Preparation and purification of an antibacterial compound acetate

By using water as a solvent in the preparation and purification of chlorhexidine acetate, and by controlling the reaction temperature and performing multiple purification processes, the problems of complex processes and difficult impurity removal in the existing technology have been solved, and high-yield and high-purity chlorhexidine acetate products have been achieved.

CN122167315APending Publication Date: 2026-06-09BEIJING SUN-NOVO PHARM RES CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING SUN-NOVO PHARM RES CO LTD
Filing Date
2024-12-06
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

The preparation process of chlorhexidine acetate in the prior art is complex and cumbersome, and it is difficult to effectively control the impurity content, especially the removal effect of impurity IM-06 is not good.

Method used

Water is used as the salt-forming solvent, and the reaction temperature is controlled at 75℃~85℃ and the cooling crystallization temperature is controlled at 0℃~30℃, preferably 10℃~30℃. In combination with one or two purification processes, an appropriate amount of water is used for stirring, centrifugation, rinsing and drying to obtain high-purity chlorhexidine acetate.

Benefits of technology

High yield and high purity of chlorhexidine acetate were achieved, while the impurity content was effectively controlled, especially the removal effect of impurity IM-06 was significantly improved.

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Abstract

The application discloses a preparation and refining method of an antibacterial compound acetate, and the preparation method comprises the following steps: adding the antibacterial compound into water, stirring uniformly, adding acetic acid, and reacting at 75 DEG C-85 DEG C; after the reaction is completed, cooling and crystallization are carried out to obtain the antibacterial compound acetate crude product; the preparation method comprises the following steps: heating water to 75 DEG C-85 DEG C, adding the antibacterial compound acetate crude product, stirring and dissolving, cooling and crystallization, centrifugation, washing and drying to obtain the antibacterial compound acetate refined product. The antibacterial compound acetate crude product and the refined product have good yield and purity.
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