Mechanical property controllable silk fibroin hard material, preparation method and application thereof

Abstract

The application provides a silk fibroin hard material with controllable mechanical properties and a preparation method and application thereof, and belongs to the field of medical material preparation. The preparation method comprises the following steps: a silk fibroin solution is processed into Silk I type insoluble matter through low-temperature freezing and annealing treatment, the Silk I type insoluble matter is dried, crushed, and granulated to obtain regenerated silk fibroin powder with different particle sizes, and then the regenerated silk fibroin powder is processed through hot pressing to obtain silk fibroin hard materials with different mechanical properties. In the application, hot pressing of Silk I structure silk fibroin is used to replace traditional hot pressing of amorphous silk fibroin, so that the high-energy-consumption and time-consuming freeze-drying process is avoided; and the particle size of the regenerated silk fibroin powder is controlled through granulation treatment, the mechanical properties of the silk fibroin hard material are regulated, the mechanical properties required by the repair material in different application scenarios are adapted, and the application can be used in the fields of orthopedics and tissue engineering.

Images