一种利用糠酰氯衍生-液相色谱串联质谱检测类固醇激素的方法
By selectively acylating estrone and estradiol with furfural chloride and combining it with liquid chromatography-tandem mass spectrometry detection, the problems of detection complexity and harsh reaction conditions in existing technologies have been solved, achieving high sensitivity and high accuracy in the quantification of trace estrone and estradiol.
CN122171728BActive Publication Date: 2026-07-17GUANGDONG CHIMELONG GRP CO LTD
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- GUANGDONG CHIMELONG GRP CO LTD
- Filing Date
- 2026-05-13
- Publication Date
- 2026-07-17
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Figure CN122171728B_ABST
Abstract
本发明公开了一种利用糠酰氯衍生‑液相色谱串联质谱检测类固醇激素的方法。本发明采用糠酰氯对类固醇激素进行衍生化，联合液相色谱串联质谱可实现生物基质中痕量雌酮、雌二醇等类固醇激素的高灵敏、精准定量。与现有技术相比，本发明提供的利用糠酰氯衍生‑液相色谱串联质谱检测类固醇激素的方法回收率高，线性范围广，线性关系良好，检出限低，且反应条件温和、反应流程简化。
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