A bio-printing and high-throughput drug screening integrated work platform and method thereof

Abstract

The application discloses a kind of biological printing and high-throughput drug screening integrated work platform and method thereof, the platform includes three-axis mechanical arm movement platform, automatic pipette gun, translation gripper, electron microscope and piezoelectric printing valve;Three-axis platform adopts double-Y-axis three-Z-axis layout, and different functional modules are respectively carried on two sides;Modularization fixed consumables, well plate, reagent and other modules on the object carrying bottom plate.Piezoelectric printing valve integrates piezoelectric drive striker structure, micro sample introduction system and temperature control cold box with serpentine flow channel.Based on the precision printing of specific unipolar square wave parameters;Utilize microscopic visual feedback to judge the preset pattern to reach the preset curing standard and automatically add medicine;And high-throughput drug screening detection.The application solves the problems of low printing precision, poor cell activity and low multi-process synergistic efficiency when processing temperature-sensitive and high-viscosity biological materials in the prior art, realizes low-cost, high-consistency and high-throughput automation of in-vitro culture manufacturing, and significantly improves the efficiency and reliability of drug screening.

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