Diagnostic system for differentiating bacterial and viral infections using myxovirus resistance protein a and c-reactive protein

CN122249714APending Publication Date: 2026-06-19BODITECHMED INC

Patent Information

Authority / Receiving Office: CN · China
Patent Type: Applications(China)
Current Assignee / Owner: BODITECHMED INC
Filing Date: 2024-09-26
Publication Date: 2026-06-19

AI Technical Summary

Technical Problem

Existing diagnostic methods for viral and bacterial infections have limitations in personalized diagnosis. Qualitative methods cannot accurately distinguish between viral and bacterial infections, especially in cases of mixed infections, making it difficult to make the right decision.

Method used

By measuring blood levels of myxovirus resistance protein (MxA) and C-reactive protein (CRP) and using their ratio and cutoff values, an algorithm was developed to distinguish between viral and bacterial infections. Diagnostic performance was optimized by combining logistic regression analysis and ROC curves.

Benefits of technology

It achieves highly accurate differentiation between viral and bacterial acute respiratory diseases in the emergency room, significantly reduces unnecessary antibiotic use, and improves diagnostic sensitivity and specificity, especially in the prediction of bacterial infections, reaching over 90%.

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Abstract

A diagnostic system for differentiating bacterial and viral infections using myxovirus resistance proteins A and C-reactive proteins is characterized by detecting antibodies that bind to antigens in a blood sample to form antigen-antibody complexes, and these antigen-antibody complexes are captured by other antibodies immobilized on a test strip as they move to a nitrocellulose matrix, allowing for the quantitative detection of MxA and CRP levels in the blood sample.

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