Application of white-bone earth fruit extract in promoting osteoblast differentiation and improving osteoporosis

An osteoblast differentiation promoter prepared by extracting Avicennia marina fruit solves the problem of limited efficacy of existing osteoporosis treatment drugs, enhances osteoblast differentiation and mineralization functions, and has good potential for industrial application.

CN122229905APending Publication Date: 2026-06-19GUANGDONG MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUANGDONG MEDICAL UNIV
Filing Date
2026-04-22
Publication Date
2026-06-19

AI Technical Summary

Technical Problem

Existing osteoporosis treatments have limited effects on improving osteogenic function and have adverse reactions, making it difficult to meet clinical needs. There is a need for a natural, safe, and effective osteoblast differentiation promoter.

Method used

An osteoblast differentiation promoter was prepared by using extracts of Avicennia marina fruit, which were extracted with n-butanol and then combined with ethyl acetate and n-butanol extraction, to promote the differentiation and mineralization functions of osteoblasts.

Benefits of technology

The extract of *Avicennia marina* fruit significantly promotes osteoblast differentiation and mineralization, exhibiting a good dose-dependent effect, and has potential application prospects for treating osteoporosis and promoting fracture repair.

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Abstract

This invention relates to the application of an extract from *Avicennia marina* fruit in promoting osteoblast differentiation and improving osteoporosis, and to the application of natural plant extracts in the prevention and treatment of bone metabolic diseases. This *Avicennia marina* fruit extract is obtained by extraction from *Avicennia marina* fruit using n-butanol. It can effectively promote osteoblast differentiation and mineralization, and can be developed into a drug for treating osteoporosis. Furthermore, this extract is derived from a natural plant, making it green, natural, and of reliable origin, thus possessing good potential for industrial development.
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