一种埃及血吸虫IPSE特异性纳米抗体及其在感染检测中的应用
By developing a Schistosoma egypseum IPSE-specific nanobody and constructing a dual-antibody sandwich detection system, the problems of complex sample processing, high cost, and low sensitivity in existing technologies have been solved. This enables non-invasive, simple, and efficient early infection detection, which is suitable for large-scale population screening in endemic areas.
CN122234212BActive Publication Date: 2026-07-17NANJING MEDICAL UNIV +1
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- NANJING MEDICAL UNIV
- Filing Date
- 2026-05-14
- Publication Date
- 2026-07-17
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Figure CN122234212B_ABST
Abstract
本发明公开一种埃及血吸虫IPSE特异性纳米抗体及其在感染检测中的应用，属于生物检测技术领域。所述纳米抗体为可特异性结合埃及血吸虫IPSE抗原的重链抗体可变区VHH片段，其氨基酸序列选自SEQ ID NO.30、SEQ ID NO.33、SEQ ID NO.34所示序列中的任意一种。本发明还提供了该纳米抗体的编码核酸、重组表达载体、工程宿主细胞，以及基于该纳米抗体构建的双抗体夹心检测试剂盒。所述纳米抗体亲和力高、稳定性好，配套检测体系最低检出限低至0.06 ng / mL，可实现尿液无创检测，适配埃及血吸虫病大规模现场筛查，为感染检测提供了高灵敏、便捷的技术方案。
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