Gastrodin and its extraction and purification method and application

By extracting and purifying Gastrodia elata polysaccharide GBP, the problems of insufficient structural identification of Gastrodia elata polysaccharide and the toxic side effects of traditional gastric mucosal damage drugs have been solved, achieving a highly efficient and safe gastric mucosal protection effect, and providing high-purity Gastrodia elata polysaccharide for use in gastric protection foods and drugs.

CN122167604APending Publication Date: 2026-06-09NANJING UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING UNIV OF SCI & TECH
Filing Date
2024-12-06
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

The structural identification and bioactivity research of Gastrodia elata polysaccharide in the current technology are still in the early stages, and traditional drugs for treating gastric mucosal damage have toxic side effects and are difficult to effectively protect against ethanol-induced gastric mucosal damage.

Method used

A homogeneous extraction and purification method for Gastrodia elata polysaccharide GBP was developed, including steps such as reflux extraction, alcohol precipitation, Sevag reagent treatment, dialysis, and chromatography. High-purity Gastrodia elata polysaccharide GBP was obtained by purification using a DEAE-52 cellulose column and a Sephacryl S-300HR column, which can be used to prepare gastric protective functional foods or drugs.

Benefits of technology

It improved the extraction rate and purity of Gastrodia elata polysaccharide, and achieved a significant protective effect against ethanol-induced gastric mucosal damage. It was superior to the positive control drug omeprazole and had a highly efficient and safe gastric protective effect.

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Abstract

The application discloses a Gastrodia elata polysaccharide, an extraction and purification method thereof and application of the Gastrodia elata polysaccharide. The Gastrodia elata polysaccharide GBP of the application is a homogeneous polysaccharide, and a main chain of the homogeneous polysaccharide is formed by mutual connection of→4)-alpha-D-Glcp-(1→. Branch chains of the homogeneous polysaccharide are mainly formed by alpha-D-Glcp-(1→, →4,6)-alpha-D-Glcp-(1→, →2,4)-alpha-D-Glcp-(1→ and →3,4)-alpha-D-Glcp-(1→. The Gastrodia elata polysaccharide GBP has a certain protective effect on ethanol-induced gastric mucosa injury, can be used for preparing functional products with a stomach-protecting effect, and improves food and medical values of the Gastrodia elata polysaccharide.
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