An online impurity detection device and method for vitamin k1 intermediate

CN122193455APending Publication Date: 2026-06-12SHANDONG GUANGTONGBAO PHARMA

Patent Information

Authority / Receiving Office: CN · China
Patent Type: Applications(China)
Current Assignee / Owner: SHANDONG GUANGTONGBAO PHARMA
Filing Date: 2026-04-10
Publication Date: 2026-06-12

AI Technical Summary

Technical Problem

Existing vitamin K1 intermediate detection devices suffer from significant nitrogen loss when preparing solutions in an inert gas environment, resulting in cumbersome and time-consuming operations. Furthermore, they cannot simultaneously prepare test and control solutions, affecting detection efficiency and stability.

Method used

It adopts a brown, low-transparency mixing cylinder with a built-in nitrogen environment and a piston-separated chamber structure. Combined with an electric cylinder and a height sensor, the piston position is precisely controlled, enabling precise quantitative control of the mobile phase. When preparing test samples and control solutions, there is no need to break the sealed environment. The chamber switching is achieved through a rotary conversion mechanism, realizing fully automated operation.

Benefits of technology

It effectively avoids light and oxidation, reduces nitrogen consumption, improves solution mixing uniformity and detection accuracy, shortens the detection cycle, reduces human error, and achieves efficient and reliable impurity detection.

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Abstract

This application relates to an online impurity detection device and method for vitamin K1 intermediates, and belongs to the field of impurity detection technology. It includes a base plate with a liquid chromatograph mounted on its upper side, a dispensing mechanism, and a switching mechanism. The dispensing mechanism's dispensing cylinder has a built-in nitrogen environment. The piston position is precisely controlled by an electric cylinder and a height sensor to limit the main chamber volume, achieving precise quantitative control of the mobile phase addition. The main chamber is free of excess air, improving solution mixing uniformity and efficiency, and ensuring consistency between the test solution and the control solution. The piston assembly automatically seals when the mobile phase is full, avoiding detection deviations caused by excessive or insufficient solution. The rotating switching mechanism allows for convenient switching of the two chambers at both ends of the dispensing cylinder and pipeline connection. Switching between dispensing, injection, and extraction positions does not require disrupting the sealed environment inside the dispensing cylinder, maintaining a leak-proof nitrogen atmosphere throughout the process and preventing contact with outside air.

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