Low temperature photothermal synergistic nanoparticles for near-infrared triggered phase transition controlled release and preparation and application thereof

Abstract

This invention belongs to the field of biomedical materials technology, and relates to a near-infrared triggered phase change controlled release low-temperature photothermal synergistic nanoparticle, its preparation, and application. The low-temperature photothermal synergistic nanoparticle includes a phase change layer and a photothermal core; the phase change layer coats the photothermal core; the phase change layer is loaded with a water-soluble antibacterial drug; the photothermal core is used to convert absorbed near-infrared light energy into heat energy and cause the phase change material to undergo a phase change; the phase change material, water-soluble antibacterial drug, and photothermal agent are dispersed and mixed to obtain the low-temperature photothermal synergistic nanoparticle; the low-temperature photothermal synergistic nanoparticle is added to a spinning solution to obtain an electrospinning solution, and then electrospinned to obtain an infrared triggered phase change controlled release low-temperature photothermal synergistic dressing. In this invention, the photothermal unit, phase change unit, and drug unit in the nanoparticle are tightly coupled at the nanoscale; during preparation, the particles are integrated through phase change-assisted in-situ composite and coating processes; and in application, the problems of high interfacial thermal resistance and low heat-drug synergistic efficiency are solved.

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