to postherpetic neuralgia. After recovery, changes in weather can easily trigger local nerve pain and itching. Second, existing traditional Chinese medicine preparations are not effective in relieving pain when treating shingles. Postherpetic neuralgia causes patients immense and persistent suffering, reducing their quality of life. Summary of the Invention

[0005] To address the aforementioned problems, this invention provides a topical ointment for treating shingles and its preparation method. This topical ointment for treating shingles can effectively treat shingles with a high cure rate, no sequelae after cure, and good detoxification and pain relief effects.

[0006] The technical solution adopted by this invention to solve its technical problem is as follows: This topical ointment for treating herpes zoster comprises the following raw materials in parts by weight: 16-20 parts of Gastrodia elata, 8-12 parts of Cimicifuga foetida, 1.5-4.5 parts of Buthus martensii, 1.5-4.5 parts of Scolopendra subspinipes, 4-8 parts of Bombyx mori, 4-8 parts of Pheretima aspergillum, 4-8 parts of Cicadae periostracum, 1.5-4.5 parts of Smilax china, 1.5-4.5 parts of Pangolin scales, 0.5-1.5 parts of Borneol, 160-300 parts of Sesame oil, and 40-80 parts of Litharge.

[0007] Preferably, the topical ointment for treating herpes zoster comprises the following raw materials in parts by weight: 17-19 parts of Gastrodia elata, 9-11 parts of Cimicifuga foetida, 2-4 parts of Buthus martensii, 2-4 parts of Scolopendra subspinipes, 5-7 parts of Bombyx mori, 5-7 parts of Pheretima aspergillum, 5-7 parts of Cicadae periostracum, 2-4 parts of Scabra slough, 2-4 parts of Pangolin scales, 0.8-1.2 parts of Borneol, 190-280 parts of Sesame oil, and 30-70 parts of Litharge.

[0008] Preferably, the topical ointment for treating herpes zoster comprises the following ingredients in parts by weight: 18 parts Gastrodia elata, 10 parts Cimicifuga foetida, 3 parts Scorpion, 3 parts Centipede, 6 parts Bombyx mori, 6 parts Earthworm, 6 parts Cicada slough, 3 parts Snake slough, 3 parts Pangolin scales, 1 part Borneol, 240 parts Sesame oil, and 60 parts Lithium styrax.

[0009] This topical ointment for treating shingles also includes the following ingredients in parts by weight: 4-6 parts frankincense and 5-7 parts myrrh.

[0010] This topical ointment for treating shingles also includes the following ingredients in parts by weight: 5 parts frankincense and 6 parts myrrh.

[0011] The preparation method of this topical ointment for treating herpes zoster includes the following steps: 1) Mix Gastrodia elata, Cimicifuga foetida, scorpion, centipede, white silkworm, earthworm, cicada slough, snake slough and pangolin according to the weight parts, add sesame oil, soak at room temperature for 6-8 days, then heat to extract the oil, filter out the herbs to obtain medicinal oil; 2) Heat the medicinal oil until it forms beads when dropped into water, add litharge to the medicinal oil, heat and mix until it forms a paste when dropped into water, pour it into water to soak, and obtain the plaster; 3) Remove the plaster from the water, let it dry, then heat it and spread it on a cotton cloth to obtain the plaster.

[0012] Preferably, the specific operation of heating the plaster in step 3) is as follows: heat and soften the plaster, apply 10g-20g of plaster to each 8 square centimeter area, and apply the plaster to a cotton cloth.

[0013] Gastrodia elata, sweet and neutral in nature. It enters the Liver meridian. Its functions and indications include calming the liver, extinguishing wind, and stopping spasms. It is used for headaches, dizziness, numbness of limbs, infantile convulsions, epileptic seizures, and tetanus.

[0014] Cimicifuga rhizome is pungent, slightly sweet, and slightly cold in nature. It enters the lung, spleen, stomach, and large intestine meridians. Its main functions are to release exterior pathogens and promote rash eruption, clear heat and detoxify, and raise yang qi. It is used for wind-heat headache, toothache, canker sores, sore throat, incomplete measles eruption, rashes caused by yang toxins; rectal prolapse, and uterine prolapse.

[0015] Whole scorpion, the dried body of the East Asian scorpion (Scorpionus spp.), a member of the family Scorpionidae. It is pungent and neutral in nature; poisonous, and enters the liver meridian. Its functions include calming wind and relieving spasms, attacking toxins and dispersing nodules, unblocking meridians and relieving pain. It is indicated for infantile convulsions, spasms, facial paralysis due to stroke, hemiplegia, tetanus, stubborn rheumatism, migraine, sores, and scrofula.

[0016] Centipede, pungent and warm in nature; poisonous. It enters the liver meridian. Main uses: calms wind and relieves spasms, dissipates toxins and nodules, unblocks meridians and relieves pain. Used for infantile convulsions, spasms, facial paralysis due to stroke, hemiplegia, tetanus, stubborn rheumatism, sores, scrofula, and snake bites.

[0017] White-stiff silkworm (Bombyx mori) is the dried whole larva of the silkworm moth (Bombyx mori) that dies after infection with Beauveria bassiana. It is salty, pungent, and neutral in nature. It enters the liver, lung, and stomach meridians. It dispels wind and calms convulsions, resolves phlegm and dissipates nodules. It is used for infantile convulsions, sore throat, itchy skin, submandibular lymphadenitis, and facial nerve paralysis.

[0018] Pangolin scales, the scales of a pangolin, are salty and slightly cold in nature. They enter the liver and stomach meridians and are used to treat blood stasis, dysmenorrhea, lactation, carbuncles, and boils. They are also used to treat amenorrhea due to blood stasis, rheumatic pain, insufficient lactation, carbuncles, and scrofula.

[0019] Earthworm, salty and cold in nature, enters the liver, spleen, and bladder meridians; its functions are to clear heat and calm the mind, unblock the meridians, relieve asthma, and promote urination; it is indicated for high fever with delirium, convulsions, joint pain, numbness of limbs, hemiplegia, cough and wheezing due to lung heat, oliguria and edema, and hypertension.

[0020] Cicada molts are the exoskeletons shed by the larvae of cicadas (Cicadaidae) during molting. They are sweet and cold in nature, and enter the lung and liver meridians. Their functions include dispelling wind and heat, relieving sore throat, promoting rash eruption, clearing away eye obstructions, relieving spasms, anti-allergy, alleviating chronic inflammation, and improving microcirculation.

[0021] Snake slough is the dried epidermal membrane shed by snakes of the Colubridae family, such as the black-browed rat snake, the rat snake, or the black-banded snake. It is salty, sweet, and neutral in nature. It enters the Liver meridian. Its functions and indications include dispelling wind, calming convulsions, detoxifying, and clearing away pterygium. It is used for infantile convulsions, spasms, pterygium, sore throat, boils, and itchy skin.

[0022] Borneol is bitter and slightly cold, and enters the heart, spleen, and lung meridians. Its functions are to open the orifices and awaken the mind, clear heat and relieve pain. It is indicated for febrile diseases with delirium and convulsions, stroke with phlegm syncope, qi stagnation and sudden syncope, coma due to sudden illness, red eyes, mouth sores, sore throat, and purulent discharge from the ear canal.

[0023] Sesame oil is a fatty oil obtained by pressing the mature seeds of *Sesamum indicum*, a plant in the family Gentianaceae. It is sweet and cool in nature. It moistens dryness, promotes bowel movements, detoxifies, and promotes tissue regeneration. It is used as a solvent, lubricant, and excipient. Externally, it is used as a base for ointments and plasters.

[0024] Lithium tetroxide, a form of lead oxide produced through lead processing, has a pungent and salty taste, and is slightly cold in nature. Its functions and indications include drawing out toxins, promoting tissue regeneration, and astringing sores. It is used to treat sores, boils, carbuncles, traumatic bleeding, and burns.

[0025] The applicant discovered that people who frequently stay up late, spend excessive time on their phones, and get angry are more prone to shingles. Those with liver qi stagnation, liver qi deficiency, liver qi stagnation, blood stasis, damp-heat in the liver and gallbladder, or disharmony between the liver and stomach are also at high risk for shingles. Through research, the applicant determined the causes of shingles to be: external pathogenic factors and internal emotional factors, irregular diet, unhealthy lifestyle, disharmony of qi and blood, organ dysfunction, accumulation of pathogenic toxins, generation of wind, dampness, phlegm, dryness, heat, and toxins, leading to deficiency and depression, and the generation of damp-heat toxins. Wind is considered the root of all diseases, and skin diseases are closely related to wind pathogens. When the body's defensive qi is weak, wind pathogens invade and obstruct the skin, preventing internal and external flow, leading to disharmony of the body's defensive and nutritive qi, poor blood circulation, malnourishment of the skin, and impaired excretion of damp-heat toxins, resulting in shingles. The applicant also discovered that shingles is related to the liver and spleen. Damp-heat in the spleen and liver meridians can cause herpes and easily lead to pain. Treatment should focus on calming the wind, clearing heat and detoxifying, and relieving pain.

[0026] The applicant, through research, determined the following components of this invention: Gastrodia elata, which can extinguish wind and stop spasms, dispel wind and unblock meridians, and calm the liver and subdue yang. Cimicifuga foetida, which can release exterior pathogens and promote rash eruption, and clear heat and detoxify. Gastrodia elata combined with Cimicifuga foetida can extinguish wind and stop spasms, detoxify and kill bacteria, enhance qi and blood, and expel toxins from the body to the surface. Scorpion and centipede used together can extinguish wind and stop spasms, attack toxins and dissipate nodules, reduce swelling and relieve pain, and their combined use has a synergistic effect. Cicada slough can disperse wind-heat, benefit the throat and promote rash eruption, and extinguish wind and stop spasms. Snake slough can dispel wind and relieve spasms, and detoxify and reduce swelling. Bombyx mori, which can extinguish wind and stop spasms, resolve phlegm and dissipate nodules, and reduce swelling and relieve pain. Cicada slough, snake slough, and Bombyx mori used together can extinguish wind and promote rash eruption, clear heat and detoxify, and reduce swelling and dissipate nodules. Cimicifuga foetida, cicada slough, and Bombyx mori used together can enhance the effects of releasing exterior pathogens and promoting rash eruption, clearing heat and detoxifying. Gastrodia elata combined with earthworm can calm the liver and extinguish wind, unblock meridians and relieve pain, and promote diuresis and reduce swelling. Pangolin scales invigorate blood circulation, promote menstruation, detoxify, and reduce swelling. Borneol can open the orifices and enhance the effects of clearing heat, detoxifying, reducing swelling, and relieving pain. Through the synergistic effect of the various ingredients in the formula of this invention, detoxification and dispersing of nodules are achieved, swelling and pain are reduced, and rashes are eliminated. The room temperature in step 1) is 25~30℃. Preferably, the heating method in step 2) is as follows: heat the medicinal oil to 200℃-230℃, stirring and heating until it forms beads when dripped; add litharge to the medicinal oil, heat to 250℃-270℃, stirring and heating until it forms a paste when dripped. The soaking time in water in step 2) is more than 3 days, preferably 3-5 days.

[0027] Compared with the prior art, the beneficial effects of the topical ointment for treating herpes zoster and its preparation method of the present invention are as follows: 1. This topical ointment for treating shingles can effectively treat shingles and postherpetic neuralgia with a high cure rate and no sequelae. The overall effective rate for treating shingles is 93%-98%, and the cure rate is 92%-95%. For postherpetic neuralgia, the effective rate is 99%-100%, and the cure rate is 79%-85%.

[0028] 2. This topical ointment for treating shingles has good detoxifying and analgesic effects. It can significantly relieve pain caused by shingles and localized neuralgia and itching caused by postherpetic neuralgia, improving the patient's quality of life. Pain is significantly relieved after 3-6 days of application, and patients can resume their daily lives.

[0029] 3. This topical ointment for treating shingles is fast-acting and requires a short treatment course. One application lasts for 7 days, and two applications are sufficient for a cure.

[0030] 4. The applicant found in the research that the topical ointment for treating herpes zoster can also treat breast nodules, benign lymphomas, and boils, and has good therapeutic effects. Detailed Implementation

[0031] Examples 1-5 are specific embodiments of a topical ointment for treating herpes zoster and its preparation method according to the present invention, wherein Example 1 is the best embodiment. Example

[0032] The formula of this embodiment includes the following ingredients in parts by weight: 18 parts of Gastrodia elata, 10 parts of Cimicifuga foetida, 3 parts of scorpion, 3 parts of centipede, 6 parts of silkworm pupae, 6 parts of earthworm, 6 parts of cicada molting, 3 parts of snake molting, 3 parts of pangolin scales, 1 part of borneol, 5 parts of frankincense, 6 parts of myrrh, 240 parts of sesame oil, and 60 parts of litharge. The preparation method includes the following steps: 1) Mix frankincense, myrrh, gastrodia elata, cimicifuga foetida, scorpion, centipede, silkworm, earthworm, cicada slough, snake slough and pangolin according to the weight parts, add sesame oil, soak at room temperature for 6-8 days, then heat to extract the oil, filter out the herbs to obtain medicinal oil; 2) Heat the medicinal oil to 200℃-230℃, stirring and heating until it forms beads when dripped into water. Add litharge to the medicinal oil, heat to 250℃-270℃, stirring and heating until it forms a paste when dripped into water. Pour it into water and soak for 3-5 days to obtain the plaster. 3) Remove the plaster from the water, let it dry, then heat it to soften it. Apply 10g-20g of plaster to each 8 square centimeter area on a cotton cloth. Example

[0033] The formula of this embodiment includes the following raw materials in parts by weight: 19 parts of Gastrodia elata, 9 parts of Cimicifuga foetida, 4 parts of scorpion, 2 parts of centipede, 7 parts of silkworm pupae, 5 parts of earthworm, 7 parts of cicada molting, 2 parts of snake molting, 4 parts of pangolin scales, 0.8 parts of borneol, 5 parts of frankincense, 6 parts of myrrh, 190 parts of sesame oil, and 35 parts of litharge. The preparation method includes the following steps: 1) Mix frankincense, myrrh, gastrodia elata, cimicifuga foetida, scorpion, centipede, silkworm, earthworm, cicada slough, snake slough, pangolin scales, frankincense and myrrh according to the weight, add sesame oil, soak at room temperature for 6-8 days, then heat to extract the oil, filter out the herbs to obtain medicinal oil; 2) Heat the medicinal oil to 200℃-230℃, stirring and heating until it forms beads when dripped into water. Add litharge to the medicinal oil, heat to 250℃-270℃, stirring and heating until it forms a paste when dripped into water. Pour it into water and soak for 3-5 days to obtain the plaster. 3) Remove the plaster from the water, let it dry, then heat it to soften it. Apply 10g-20g of plaster to each 8 square centimeter area on a cotton cloth. Example

[0034] The formula of this embodiment includes the following ingredients in parts by weight: 17 parts of Gastrodia elata, 11 parts of Cimicifuga foetida, 2 parts of scorpion, 4 parts of centipede, 5 parts of silkworm pupae, 7 parts of earthworm, 5 parts of cicada molting, 4 parts of snake molting, 2 parts of pangolin scales, 1.2 parts of borneol, 280 parts of sesame oil, and 70 parts of litharge. The preparation method includes the following steps: 1) Mix Gastrodia elata, Cimicifuga foetida, scorpion, centipede, white silkworm, earthworm, cicada slough, snake slough and pangolin according to the weight parts, add sesame oil, soak at room temperature for 6-8 days, then heat to extract the oil, filter out the herbs to obtain medicinal oil; 2) Heat the medicinal oil to 200℃-230℃, stirring and heating until it forms beads when dripped into water. Add litharge to the medicinal oil, heat to 250℃-270℃, stirring and heating until it forms a paste when dripped into water. Pour it into water and soak for 3-5 days to obtain the plaster. 3) Remove the plaster from the water, let it dry, then heat it to soften it. Apply 10g-20g of plaster to each 8 square centimeter area on a cotton cloth. Example

[0035] The formula of this embodiment includes the following ingredients in parts by weight: 20 parts of Gastrodia elata, 8 parts of Cimicifuga foetida, 4.5 parts of scorpion, 1.5 parts of centipede, 8 parts of silkworm pupae, 4 parts of earthworm, 8 parts of cicada molting, 1.5 parts of snake molting, 4.5 parts of pangolin scales, 0.5 parts of borneol, 300 parts of sesame oil, and 80 parts of litharge. The preparation method includes the following steps: 1) Mix Gastrodia elata, Cimicifuga foetida, scorpion, centipede, white silkworm, earthworm, cicada slough, snake slough and pangolin according to the weight parts, add sesame oil, soak at room temperature for 6-8 days, then heat to extract the oil, filter out the herbs to obtain medicinal oil; 2) Heat the medicinal oil to 200℃-230℃, stirring and heating until it forms beads when dripped into water. Add litharge to the medicinal oil, heat to 250℃-270℃, stirring and heating until it forms a paste when dripped into water. Pour it into water and soak for 3-5 days to obtain the plaster. 3) Remove the plaster from the water, let it dry, then heat it to soften it. Apply 10g-20g of plaster to each 8 square centimeter area on a cotton cloth. Example

[0036] The formula in this embodiment consists of the following ingredients in parts by weight: 16 parts Gastrodia elata, 12 parts Cimicifuga foetida, 1.5 parts Scorpion, 4.5 parts Centipede, 4 parts Silkworm, 8 parts Earthworm, 4 parts Cicada slough, 4.5 parts Snake slough, 1.5 parts Pangolin scales, 1.5 parts Borneol, 200 parts Sesame oil, and 40 parts Lithium sibiricum. The preparation method includes the following steps: 1) Mix Gastrodia elata, Cimicifuga foetida, scorpion, centipede, white silkworm, earthworm, cicada slough, snake slough and pangolin according to the weight parts, add sesame oil, soak at room temperature for 6-8 days, then heat to extract the oil, filter out the herbs to obtain medicinal oil; 2) Heat the medicinal oil to 200℃-230℃, stirring and heating until it forms beads when dripped into water. Add litharge to the medicinal oil, heat to 250℃-270℃, stirring and heating until it forms a paste when dripped into water. Pour it into water and soak for 3-5 days to obtain the plaster. 3) Remove the plaster from the water, let it dry, then heat it to soften it. Apply 10g-20g of plaster to each 8 square centimeter area on a cotton cloth.

[0037] The clinical practice summary of this invention is as follows: The present invention provides a method for using a topical ointment for treating shingles: Heat the ointment and apply it to the affected area. One ointment is used for 7 days, and one course of treatment consists of one ointment. Cure is achieved in 1-2 courses of treatment. The ointment can be used continuously between courses of treatment.

[0038] Clinical precautions: 1. The patient's affected skin and instruments must be disinfected and aseptic procedures performed to prevent infection; 2. Avoid staying up late and getting angry during use; 3. Use with caution if the affected skin is inflamed or broken, or if the patient has an allergic constitution.

[0039] The main symptoms are as follows: The main symptoms of shingles include: Before the rash appears, there may be mild fatigue, low-grade fever, loss of appetite, and other systemic symptoms. The affected skin feels burning or has neuralgia, and is noticeably sensitive to touch, lasting 1-3 days. The rash may also appear without any prodromal symptoms. Common sites are, in order of frequency, the areas innervated by the intercostal nerves, cervical nerves, trigeminal nerve, and lumbosacral nerves. The affected area often first appears as an erythematous patch, quickly followed by millet-sized to soybean-sized papules, clustered but not merging, which then rapidly develop into vesicles. The vesicle walls are tense and shiny, the fluid is clear, and the periphery is surrounded by a red halo. The skin between the clusters of vesicles is normal. The lesions are arranged in a band-like pattern along a peripheral nerve, usually occurring on one side of the body and generally not crossing the midline. Neuralgia is a characteristic symptom of this disease and may appear before or accompany the skin lesions; it is often more severe in elderly patients. The rash may include one or more of the above symptoms.

[0040] The main symptoms of postherpetic neuralgia are: it occurs after infection with the herpes zoster virus, and the pain persists even after the blisters disappear. It is easily aggravated by changes in weather, causing local nerve pain and itching. The pain lasts for more than a month after the blisters disappear, and in some cases, the pain can even last for more than ten years.

[0041] The main symptom of breast nodules is cyclical breast pain. Initially, it presents as a diffuse, throbbing pain, with tenderness most pronounced in the upper outer and upper middle parts of the breast. The pain intensifies before menstruation and decreases or disappears after menstruation. In severe cases, the pain is persistent both before and after menstruation. Sometimes the pain radiates to the armpit, shoulder, back, and upper limbs; one or more of the above symptoms may also be present.

[0042] The main symptoms of benign lymphoma: Diagnosis confirmed by CT scan; the lymphadenoma is benign. Skin lesions are usually solitary. Benign lymphomas appear as purplish-red, semi-circular raised lesions, which may be nodular, papular, or merge into plaques. They have clear borders, a relatively firm texture, and a thin, smooth epidermis without desquamation or ulceration. They commonly occur on the head, face, neck, areola, armpits, scrotum, and limbs; and may present with one or more of the above symptoms.

[0043] Boils: They begin as small, hard, red, swollen, and painful nodules on the skin, which are cone-shaped and tender to the touch. Then, a yellowish-white pustule appears on the top of the nodule, surrounded by a red hard surface. The patient feels itching, burning, and throbbing pain in the area. Later, the pustule ruptures, and after a small amount of pus is discharged, the pain is relieved. Alternatively, a pus plug may form at the top of the nodule, separate from the surrounding tissue, and fall off. The inflammation gradually subsides, and the wound heals on its own.

[0044] Based on the improvement of the above symptoms, the treatment is categorized as cured, significantly effective, and ineffective. Cured means all symptoms are relieved and pain disappears within the treatment course; significantly effective means some symptoms are relieved within the treatment course, while others remain unaffected; ineffective means no improvement is observed in the patient's symptoms within the treatment course. As described above, the total effective rate is the sum of the overall cure rate and the partial significant improvement rate.

[0045] Table 1 shows the efficacy statistics of two courses of treatment for shingles patients. For each example, 100 cases were randomly selected, with 50% male and 50% female, and the patients' ages ranging from 30 to 70 years. Each case used one example of the topical ointment for treating shingles until the end of the treatment course, without changing the medication midway. The statistical results are shown in Table 1: Table 1. Statistical analysis of treatment efficacy for herpes zoster. unit Example 1 Example 2 Example 3 Example 4 Example 5 cure rate % 95 95 93 92 92 apparent efficiency % 3 1 4 1 3 inefficiency % 2 4 3 7 5 Overall efficiency % 98 96 97 93 95 As shown in Table 1, the overall effective rate for treating shingles reached 93%-98%, and the cure rate reached 92%-95%. One year after the patients in the table above stopped using the topical ointment for treating shingles of this invention, a follow-up visit was conducted on the cured patients in the table above: none of the cured patients had any sequelae symptoms after the follow-up visit.

[0046] II. Table 2 shows the efficacy statistics of two courses of treatment for patients with postherpetic neuralgia. Forty cases were randomly selected for each example, with 50% male and 50% female, aged 45-70 years, and with a disease duration ranging from several months to 8 years. Each case used one example of the topical ointment for treating herpes zoster until the end of the treatment course, without changing the medication midway. The statistical results are shown in Table 2: Table 2. Statistical analysis of treatment efficacy for postherpetic neuralgia unit Example 1 Example 2 Example 3 Example 4 Example 5 cure rate % 84 80 81 87 79 apparent efficiency % 15 16 17 11 17 inefficiency % 1 4 2 2 4 Overall efficiency % 99 96 98 98 96 As shown in Table 2, the effective rate of treatment for postherpetic neuralgia reaches 99%-100%, and the cure rate is 79%-85%. More than 95% of patients reported pain relief within 24 hours of the first use, and significant pain relief was felt by the 3rd to 6th day of use.

[0047] III. Table 3 shows the efficacy statistics of one course of treatment for boils. 100 cases were randomly selected for each example, with an equal number of males and females, and the patients' ages ranging from 28 to 40 years. Each patient used one example of the topical ointment for treating herpes zoster until the end of the treatment course, without changing the medication midway. The statistical results are shown in Table 3: Table 3. Statistical analysis of the therapeutic effects of boils unit Example 1 Example 2 Example 3 Example 4 Example 5 cure rate % 97 95 92 93 91 apparent efficiency % 3 2 6 2 7 inefficiency % 0 3 2 5 2 Overall efficiency % 100 97 98 95 98 As shown in Table 3, the effective rate of treating boils reaches 97%-100%.

[0048] IV. Table 4 shows the efficacy statistics of two treatment courses for breast nodules. Forty cases were randomly selected for each example; all patients were female, aged 25-45 years. Each patient used one of the topical ointments for treating herpes zoster from one example until the end of the treatment course, without changing the medication midway. The statistical results are shown in Table 4: Table 4. Statistical analysis of treatment efficacy for breast nodules. unit Example 1 Example 2 Example 3 Example 4 Example 5 cure rate % 85 89 85 76 75 apparent efficiency % 7 6 9 14 17 inefficiency % 8 5 6 10 8 Overall efficiency % 92 95 94 90 92 As shown in Table 4, the effective rate of breast nodule treatment reaches 90%-95%.

[0049] Table 5 shows the efficacy statistics of two treatment courses for benign lymphoma. There were 8 males and 15 females, aged 10-42 years. Each case used one of the topical ointments for treating herpes zoster as described in this example until the end of the treatment course, without changing the medication midway. The statistical results are shown in Table 5: Table 5. Statistical analysis of treatment outcomes for benign lymphoma. unit Example 1 Example 2 Example 3 Total number of cases example 10 8 5 Number of cured cases example 7 5 5 Number of cases with significant effect example 2 3 0 Invalid cases example 1 0 2 As can be seen from Table 5, the topical ointment for treating herpes zoster of the present invention has a good therapeutic effect on benign lymphoma.

[0050] In clinical practice, the applicant found that Examples 1-6 were significantly effective in treating pain caused by the above-mentioned conditions. After one course of treatment, more than 80% of patients experienced pain relief, and after two courses of treatment, the rate increased to more than 95% of patients.

[0051] Although the above embodiments have provided a detailed description of the present invention, they are only some embodiments of the present invention, and not all embodiments. People can obtain other embodiments based on these embodiments without creative effort, and these embodiments all fall within the protection scope of the present invention.

Claims

1. A topical ointment for treating shingles, characterized in that, The ingredients include the following parts by weight: Gastrodia elata 16-20 parts, Cimicifuga foetida 8-12 parts, Scorpion 1.5-4.5 parts, Centipede 1.5-4.5 parts, Silkworm 4-8 parts, Earthworm 4-8 parts, Cicada slough 4-8 parts, Snake slough 1.5-4.5 parts, Pangolin scales 1.5-4.5 parts, Borneol 0.5-1.5 parts, Sesame oil 160-300 parts, and Litharge 40-80 parts.

2. The topical ointment for treating herpes zoster according to claim 1, characterized in that, The ingredients include the following parts by weight: Gastrodia elata 17-19 parts, Cimicifuga foetida 9-11 parts, Scorpion 2-4 parts, Centipede 2-4 parts, Silkworm 5-7 parts, Earthworm 5-7 parts, Cicada slough 5-7 parts, Snake slough 2-4 parts, Pangolin scales 2-4 parts, Borneol 0.8-1.2 parts, Sesame oil 190-280 parts, Litharge 30-70 parts.

3. The topical ointment for treating herpes zoster according to claim 1, characterized in that, The ingredients include the following parts by weight: 18 parts Gastrodia elata, 10 parts Cimicifuga foetida, 3 parts Scorpion, 3 parts Centipede, 6 parts Silkworm, 6 parts Earthworm, 6 parts Cicada slough, 3 parts Snake slough, 3 parts Pangolin scales, 1 part Borneol, 240 parts Sesame oil, and 60 parts Lithium sibiricum.

4. The topical ointment for treating herpes zoster according to claim 1, characterized in that, It also includes the following ingredients by weight: 4-6 parts frankincense and 5-7 parts myrrh.

5. A topical ointment for treating herpes zoster according to claim 4, characterized in that, It also includes the following ingredients by weight: 5 parts frankincense and 6 parts myrrh.

6. A method for preparing a topical ointment for treating herpes zoster according to any one of claims 1-5, characterized in that, Includes the following steps: 1) Mix Gastrodia elata, Cimicifuga foetida, scorpion, centipede, white silkworm, earthworm, cicada slough, snake slough and pangolin according to the weight parts, add sesame oil, soak at room temperature for 6-8 days, then heat to extract the oil, filter out the herbs to obtain medicinal oil; 2) Heat the medicinal oil until it forms beads when dropped into water, add litharge to the medicinal oil, heat and mix until it forms a paste when dropped into water, pour it into water to soak, and obtain the plaster; 3) Remove the plaster from the water, let it dry, then heat it and spread it on a cotton cloth to obtain the plaster.

7. The method for preparing a topical ointment for treating herpes zoster according to claim 6, characterized in that, Step 3) The specific operation of heating the plaster is as follows: heat the plaster to soften it, apply 10g-20g of plaster to each 8 square centimeter area, and apply the plaster to the cotton cloth.