Compositions and methods for promoting cartilage regeneration based on cxcl14
By using CXCL14 protein and its peptide fragments, along with stem cell-derived extracellular vesicles, the problem of regeneration difficulties in the treatment of cartilage damage was solved, achieving effective cartilage differentiation and repair, and improving the symptoms of degenerative osteoarthritis.
CN122249225APending Publication Date: 2026-06-19FAR EASTERN MEMORIAL HOSPITAL
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- FAR EASTERN MEMORIAL HOSPITAL
- Filing Date
- 2024-09-06
- Publication Date
- 2026-06-19
AI Technical Summary
⚠Technical Problem
Existing treatments for cartilage damage are ineffective in promoting cartilage regeneration and cannot completely prevent progressive joint destruction or cure osteoarthritis.
⚗Method used
By utilizing CXCL14 protein and its peptide fragments, a pharmaceutical composition containing a therapeutically effective amount of CXCL14 protein or its peptide fragments and a pharmaceutically acceptable carrier is prepared, which is then combined with stem cell-derived extracellular vesicles (EVs) to promote cartilage regeneration.
🎯Benefits of technology
It significantly promoted cartilage differentiation and repair, reduced joint swelling, improved cartilage function, and reduced the symptoms of osteoarthritis.
✦ Generated by Eureka AI based on patent content.
Abstract
The present invention discloses a method and pharmaceutical composition for cartilage regeneration or treatment of cartilage defects such as osteoarthritis, comprising CXCL14 protein or a peptide fragment thereof. The method and pharmaceutical composition may further comprise extracellular vesicles derived from stem cells.
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