A traditional Chinese medicine composition with analgesic effect, external preparation and preparation method thereof

Abstract

The application belongs to the technical field of traditional Chinese medicines, specifically to the technical field of Miao medicine, and more specifically to a traditional Chinese medicine composition with analgesic effect, an external preparation thereof and a preparation method. The traditional Chinese medicine composition is composed of the following raw medicinal materials in parts by weight: Tongguuxiang 260-340, Heiguteng 160-240, Jianghuang 160-240, Danggui 130-170, Qingfengteng 130-170, Yinyanghuo 80-120, Sibukaowa 80-120, the external preparation is processed by weighing, crushing, mixing, coating, slicing, pasting and packaging, and the traditional Chinese medicine composition or the external preparation can significantly treat or improve the pain symptoms of diseases such as rheumatism, cervical spondylosis and lumbago, and has the characteristics of significant curative effect and quick effect.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, specifically to the field of Miao medicine technology, and more specifically to a traditional Chinese medicine composition with analgesic effects, its external preparation and preparation method. Background Technology

[0002] Miao medicine has unique theories on the etiology, pathogenesis, and treatment principles for muscle and bone pain. Miao medicine believes that "no disease arises without toxins, and no illness develops without disorder," with the root cause of pain lying in the invasion of external toxins or the accumulation of internal toxins. External toxins include wind toxins, cold toxins, and dampness toxins. For example, wind toxins can cause migratory pain or lightning-like stabbing pain, while cold toxins can cause localized cold pain that worsens with exposure to cold. Internal toxins cause pain due to abnormal circulation of qi, blood, and fluids, leading to stagnation and blood stasis. This emphasizes that obstruction of qi, blood, and fluids in the "muscles and meridians" is the direct cause of pain. The main treatment principle is to remove toxins, unblock the meridians, and harmonize qi and blood. External treatments for pain are characteristic therapies of Miao medicine, such as crossbow needle therapy, moxibustion with medicated paper, Miao medicinal baths, and plasters.

[0003] Miao medicine believes that modern diseases such as rheumatoid arthritis, lower back pain, and frozen shoulder share similar or identical etiologies and pathogenesis in their pain symptoms. Miao medicine can be used for effective treatment, and this has proven effective in practice. Rheumatoid arthritis (Gaojiachong) is often caused by weak constitution, old age, living in damp environments, or invasion of wind, cold, dampness, heat, and toxins into the body. Symptoms include blocked meridians, pain, numbness, soreness, and swelling. Over time, this damages blood and qi, leading to joint swelling and pain. Lower back pain (Gadiumeng) is often caused by wind, cold, dampness, external injuries, and overexertion. This leads to blood stagnation and qi stagnation, disrupting the flow of qi and blood, obstructing the meridians, and causing soreness, swelling, pain, numbness, and even difficulty in extending and flexing muscles, tendons, joints, and the lower back and legs. Frozen shoulder (also known as adhesive capsulitis) is caused by wind, cold and dampness invading the painful area, obstructing the flow of qi and blood, causing qi stagnation and blood stasis, and resulting in malnourishment of the painful area. The main symptoms are shoulder joint pain, muscle weakness and limited range of motion.

[0004] In existing techniques, Huang Ying et al. used the Miao medicine Wuteng San external application, either in combination with or without Western medicine, to treat cold-dampness type rheumatoid arthritis. The results showed that the external application of Wuteng San could alleviate clinical symptoms such as morning stiffness and joint pain in patients with rheumatoid arthritis. Hu Hong divided 64 patients with rheumatoid arthritis into a control group and an observation group. The control group received Western medicine treatment and routine nursing care, while the observation group received external application of Miao medicine. The results showed that the observation group showed better improvement in pain levels than the control group.

[0005] In existing technologies, Hu Jianshan et al. conducted a randomized controlled study on the analgesic effect of the Miao medicine chicken embryo earthworm ointment on acute low back pain. The results showed that the ointment could significantly reduce the pain of patients with acute low back pain, with rapid onset of action, safety, and no toxic side effects. However, this Miao medicine preparation has been found to have problems such as short storage time and insignificant efficacy in clinical use.

[0006] In the prior art, CN104000920A discloses a Miao medicine preparation for treating pain or arthralgia, characterized in that it is prepared from the following Chinese medicinal materials: 100-200g of *Hedyotis diffusa*, 100-200g of *Ulmus pumila*, 70-150g of *Gynostemma pentaphyllum*, 70-150g of *Euphorbia hirta*, 70-150g of *Euphorbia hirta*, 70-150g of camphor root, 70-150g of *Cinnamomum camphora*, 5-20g of *Artemisia argyi*, plus 10-30g of Sichuan pepper oil, 70-150g of polyvinyl methyl aldehyde, and 20-50ml of 75% ethanol. It has the effects of dispelling wind and dampness, clearing the meridians, and relieving pain. However, in clinical use, this Miao medicine preparation has been found to have problems such as short duration of efficacy and insignificant analgesic effect.

[0007] As mentioned above, in the practice of Miao medicine, the applicant found that the above-mentioned Miao medicine external patches have problems such as slow onset of action and insignificant efficacy when treating pain symptoms such as rheumatoid arthritis, back pain, and frozen shoulder. There is a technical need to find a Miao medicine external pain relief patch with significant efficacy and fast onset of action. Summary of the Invention

[0008] The purpose of this invention is to provide a traditional Chinese medicine composition with analgesic effect, its external preparation and preparation method, which has the characteristics of significant efficacy and rapid onset of action, and can effectively improve or relieve pain symptoms such as rheumatoid arthritis, back pain, and frozen shoulder.

[0009] The technical solution of the present invention: A traditional Chinese medicine composition with analgesic effect, comprising the following raw materials by weight: 260-340 parts of *Clematis chinensis*, 160-240 parts of *Gynostemma pentaphyllum*, 160-240 parts of turmeric, 130-170 parts of *Angelica sinensis*, 130-170 parts of *Sinomenium acutum*, 80-120 parts of *Epimedium brevicornu*, and 80-120 parts of *Symplocos buergerianum*.

[0010] Furthermore, the traditional Chinese medicine composition comprises the following raw materials by weight: 270-330 parts of *Clematis chinensis*, 170-230 parts of *Gynostemma pentaphyllum*, 170-230 parts of turmeric, 140-160 parts of *Angelica sinensis*, 140-160 parts of *Sinomenium acutum*, 90-110 parts of *Epimedium brevicornu*, and 90-110 parts of *Symplocos buergerianum*.

[0011] Furthermore, the traditional Chinese medicine composition comprises the following raw materials by weight: 280-320 parts of *Clematis chinensis*, 180-220 parts of *Gynostemma pentaphyllum*, 180-220 parts of turmeric, 140-160 parts of *Angelica sinensis*, 140-160 parts of *Sinomenium acutum*, 90-110 parts of *Epimedium brevicornu*, and 90-110 parts of *Symplocos buergerianum*.

[0012] Furthermore, the traditional Chinese medicine composition comprises the following raw materials by weight: 290-310 parts of *Clematis chinensis*, 190-210 parts of *Gynostemma pentaphyllum*, 190-210 parts of turmeric, 140-160 parts of *Angelica sinensis*, 140-160 parts of *Sinomenium acutum*, 90-110 parts of *Epimedium brevicornu*, and 90-110 parts of *Symplocos buergerianum*.

[0013] Preferably, the traditional Chinese medicine composition is composed of the following raw materials in parts by weight: 300 parts of *Clematis chinensis*, 200 parts of *Gynostemma pentaphyllum*, 200 parts of turmeric, 150 parts of *Angelica sinensis*, 150 parts of *Sinomenium acutum*, 100 parts of *Epimedium brevicornu*, and 100 parts of *Symplocos buergerianum*.

[0014] The present invention also provides a topical preparation of a traditional Chinese medicine composition with analgesic effect, which is made from the aforementioned traditional Chinese medicine composition with analgesic effect or its extract and pharmaceutically permissible excipients; the dosage form of the preparation includes patches and ointments.

[0015] The extract is an aqueous extract.

[0016] The preparation method of the formulation is any one of the following methods: Method 1: Weigh the raw material, pulverize it, mix it well, add the excipients and mix well to obtain the final product; Method 2: Weigh the raw materials, mix them, extract them, add excipients to the extract and mix well to obtain the final product.

[0017] Furthermore, the patch is prepared using any of the following methods: Method 1: Weigh the raw material, crush it, mix it, add the excipients and mix it again, then proceed with the process of applying the paste, slicing, applying the dressing, and packaging to obtain the final product. Method 2: Weigh the raw materials, mix them, extract them, add excipients to the extract and mix well. Then, apply the mixture as an ointment, slice it, apply it to a cloth, and package it to obtain the final product.

[0018] Further, by weight, the excipients consist of: 250-350 parts sesame oil, 450-550 parts yellow petrolatum, 350-450 parts lanolin, 550-650 parts beeswax, and 50-150 parts medicinal charcoal.

[0019] Furthermore, by weight, the excipients consist of: 280-320 parts sesame oil, 480-520 parts yellow petrolatum, 380-420 parts lanolin, 580-620 parts beeswax, and 80-120 parts medicinal charcoal.

[0020] Furthermore, by weight, the excipients consist of: 300 parts sesame oil, 500 parts yellow petrolatum, 400 parts lanolin, 600 parts beeswax, and 100 parts medicinal charcoal.

[0021] The traditional Chinese medicine composition of the present invention is a topical medicine, and the effects of each raw material are as follows: The main effects of Touguxiang are to dispel wind and dampness, promote blood circulation and relieve pain, dispel cold and unblock the meridians. It is suitable for rheumatic joint pain, sprains and bruises and other diseases.

[0022] Black bone vine's main effects are to relax muscles and promote blood circulation, dispel wind and dampness, and it is suitable for rheumatic pain, etc.

[0023] Turmeric's main functions are to promote blood circulation, regulate qi, and relieve pain. It is suitable for arm pain, abdominal masses, injuries from falls, and carbuncles.

[0024] Angelica sinensis has the main functions of nourishing blood and promoting blood circulation, regulating menstruation and relieving pain, and moistening the intestines and relieving constipation. It is suitable for abdominal pain due to deficiency and cold, rheumatic pain, and injuries from falls.

[0025] The main effects of Qingfengteng are to dispel wind and dampness, clear the meridians, and promote urination. It is suitable for rheumatic pain, joint swelling, numbness and itching.

[0026] Epimedium, whose main functions are to tonify the kidneys and strengthen yang, strengthen muscles and bones, and dispel wind and dampness, is often used to treat symptoms such as impotence and soreness of the waist and knees.

[0027] Four tiles are mainly used for dispelling wind and dampness, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, and are often used to treat symptoms such as rheumatic pain and traumatic injuries.

[0028] Based on the principle of single-ingredient formulation and three-in-one formulation of Miao medicine, this invention scientifically selects the ingredients of three categories of medicines: lead medicine, supporting medicine, and monitoring medicine, and formulates them scientifically. The lead medicine is Touguxiang, the supporting medicines are Heiguteng, Jianghuang, Danggui, and Qingfengteng, and the monitoring medicines are Epimedium and Sikuaiwa.

[0029] This invention's herbal composition is based on the Miao people's experienced formulas for treating rheumatism, cervical spondylosis, and lower back pain, and is derived through clinical experience and innovative improvements. The formula embodies both the traditional characteristics of traditional Chinese medicine in treating arthralgia and incorporates practical experience from folk remedies. The prescription reflects the principles of traditional Chinese medicine in treating arthralgia, focusing on warming the meridians, dispelling cold, and eliminating wind and dampness. It also demonstrates the ethnic minority's characteristic use of aggressive methods in herbal medicine, believing that arthralgia, regardless of its cause, is due to stagnation of qi and blood, and obstruction of the meridians. Pain arises from blockage; therefore, "unblocking the obstruction" becomes another important principle in treating arthralgia. The herbs in the formula are commonly used in folk medicine for treating shoulder pain, possessing the effects of promoting blood circulation, removing blood stasis, tonifying the kidneys, dispelling wind and dampness, reducing swelling, and relieving pain. Furthermore, the inventors have innovatively discovered that pain symptoms such as rheumatoid arthritis, lower back pain, and frozen shoulder are not only closely related to internal and external toxins but are also influenced by qi, blood, and fluid. The kidneys' main physiological functions are storing essence, governing growth, development, and reproduction, regulating water metabolism, and controlling the intake of qi. They are also closely related to bones, marrow, and ears, significantly influencing the circulation of qi, blood, and fluids. For example, kidney deficiency occurs with age, leading to symptoms such as lower back pain, weak legs, dizziness, tinnitus, dry and brittle hair, premature graying, and constipation. The strength of kidney qi directly affects a person's growth, development, and even the entire aging process, as well as their reproductive capacity. In youth and middle age, kidney essence is abundant, even reaching its peak, resulting in a robust physique and strong bones and muscles. However, in old age, kidney essence declines, the body gradually ages, muscles and bones become less flexible, teeth loosen, and hair falls out, presenting a frail and aged appearance. Therefore, the inventors have innovatively used Epimedium as a guiding herb, which acts to guide the medicine to the kidneys and tonify them, fundamentally changing the problems of weak qi, blood, and fluids and their impaired circulation. When applied to the treatment of pain-related diseases such as rheumatism, cervical spondylosis, and lower back pain, clinical results show that, guided by the principles of treating the root cause and holistic treatment, it has achieved significant therapeutic effects and rapid onset of action.

[0030] The beneficial effects of this invention are: This invention combines Miao medicine theory with traditional Chinese medicine theory, that is, combining Miao medicine (black bone vine, bone-penetrating incense, green wind vine, four tiles) with traditional Chinese medicine (turmeric, angelica, epimedium). The combination or its preparation has the characteristics of significant efficacy and rapid effect, and can effectively improve or relieve pain symptoms such as rheumatoid arthritis, back pain, and frozen shoulder.

[0031] This invention selects *Clematis chinensis* as the lead herb (i.e., the principal herb), leveraging its effects of dispelling wind and dampness, promoting blood circulation and relieving pain, and dispersing cold and unblocking meridians. This results in a significantly improved overall prescription efficacy and a strong targeted approach to relieving dysentery and muscle and bone pain. Compared with the prescription in existing technology CN104000920A, which uses *Clematis chinensis* as the principal herb, this invention exhibits a significantly superior analgesic effect.

[0032] This invention innovatively uses Epimedium as a monitoring drug, which guides the medicine to the kidneys and tonifies the kidneys, fundamentally changing the problems of weak qi, blood and fluid and poor circulation, and achieving significant therapeutic effects and rapid onset of action.

[0033] The preparation method of the present invention can effectively ensure the content and activity of the active ingredients, and the quality is stable, uniform and controllable. Detailed Implementation

[0034] Example 1: A topical patch with analgesic effect has the following raw material formula: 300g of *Touguxiang*, 200g of *Heiguteng*, 200g of *Jianghuang*, 150g of *Danggui*, 150g of *Qingfengteng*, 100g of *Yinyanghuo*, and 100g of *Sikuaiwa*.

[0035] The preparation method is as follows: accurately weigh the raw materials according to the above formula, crush them, mix them, add excipients (i.e., 300g sesame oil, 500g yellow petrolatum, 400g lanolin, 600g beeswax, and 100g medicinal charcoal), mix them, apply the paste, cut them, apply them to the cloth, package them, and prepare them as patches.

[0036] Example 2: A topical patch with analgesic effect has the following raw material formula: 340g of *Clematis chinensis*, 240g of *Gynostemma pentaphyllum*, 240g of turmeric, 170g of *Angelica sinensis*, 130g of *Sinomenium acutum*, 80g of *Epimedium brevicornu*, and 80g of *Symplocos buergerianum*.

[0037] The preparation method is as follows: accurately weigh the raw materials according to the above formula, crush them, mix them evenly, add excipients (i.e., 250g sesame oil, 450g yellow petrolatum, 350g lanolin, 550g beeswax, and 150g medicinal charcoal) to prepare a patch.

[0038] Example 3: A topical patch with analgesic effect has the following raw material formula: 260g of *Touguxiang*, 160g of *Heiguteng*, 160g of *Jianghuang*, 130g of *Danggui*, 170g of *Qingfengteng*, 120g of *Yinyanghuo*, and 120g of *Sikuaiwa*.

[0039] The preparation method is as follows: accurately weigh the raw materials according to the above formula, crush them, mix them evenly, add excipients (i.e., 350g of sesame oil, 550g of yellow petrolatum, 450g of lanolin, 650g of beeswax, and 50g of medicinal charcoal) to prepare a patch.

[0040] Example 4: A topical patch with analgesic effect has the following raw material formula: 330g of *Touguxiang*, 230g of *Heiguteng*, 230g of *Jianghuang*, 140g of *Danggui*, 140g of *Qingfengteng*, 90g of *Yinyanghuo*, and 90g of *Sikuaiwa*.

[0041] The preparation method is as follows: accurately weigh the raw materials according to the above formula, mix them, decoct them in water to extract them, concentrate and dry the filtrate to obtain the extract, add excipients (i.e., 320g of sesame oil, 520g of yellow petrolatum, 420g of lanolin, 580g of beeswax, and 80g of medicinal charcoal) to prepare it as a patch.

[0042] Example 5: A topical patch with analgesic effect has the following raw material formula: 270g of *Touguxiang*, 170g of *Heiguteng*, 170g of *Jianghuang*, 160g of *Danggui*, 160g of *Qingfengteng*, 110g of *Yinyanghuo*, and 110g of *Sikuaiwa*.

[0043] The preparation method is as follows: accurately weigh the raw materials according to the above formula, mix them, decoct with 10 times the amount of water to extract, concentrate and dry the filtrate to obtain the extract, add excipients (280g sesame oil, 480g yellow petrolatum, 380g lanolin, 620g beeswax, 120g medicinal charcoal) to prepare a patch.

[0044] Example 6: A topical patch with analgesic effect has the following raw material formula: 320g of *Clematis chinensis*, 220g of *Gynostemma pentaphyllum*, 180g of turmeric, 140g of *Angelica sinensis*, 140g of *Sinomenium acutum*, 90g of *Epimedium brevicornu*, and 90g of *Symplocos buergerianum*. The preparation method is the same as in Example 1.

[0045] Example 7: A topical patch with analgesic effect has the following raw material formula: 280g of *Clematis chinensis*, 180g of *Gynostemma pentaphyllum*, 220g of turmeric, 160g of *Angelica sinensis*, 160g of *Sinomenium acutum*, 110g of *Epimedium brevicornu*, and 110g of *Symplocos buergerianum*. The preparation method and excipients are the same as in Example 1.

[0046] Example 8: A topical patch with analgesic effect has the following raw material formula: 310g of *Clematis chinensis*, 190g of *Gynostemma pentaphyllum*, 190g of turmeric, 140g of *Angelica sinensis*, 140g of *Sinomenium acutum*, 90g of *Epimedium brevicornu*, and 90g of *Symplocos buergerianum*. The preparation method and excipients are the same as in Example 1.

[0047] Example 9: A topical patch with analgesic effect has the following raw material formula: 290g of *Clematis chinensis*, 210g of *Gynostemma pentaphyllum*, 210g of turmeric, 160g of *Angelica sinensis*, 160g of *Sinomenium acutum*, 110g of *Epimedium brevicornu*, and 110g of *Symplocos buergerianum*. The preparation method and excipients are the same as in Example 1.

[0048] Comparative Example 1: (Lacking Epimedium compared to Example 1) A topical patch with analgesic effect has the following raw material formula: 300g of *Touguxiang*, 200g of *Heiguteng*, 200g of *Jianghuang*, 150g of *Danggui*, 150g of *Qingfengteng*, and 100g of *Sikuaiwa*.

[0049] The preparation method is: accurately weigh the active pharmaceutical ingredient according to the above formula, pulverize and mix uniformly, add the adjuvants (i.e. 300g sesame oil, 500g yellow petrolatum, 400g lanolin, 600g beeswax, 100g medicinal charcoal), mix uniformly, spread into a plaster, cut into slices, attach to backing fabric, and package to prepare the patch.

[0050] Comparative Example 2: (the Miao medicinal preparation of Example 1 in CN104000920A) Raw materials: 150g of Illigera rhodantha, 150g of Lysimachia paridiformis, 100g of Toddalia asiatica, 100g of Psammosilene tunicoides, 100g of Chloranthus holostegius, 100g of Cinnamomum porrectum root, 100g of Gaultheria leucocarpa, 15g of Borneolum Syntheticum, 20g of Zanthoxylum bungeanum oil, 100g of polyvinyl acetal, 30ml of 75% ethanol Preparation method: take the seven medicinal materials of Illigera rhodantha, Lysimachia paridiformis, Toddalia asiatica, Psammosilene tunicoides, Chloranthus holostegius, Cinnamomum porrectum root and Gaultheria leucocarpa, add 10 times the amount of water each time to carry out decoction and extraction for 3 times, 1 hour for each decoction, filter, combine the filtrates, concentrate under reduced pressure to a thick paste with a relative density of 1.12-1.16 (at 80°C), add ethanol to make the ethanol content of the medicinal liquid reach 75%; add polyvinyl acetal, add 75% ethanol for soaking and swelling until it is completely dissolved, stir well for later use; add Borneolum Syntheticum and Zanthoxylum bungeanum oil to the alcohol precipitation liquid, then fully stir and mix uniformly with the matrix, add 75% ethanol to adjust the total amount to 1000g, to obtain the product.

[0051] Experimental Example (Verification of Analgesic Effect) I. Experimental Materials 1. Experimental animals: SPF grade SD rats, male, weighing 180-220g, provided by the Laboratory Animal Center of Guizhou Medical University, Animal License No.: SCXK (Qian) 2022-0001.

[0052] 2. Test drugs: Blank group: Normal saline Model group: Normal saline Experimental group: Patch extract of Example 1 Control group 1: Patch extract of Comparative Example 1 (without Epimedium) Control group 2: Patch extract of Comparative Example 2 (CN104000920A) 3. Main instruments: Hot plate apparatus, electronic balance, rat fixator, etc.

[0053] II. Experimental Methods The rat acetic acid writhing analgesia experiment is adopted, with reference to *Methodology of Pharmacological Research of Traditional Chinese Medicine*.

[0054] 1. Acetic acid writhing experiment: Rats are randomly divided into 5 groups, 10 rats in each group, and administered continuously for 7 days. 30 minutes after the last administration, 0.2mL of 0.6% acetic acid solution is intraperitoneally injected per rat, the number of writhing times of the rats within 15 minutes is observed and recorded, and the analgesic rate is calculated.

[0055] Analgesia rate (%) = (Average number of writhing movements in the model group - Average number of writhing movements in the treatment group) / Average number of writhing movements in the model group × 100% III. Experimental Results 1. Results of the acetic acid writhing test (x±s)

[0056] Note: Compared with the control group, **P<0.01; compared with the model group, ##P<0.01.

[0057] It can be seen from the above table: 1. Compared with the model group, the experimental group, control group 1, and control group 2 all reduced the number of acetic acid-induced writhing episodes and had a significant analgesic effect.

[0058] 2. The analgesic effect of the experimental group (Example 1) was significantly better than that of the control group 1 (lacking Epimedium) and the control group 2 (existing technology), and the difference was statistically significant (P<0.01).

[0059] 3. The analgesic effect of the patch decreased significantly after the absence of Epimedium, proving that Epimedium plays a key role in enhancing the efficacy of this formula.

[0060] 4. The patch of this invention has a rapid onset of action and a long-lasting effect, and its analgesic effect is significantly better than that of existing Miao medicine patches, which verifies the scientific nature and superiority of the formula of this invention.

Claims

1. A topical patch with analgesic effect, characterized in that, The analgesic topical patch is made from a traditional Chinese medicine composition or its extract with analgesic effects and pharmaceutically permissible excipients; the traditional Chinese medicine composition consists of the following raw materials in parts by weight. Composition: 290-310 parts of *Clematis chinensis*, 190-210 parts of *Gynostemma pentaphyllum*, 190-210 parts of turmeric, 140-160 parts of angelica sinensis, 140-160 parts of *Sinomenium acutum*, 90-110 parts of *Epimedium brevicornu*, and 90-110 parts of *Symplocos buergerianum*, with *Clematis chinensis* as the lead ingredient.

2. The topical patch with analgesic effect as described in claim 1, characterized in that, The traditional Chinese medicine composition comprises, by weight, the following raw materials. Composition: 300 parts of *Clematis chinensis*, 200 parts of *Gynostemma pentaphyllum*, 200 parts of turmeric, 150 parts of angelica sinensis, 150 parts of *Sinomenium acutum*, 100 parts of *Epimedium brevicornu*, and 100 parts of *Symplocos sipatica*.

3. A method for preparing a topical patch with analgesic effect as described in claim 1 or 2, characterized in that, It is made by any of the following methods: Method 1: Weigh the raw material, crush it, mix it, add the excipients and mix it again, then proceed with the process of applying the paste, slicing, applying the dressing, and packaging to obtain the final product. Method 2: Weigh the raw materials, mix them, extract them, add excipients to the extract and mix well. Then, apply the mixture as an ointment, slice it, apply it to a cloth, and package it to obtain the final product.

4. The method for preparing a topical patch with analgesic effect as described in claim 3, characterized in that, The excipients, by weight, consist of: 250-350 parts sesame oil, 450-550 parts yellow petrolatum, 350-450 parts lanolin, 550-650 parts beeswax, and 50-150 parts medicinal charcoal.

5. The method for preparing a topical patch with analgesic effect as described in claim 4, characterized in that, The excipients, by weight, consist of: 280-320 parts sesame oil, 480-520 parts yellow petrolatum, 380-420 parts lanolin, 580-620 parts beeswax, and 80-120 parts medicinal charcoal.

6. The method for preparing a topical patch with analgesic effect as described in claim 5, characterized in that, The excipients, by weight, consist of: 300 parts sesame oil, 500 parts yellow petrolatum, 400 parts lanolin, 600 parts beeswax, and 100 parts medicinal charcoal.

Images