Non-aqueous drug microbiological test extractor

Abstract

The application discloses a non-water-soluble medicine microbial test extractor, and particularly relates to the technical field of medicine detection, which comprises a test table, rotating shafts are rotationally connected to the two sides of the test table, a placing frame is fixedly connected between the two groups of rotating shafts, a clamping assembly is arranged on the inner side of the placing frame, a mounting frame is fixedly connected to one side of the test table, a swinging assembly is arranged on the outer side of the mounting frame, the clamping assembly is matched with the swinging assembly, and the swinging assembly is used for fixing and shaking the reagent bottle, so that the fixing and automatic shaking of the reagent bottle are integrated and cooperatively operated, a whole structure of multi-component linkage is formed on the basis of the test table, the traditional operation mode of repeatedly shaking the reagent bottle by manual holding is replaced, the labor intensity of the operator is reduced, meanwhile, the early extraction and mixing operation of the non-water-soluble medicine microbial test is more standardized and efficient, and stable and reliable equipment support is provided for subsequent test work.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical testing, and in particular to an extractor for the microbial testing of non-water-soluble drugs. Background Technology

[0002] In the fields of pharmaceutical research and development and drug quality testing, microbial testing of non-water-soluble drugs is a key step in controlling drug safety. Extraction and mixing, as the core pretreatment step for microbial testing of non-water-soluble drugs, directly affects the accuracy and reliability of subsequent test results.

[0003] Currently, the extraction and mixing of non-water-soluble drugs in the industry still commonly relies on manual hand-held shaking of reagent bottles. This traditional method has several technical drawbacks: First, it is difficult to maintain a uniform force, frequency, and rhythm during manual shaking, which can lead to insufficient mixing of the non-water-soluble drug and the diluent, incomplete release of microorganisms, directly affecting the accuracy of subsequent test results and even causing false negatives or false positives. Second, repeated manual shaking consumes a lot of manpower, and prolonged operation can easily cause hand fatigue, significantly reducing the efficiency of testing, especially when testing batches of samples, where the labor intensity and time consumption are even more pronounced. Third, the lack of effective fixation of reagent bottles during manual shaking can easily lead to slippage and tipping, causing sample loss and potentially resulting in reagent leakage, laboratory contamination, and other safety hazards. Therefore, a non-water-soluble drug microbial testing extractor is needed to solve these problems. Summary of the Invention

[0004] The main objective of this invention is to provide a non-water-soluble drug microbial testing extractor that can effectively solve the above-mentioned problems.

[0005] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0006] A non-water-soluble drug microbial testing extractor includes a testing platform. Rotating shafts are rotatably connected to both sides of the testing platform. A placement frame is fixedly connected between the two sets of rotating shafts. A clamping assembly is provided inside the placement frame. A mounting frame is fixedly connected to one side of the testing platform. A rocking assembly is provided outside the mounting frame. The clamping assembly and the rocking assembly cooperate to fix the position of the reagent bottle and to shake and mix it.

[0007] Preferably, the clamping assembly includes a rotating plate rotatably connected to the top of the inner side of the placement frame, two sets of sliding rods slidably connected to the top of the inner side of the placement frame, a clamping arc plate fixedly connected to the lower end of the sliding rods, and the sliding rods and the rotating plate are hinged together by a connecting rod.

[0008] Preferably, a gear A is fixedly connected to one end of the rotating plate inside the placement frame, a handle is rotatably connected to the top of the placement frame, and a gear B is fixedly connected to one end of the handle inside the placement frame.

[0009] Preferably, gear B is meshed with gear A, and a damping sleeve is fixedly connected to the top of the placement frame, with the damping sleeve sleeved on the outside of the throttle rotation rod.

[0010] Preferably, the rocking assembly includes a rotating rod rotatably connected to one side of the top of the mounting frame, a sector gear fixedly connected to the end of the rotating rod, a transmission plate fixedly connected to the outer side of the rotating rod, and a sliding groove formed on the inner side of the transmission plate.

[0011] Preferably, a drive motor is fixedly connected to the inner side of the mounting bracket, and an L-shaped rotating rod is fixedly connected to the output end of the drive motor, with one end of the L-shaped rotating rod located inside the sliding groove and slidably connected to the sliding groove.

[0012] Preferably, a positioning plate is fixedly connected to the bottom inner side of the placement frame, and a set of rotating shafts are fixedly connected to the end of a transmission gear, and the transmission gear and the sector gear are meshed together.

[0013] Compared with the prior art, the present invention has the following beneficial effects:

[0014] 1. The overall equipment achieves integrated operation of reagent bottle fixing and automatic shaking mixing. Based on the testing table, it forms a multi-component precise linkage structure, effectively replacing the traditional operation method of manually shaking reagent bottles repeatedly, reducing the labor intensity of operators. At the same time, it makes the preliminary extraction and mixing operation of non-water-soluble drug microbial testing more standardized and efficient, providing stable and reliable equipment support for subsequent testing work. Moreover, the tight connection of each component and the precise power transmission ensure the stability of equipment operation.

[0015] 2. The clamping assembly adopts a linkage design of gear meshing, connecting rod hinge and sliding fit, which realizes convenient, firm and adjustable clamping and fixing of reagent bottles. It is simple to operate and adaptable to the clamping needs of reagent bottles of different sizes. The limiting function of the damping sleeve can effectively prevent the handle from turning on its own due to the swing and vibration of the equipment, ensuring that the clamping arc plate always holds the reagent bottle stably. This fundamentally avoids the situation of the reagent bottle loosening, tipping or falling off during the swing mixing process, and lays a solid foundation for the safe and effective mixing of reagents.

[0016] 3. The swing assembly, through a structural design combining motor drive and mechanical transmission, successfully converts circular motion into reciprocating oscillation, providing stable and continuous swinging power to the placement frame. This ensures a uniform and controllable swinging rhythm for the reagent bottles, effectively improving the uniformity and efficiency of reagent mixing compared to manual shaking. Furthermore, the smooth overall transmission process and precise power delivery of the assembly guarantee the stability and regularity of the swinging motion, allowing non-water-soluble drugs to mix thoroughly with the extraction reagents, improving the extraction effect, and thus ensuring the accuracy of subsequent microbiological test results. Attached Figure Description

[0017] Figure 1 This is a front view of the present invention.

[0018] Figure 2 This is a side view of the present invention;

[0019] Figure 3 This is a partial structural schematic diagram of the present invention;

[0020] Figure 4 This is a schematic diagram of the clamping component structure of the present invention;

[0021] Figure 5 This is a schematic diagram of the clamping component structure of the present invention;

[0022] Figure 6 This is a schematic diagram of the swing component structure of the present invention;

[0023] Figure 7 This is a schematic diagram of the exploded structure of the swing assembly of the present invention.

[0024] In the diagram: 1. Inspection table; 2. Rotating shaft; 3. Placement frame; 4. Mounting bracket; 5. Clamping assembly; 501. Rotating plate; 502. Sliding rod; 503. Clamping arc plate; 504. Connecting rod; 505. Gear A; 506. Turn handle; 507. Gear B; 508. Damping sleeve; 6. Swing assembly; 601. Rotating rod; 602. Sector gear; 603. Transmission plate; 604. Sliding groove; 605. Drive motor; 606. L-shaped rotating rod; 7. Positioning plate; 8. Transmission gear. Detailed Implementation

[0025] To make the technical means, creative features, objectives and effects of this invention easier to understand, the invention will be further described below in conjunction with specific embodiments.

[0026] like Figures 1-2As shown, a non-water-soluble drug microbial testing extractor includes a testing platform 1. Rotating shafts 2 are rotatably connected to both sides of the inner side of the testing platform 1. A placement frame 3 is fixedly connected between the two sets of rotating shafts 2. A clamping component 5 is provided inside the placement frame 3. A mounting frame 4 is fixedly connected to one side of the testing platform 1. A rocking component 6 is provided outside the mounting frame 4. The clamping component 5 cooperates with the rocking component 6 to fix the position of the reagent bottle and to shake and mix it. A positioning plate 7 is fixedly connected to the bottom of the inner side of the placement frame 3. A transmission gear 8 is fixedly connected to the end of one set of rotating shafts 2, and the transmission gear 8 is meshed with a sector gear 602.

[0027] As described above, the system achieves integrated operation of reagent bottle fixing and automatic shaking mixing, replacing manual hand-held shaking. This reduces the labor intensity of operators and ensures the uniformity and stability of reagent mixing. Furthermore, the precise linkage of multiple components makes the pre-mixing operation of the extraction test more standardized and efficient. First, the reagent bottle is placed in the placement frame 3, where the positioning plate 7 at the bottom of the inner side of the placement frame 3 positions and supports the bottle. Then, the clamping component 5 inside the placement frame 3 firmly clamps and fixes the bottle. Next, the shaking component 6 on the mounting frame 4 on one side of the testing table 1 is activated. The sector gear 602 of the shaking component 6 meshes with the transmission gear 8 at the end of one set of rotating shafts 2, driving the two sets of rotating shafts 2 to rotate synchronously on both sides inside the testing table 1. This, in turn, causes the placement frame 3, which is fixedly connected to the rotating shafts 2, to swing left and right. The placement frame 3, carrying the reagent bottle fixed inside, completes the shaking and mixing. The overall structure features tight connections between all components and precise power transmission, providing stable equipment support for the extraction operation of non-water-soluble drug microbial testing.

[0028] like Figures 3-5 As shown, the clamping assembly 5 includes a rotating plate 501 rotatably connected to the top of the inner side of the placement frame 3. Two sets of sliding rods 502 are slidably connected to the top of the inner side of the placement frame 3. A clamping arc plate 503 is fixedly connected to the lower end of the sliding rods 502. The sliding rods 502 and the rotating plate 501 are hinged together by a connecting rod 504. A gear A 505 is fixedly connected to one end of the rotating plate 501 located inside the placement frame 3. A handle 506 is rotatably connected to the top of the placement frame 3. A gear B 507 is fixedly connected to one end of the handle 506 located inside the placement frame 3. The gear B 507 is meshed with the gear A 505. A damping sleeve 508 is fixedly connected to the top of the placement frame 3, and the damping sleeve 508 is sleeved on the outside of the rotating rod of the handle 506.

[0029] As described above, this component provides convenient, secure, and adjustable clamping and fixing of reagent bottles. It is simple to operate and offers strong clamping stability, effectively preventing reagent bottles from loosening, tipping, or falling off during mixing. Manually rotating the handle 506 at the top of the placement frame 3 rotates the gear B507 on its inner side. Gear B507 meshes with gear A505 at the end of the rotating plate 501, causing the rotating plate 501 at the top inner side of the placement frame 3 to rotate synchronously. The rotating plate 501 then drives the placement frame 3 via the hinged connecting rod 504. The two sets of sliding rods 502 on the inner top slide synchronously in the vertical direction, thereby driving the clamping arc plate 503 at the lower end of the sliding rod 502 to move closer to or away from the reagent bottle, thus completing the clamping or releasing of reagent bottles of different specifications; at the same time, the damping sleeve 508 on the outside of the rotating rod of the handle 506 is fitted on the top of the placement frame 3, which can provide damping limit for the handle 506, preventing the handle 506 from rotating on its own due to the swaying and vibration of the equipment, ensuring that the clamping arc plate 503 always maintains a stable clamping state on the reagent bottle, and providing a reliable fixed foundation for subsequent swaying and mixing operations;

[0030] The clamping arc plate 503 is made of a composite of food-grade silicone and hard plastic. The silicone layer is attached to the clamping contact surface, which increases the friction with the reagent bottle to improve the clamping firmness, and also prevents the hard contact from scratching the reagent bottle. At the same time, the arc structure is designed to adapt to reagent bottles of various sizes, and can be compatible with conventional laboratory reagent bottles with diameters of 20-80mm. The positioning plate 7 is made of elastic rubber with circular positioning grooves on the surface. The grooves are treated with anti-slip texture, which not only achieves precise positioning of the bottom of the reagent bottle, but also buffers the vibration during the swinging process, further improving the stability of the reagent bottle.

[0031] All gear transmission components are precision-machined from 45# steel, and the surface is hardened to improve hardness and wear resistance. The gear meshing clearance is controlled within 0.05-0.1mm to ensure accurate and smooth power transmission and reduce noise and wear during transmission. The damping sleeve 508 is made of nitrile rubber with an internal metal bushing to enhance structural strength. The clearance between it and the throttle 506 rotating rod is 0.02-0.04mm, providing stable damping limiting force and excellent aging resistance, ensuring that it does not easily lose its damping effect after long-term use.

[0032] A self-lubricating copper sleeve is installed at the sliding contact between the sliding rod 502 and the placement frame 3 to reduce frictional resistance during sliding and prevent jamming. The copper sleeve also has wear-resistant properties, extending the equipment's service life. All rotating connections are equipped with miniature deep groove ball bearings to improve rotational flexibility, reduce frictional wear between components, and a dustproof seal is installed on the outside of the bearings to prevent laboratory dust and reagent debris from entering and affecting rotation, ensuring long-term stable operation of the equipment.

[0033] like Figures 6-7As shown, the rocking assembly 6 includes a rotating rod 601 rotatably connected to one side of the top of the mounting frame 4. A sector gear 602 is fixedly connected to the end of the rotating rod 601. A transmission plate 603 is fixedly connected to the outer side of the rotating rod 601. A sliding groove 604 is provided on the inner side of the transmission plate 603. A drive motor 605 is fixedly connected to the inner side of the mounting frame 4. An L-shaped rotating rod 606 is fixedly connected to the output end of the drive motor 605. The L-shaped rotating rod 606 is located inside the sliding groove 604 and is slidably connected to the sliding groove 604 at one end.

[0034] As described above, the swing assembly 6, through a structural design combining motor drive and mechanical transmission, realizes the conversion of circular motion into reciprocating oscillation, providing stable and continuous swing power for the placement frame 3, replacing manual hand-held shaking, reducing labor intensity, and ensuring a uniform and controllable swing rhythm, thus improving the uniformity and efficiency of reagent mixing. Activating the drive motor 605 inside the mounting frame 4 causes the L-shaped rotating rod 606 to rotate in a circular motion. The end of the L-shaped rotating rod 606 located in the sliding groove 604 slides within the sliding groove 604 inside the transmission plate 603, thereby causing the transmission plate 603 to oscillate reciprocally. The rotating rod 601, fixedly connected to the transmission plate 603, reciprocates synchronously with the transmission plate 603 on one side of the top of the mounting frame 4. The sector gear 602 at the end of the rotating rod 601 also reciprocates synchronously, providing power output for the subsequent swinging of the placement frame 3. The overall transmission process is smooth, the power transmission is precise, and the stability and regularity of the swinging motion are guaranteed.

[0035] The drive motor 605 is a speed-regulating three-phase asynchronous motor with an IP65 protection rating. Its power is set from 0.2 to 0.75 kW, and its rated speed can be steplessly adjusted within the range of 0-1000 r / min. It can precisely control the swing rate according to reagent mixing requirements, adapting to the extraction and mixing conditions of various non-water-soluble drugs. Both the testing table 1 and the mounting frame 4 are integrally welded from 304 stainless steel, with polished and passivated surfaces for corrosion resistance and acid and alkali resistance, making them suitable for various laboratory reagent handling environments. Furthermore, the bottom of the testing table 1 is equipped with anti-slip rubber pads to improve the overall stability of the equipment during operation and prevent displacement during swinging.

[0036] The working principle of this invention is as follows:

[0037] The entire system is supported by the testing table 1. With the precise linkage of the clamping component 5 and the swing component 6, the system achieves integrated operation of fixing the reagent bottle and automatically swinging and mixing, replacing manual hand-held shaking operation, reducing labor intensity while ensuring the uniformity and stability of reagent mixing. In use, the reagent bottle is first placed in the placement frame 3. The positioning plate 7 at the bottom of the inner side of the placement frame 3 completes the bottom positioning and support of the reagent bottle. Then, the handle 506 at the top of the placement frame 3 is manually turned, which drives the gear B507 inside to rotate. The gear B507 meshes with the gear A505 at the end of the rotating plate 501, so that the rotating plate 501 at the top of the inner side of the placement frame 3 rotates synchronously. The rotating plate 501 then drives the two sets of sliding rods 502 at the top of the inner side of the placement frame 3 to slide synchronously in the vertical direction through the hinged connecting rod 504. This causes the clamping arc plate 503 at the lower end of the sliding rod 502 to approach the reagent bottle to complete the clamping. The damping sleeve 508, which is sleeved on the top of the placement frame 3 outside the rotating rod of the handle 506, can provide damping limit for the handle 506 to prevent the handle 506 from rotating on its own due to the swaying and vibration of the equipment, and ensure the stability of the clamping state.

[0038] After the reagent bottle is fixed, the drive motor 605 inside the mounting bracket 4 on one side of the test bench 1 is started. Its output end drives the L-shaped rotating rod 606 to rotate in a circular motion. The end of the L-shaped rotating rod 606 located in the sliding groove 604 slides in the sliding groove 604 inside the transmission plate 603, thereby driving the transmission plate 603 to swing back and forth. The rotating rod 601 fixedly connected to the transmission plate 603 rotates back and forth synchronously with the transmission plate 603 on the top side of the mounting bracket 4. The sector gear 602 at the end of the rotating rod 601 also rotates back and forth synchronously. The sector gear 602 then meshes with the transmission gear 8 at the end of one set of rotating shafts 2, driving the two sets of rotating shafts 2 to rotate back and forth synchronously on both sides inside the test bench 1. Finally, the placement frame 3 fixedly connected to the rotating shaft 2 carries the reagent bottle fixed inside to swing left and right, completing the automatic shaking and mixing of the reagent. The overall transmission process is smooth and the power transmission is precise, providing stable equipment support for the extraction operation of non-water-soluble drug microbial testing.

[0039] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of the present invention as claimed. The scope of protection of this invention is defined by the appended claims and their equivalents.

Claims

1. A microbial extraction apparatus for the testing of non-water-soluble drugs, comprising a testing table (1), characterized in that: The inspection table (1) has rotating shafts (2) rotatably connected to both sides inside. A placement frame (3) is fixedly connected between the two sets of rotating shafts (2). A clamping component (5) is provided inside the placement frame (3). A mounting frame (4) is fixedly connected to one side of the inspection table (1). A swinging component (6) is provided outside the mounting frame (4). The clamping component (5) and the swinging component (6) cooperate to fix the position of the reagent bottle and to shake and mix it.

2. The microbial extraction apparatus for non-water-soluble drugs according to claim 1, characterized in that: The clamping assembly (5) includes a rotating plate (501) rotatably connected to the top of the inner side of the placement frame (3). Two sets of sliding rods (502) are slidably connected to the top of the inner side of the placement frame (3). A clamping arc plate (503) is fixedly connected to the lower end of the sliding rod (502). The sliding rod (502) and the rotating plate (501) are hinged together by a connecting rod (504).

3. The microbial extraction apparatus for non-water-soluble drugs according to claim 2, characterized in that: The rotating plate (501) is fixedly connected to a gear A (505) at one end inside the placement frame (3), and a rotatable handle (506) is rotatably connected to the top of the placement frame (3). The rotatable handle (506) is fixedly connected to a gear B (507) at one end inside the placement frame (3).

4. The microbial extraction apparatus for non-water-soluble drugs according to claim 3, characterized in that: The gear B (507) is meshed with the gear A (505), and a damping sleeve (508) is fixedly connected to the top of the placement frame (3), and the damping sleeve (508) is sleeved on the outside of the rotating rod of the throttle (506).

5. The microbial extraction apparatus for non-water-soluble drugs according to claim 1, characterized in that: The rocking assembly (6) includes a rotating rod (601) rotatably connected to one side of the top of the mounting bracket (4). A sector gear (602) is fixedly connected to the end of the rotating rod (601). A transmission plate (603) is fixedly connected to the outside of the rotating rod (601). A sliding groove (604) is provided on the inner side of the transmission plate (603).

6. The microbial extraction apparatus for non-water-soluble drugs according to claim 5, characterized in that: A drive motor (605) is fixedly connected to the inner side of the mounting bracket (4). An L-shaped rotating rod (606) is fixedly connected to the output end of the drive motor (605), and one end of the L-shaped rotating rod (606) is slidably connected to the sliding groove (604) inside the sliding groove (604).

7. The microbial extraction apparatus for non-water-soluble drugs according to claim 5, characterized in that: The bottom inner side of the placement frame (3) is fixedly connected to a positioning plate (7), and a set of rotating shafts (2) are fixedly connected to a transmission gear (8) at their ends, and the transmission gear (8) meshes with the sector gear (602).

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