一种二酰胺荚醚及其合成方法
The synthesis of diamide pod ethers via a three-step reaction of 1,4-dioxane-2-one with amines solves the problems of low yield and environmental unfriendliness in existing technologies, achieving efficient and stable synthesis of diamide pod ethers suitable for industrial applications.
CN122167300BActive Publication Date: 2026-07-17SICHUAN CURIE ISOTOPE TECHNOLOGY CO LTD
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SICHUAN CURIE ISOTOPE TECHNOLOGY CO LTD
- Filing Date
- 2026-05-11
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing methods for synthesizing diamide podyl ethers suffer from low yields, environmental unfriendliness, and difficulty in purification.
Method used
Using 1,4-dioxane-2-one as a raw material, a three-step reaction is carried out: reacting with amine to generate 2-(2-hydroxyethoxy)amide, oxidizing to generate oxamonosubstituted amide, and then condensing with dialkylamine to prepare diamide ether. This avoids the use of highly corrosive and volatile reagents and simplifies the purification process.
Benefits of technology
It is easy to operate, the intermediates are stable and easy to purify, and the yield of each of the three steps is high, with an overall yield of over 61%, giving it advantages for industrial application.
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Figure CN122167300B_ABST
Abstract
本发明涉及二酰胺荚醚合成技术领域，具体涉及一种二酰胺荚醚及其合成方法，该方法以1,4‑二氧六环‑2‑酮作为原料，通过1,4‑二氧六环‑2‑酮与二烷基胺发生开环反应得到中间体2‑(2‑羟基乙氧基)酰胺，后再通过氧化将羟基氧化为羧基生成另一中间体氧杂单取代酰胺，最后将氧杂单取代酰胺和二烷基胺进行缩合制备出二酰胺荚醚，避免了酰氯，二甘醇酐等中间体的生成，且合成路线操作简便、易于纯化处理，总收率在61%以上，满足该类产品日益增长的工业化需求，为批量化生产打下了良好基础。
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