Enterprise human health risk assessment calculation method and system

Abstract

The present application relates to the technical field of human health risk assessment, and discloses an enterprise human health risk assessment calculation method and system. The method combines occupational health risk assessment and environmental health risk assessment, supplements the exposure pathways under the two systems, proposes to calculate the human health risk level of the inhalation pathway by using the occupational health detection results of chemical harmful factors, improves the accuracy and comprehensiveness of risk assessment calculation, thereby providing guidance for the implementation of health protection measures such as personal protective equipment, and protecting the physical health of employees in production enterprises.

Description

Technical Field

[0001] This invention relates to the field of human health risk assessment technology, and discloses a method and system for calculating human health risk assessment for enterprises. Background Technology

[0002] For enterprises in operation, if soil and groundwater exceed the standards

[10]

[17] , long-term exposure to pollution will pose a health risk to employees. For the assessment of this risk, the current domestic reference is the parameters, pathways and calculation methods in the "Technical Guidelines for Risk Assessment of Soil Pollution in Construction Land" (HJ 25.3-2019). The human health risk exposure pathways of soil and groundwater include oral ingestion of soil, skin contact with soil, inhalation of soil particles, inhalation of gaseous pollutants from soil and groundwater in outdoor / indoor air and drinking groundwater.

[0003] Meanwhile, some chemicals present or generated in the workplace can pose occupational health risks to employees. There are many methods for occupational health risk assessment, including qualitative, semi-quantitative, and quantitative assessments. Numerous scholars have compared and studied different occupational health risk assessment methods. Based on these studies, quantitative assessments of occupational health risks currently all refer to the same model: the inhalation model from the U.S. Environmental Protection Agency (USEPA).

[0004] For operating enterprises, both of these human health risks coexist. However, currently, occupational health is managed by the National Health Commission, while soil and groundwater pollution in operating enterprises and the resulting human health risks are managed by the environmental protection department. Generally, neither is considered comprehensively. Therefore, there is an urgent need for a method for assessing and calculating enterprise human health risks that can comprehensively consider occupational and environmental health risks and supplement and quantify multi-media exposure pathways. Summary of the Invention

[0005] To address the above issues, this invention combines occupational health and human health risk assessment to provide a method and system for calculating enterprise human health risk. It optimizes the accuracy and comprehensiveness of risk level calculation, thereby providing guidance for the implementation of health protection measures such as personal protective equipment and protecting the health of employees in production enterprises.

[0006] To achieve the above objectives, the present invention specifically adopts the following solution: A method for calculating corporate human health risk assessment includes the following steps: S1: Based on the occupational hazard factor detection and evaluation report, identify the areas, positions, and harmful chemical factors with occupational health risks, and clarify their acute and chronic / subchronic health risks; S2: Based on the enterprise's self-monitoring report and soil and groundwater environmental survey data, identify key monitoring units for soil and groundwater, characteristic pollutants of the enterprise, and calculate the detection concentration of each detection factor in soil and groundwater samples; S3: Compile the hazardous chemical factors with chronic / subchronic health risks in occupational health testing reports, as well as the factors detected in soil and groundwater surveys; compare the differences between hazardous chemical factors in the workplace and the factors detected in soil and groundwater, and conduct supplementary testing for the differential factors; S4: Based on the layout plan of the production enterprises, key monitoring units for soil and groundwater and areas with hazardous chemical factors in the workplace are divided, the spatial overlap between the two is determined, and they are divided into three types of areas. S5: For the three types of areas, list all possible exposure routes and include skin contact with chemicals and skin contact with groundwater in the exposure route system; S6: For areas that are key monitoring units for soil and groundwater and have workplace hazardous chemical factors, the human health risk of gaseous hazardous factors / pollutants under the inhalation route shall be recalculated using the concentration of hazardous chemical factors in the air obtained from occupational health monitoring. S7: If there are exposure routes such as skin contact with chemicals or skin contact with groundwater, quantify the exposure amount and calculate the corresponding human health risk level. S8: Based on the company's actual production situation, site conditions, and job characteristics, screen the actual exposure pathways in each area and perform risk characterization calculations; for the same chemical substance, compare its carcinogenic risk calculation results with 10 -4 Comparisons are made to determine whether the carcinogenic risk is acceptable; S9: Based on the combined results of occupational health testing and soil and groundwater surveys, analyze the overall carcinogenic risk and non-carcinogenic hazard quotient of human health under various exposure routes, identify areas with unacceptable risks and harmful factors, and propose corresponding risk management or health protection measures.

[0007] Furthermore, the specific division of the three region types mentioned in step S4 is as follows: 1) Type 1: There are only chemical hazards in the workplace, but it does not belong to the key monitoring units for soil and groundwater; 2) The second type: It belongs to the key monitoring unit for soil and groundwater, but there are no workplace chemical hazards; 3) The third type: It belongs to the key monitoring unit for soil and groundwater and there are chemical hazards in the workplace.

[0008] Furthermore, step S5, based on the three region types, specifically includes the following possible exposure pathways: 1) The first type of possible exposure routes include: ① skin contact with chemicals; ② inhalation of harmful chemicals (including indoor and outdoor work positions); 2) The second type of possible exposure routes include: ① oral ingestion of soil; ② skin contact with soil; ③ inhalation of soil particulate matter; ④ inhalation of gaseous pollutants from the top layer of soil in outdoor air; ⑤ inhalation of gaseous pollutants from the lower layer of soil in outdoor air; ⑥ inhalation of gaseous pollutants from the lower layer of soil in indoor air; ⑦ inhalation of gaseous pollutants from groundwater in outdoor air; ⑧ inhalation of gaseous pollutants from groundwater in indoor air; ⑨ drinking groundwater; ⑩ skin contact with groundwater. 3) The third type of possible exposure routes include: ① oral ingestion of soil; ② skin contact with soil; ③ skin contact with chemicals; ④ inhalation of soil particles; ⑤ inhalation of harmful chemicals (including outdoor air from topsoil, outdoor air from lower soil, indoor air from lower soil, outdoor air from groundwater, indoor air from groundwater, and harmful chemical factors in indoor and outdoor workplaces with occupational health risks); ⑥ drinking groundwater; ⑦ skin contact with groundwater.

[0009] Furthermore, in step S6, for the third type of area, the exposure concentration of hazardous chemicals in the air obtained from occupational health testing is used to calculate the exposure concentration for employees in relevant positions, and the human health risk under the inhalation route is recalculated accordingly; the calculation formulas for carcinogenic risk and non-carcinogenic hazard quotient are as follows:

[0010]

[0011] In the formula: HQ is the non-carcinogenic hazard quotient; IR is the carcinogenic risk; CA is the concentration of hazardous chemicals in the air, μg / m3; ET is the daily exposure time, h / d; EF is the daily exposure frequency, d / a; ED is the exposure duration, a; Rfc is the reference exposure concentration; AT is the average exposure time (ED×365 d / a×24 h / d), h; IUR is the inhalation unit risk, (μg / m3)⁻¹; tE is the exposure duration, a; tL is the lifetime expectancy, a.

[0012] Furthermore, in step S7, the following formula is used to conduct a quantitative risk assessment for exposure routes of skin contact with chemicals and skin contact with contaminants in groundwater:

[0013]

[0014] In the formula: HQ is the non-carcinogenic hazard quotient; CR is the carcinogenic risk; SAE is the exposed skin surface area, cm2; EF is the exposure frequency, d / a; ED is the exposure period, a; EV is the frequency of skin contact events, times / d; DA is the skin contact absorbed dose, mg / cm2; BW is body weight, kg; ATnc is the mean time of non-carcinogenic effect, d; ATca is the mean time of carcinogenic effect, d; RfDd is the skin contact reference dose, mg / (kg·d); SFd is the skin contact carcinogenicity slope factor, mg / (kg·d). in: The formula for calculating the DA of inorganic substances is as follows:

[0015] The formula for calculating the DA of organic matter is as follows:

[0016]

[0017] Kp is the skin permeability coefficient, cm / h; C is the concentration of pollutants in groundwater or the concentration of chemicals in skin contact, mg / L; tevent is the time of each skin contact, h; FA is the water absorption rate, dimensionless; τevent is the hysteresis period of each contact, h / contact; t* is the steady-state arrival time, h; B is the ratio of the stratum corneum to the active epidermis permeability coefficient, dimensionless.

[0018] Correspondingly, the present invention also provides an enterprise human health risk assessment calculation system for implementing the above methods, including: The data acquisition module is used to acquire occupational health testing data and soil and groundwater environmental survey data of the target enterprise. The area division module, connected to the data acquisition module, is used to divide the key soil and groundwater monitoring modules and the areas with workplace chemical hazards according to the enterprise layout plan, and to determine the spatial overlap between the two. An exposure pathway identification module is connected to the area division module and is used to identify possible exposure pathways in each area based on the area division results, and to include skin contact with chemicals and skin contact with groundwater in the exposure pathway system. The risk assessment module, connected to the exposure pathway identification module, is used to calculate the comprehensive carcinogenic risk and non-carcinogenic hazard quotient of human health based on the identified exposure pathways, combined with occupational health monitoring data and soil and groundwater environmental survey data, and output the risk assessment results.

[0019] Furthermore, the risk assessment module includes: The inhalation risk calculation subunit is used to calculate the human health risk via inhalation based on occupational health monitoring data in areas where workplace chemical hazards exist. The skin contact risk calculation subunit is used to quantify the exposure amount and calculate the corresponding human health risk level when there are exposure routes such as skin contact with chemicals or skin contact with groundwater. The comprehensive risk characterization subunit, connected to the inhalation risk calculation subunit and the skin contact risk calculation subunit, is used to integrate risks from various routes, calculate the comprehensive carcinogenic risk and non-carcinogenic hazard quotient, compare it with a preset threshold, and output the areas and harmful factors where the risk is unacceptable.

[0020] Correspondingly, the present invention also provides an electronic device, including a memory, a processor, and a computer program stored in the memory and executable on the processor, wherein the processor executes the program to implement the steps of the enterprise human health risk assessment calculation method. Correspondingly, the present invention also provides a non-transitory computer-readable storage medium storing a computer program thereon, which, when executed by a processor, implements the steps of a method for calculating enterprise human health risk assessment.

[0021] Compared with the prior art, the present invention has the following beneficial technical effects: (1) Taking into account the location relationship between key monitoring units of soil and groundwater and areas with chemical hazards in the workplace, it helps to improve enterprises’ comprehensive understanding of occupational health and environment and improve their corresponding management level.

[0022] (2) Regarding the exposure routes, the two routes of skin contact with pollutants in groundwater and skin contact with chemicals were taken into consideration, which supplemented the quantification of these two routes in the human health risk assessment. At the same time, based on the spatial relationship between environmental risk and occupational health risk, the exposure routes of human health were comprehensively screened, which improved the calculation of human health risk level. (3) In areas where occupational health and environmental risks overlap, the concentration of hazardous chemical factors in the air obtained from occupational health testing is used to calculate the exposure concentration of employees in relevant positions. Based on the calculated exposure concentration, the carcinogenic risk and non-carcinogenic hazard quotient of each factor are calculated. The calculation results are comprehensive and avoid the simulation process of pollutant migration and diffusion in soil / groundwater. It is relatively simple and accurate. (4) Combining occupational health test results and soil and groundwater survey results, the comprehensive risk to human health under each exposure route is analyzed, and the results are more accurate, comprehensive and targeted. Detailed Implementation

[0023] The following describes the solutions in the embodiments of the present invention in full, with reference to specific examples. A method for calculating enterprise human health risk assessment includes the following steps: (1) Based on the occupational hazard factor detection and evaluation report, identify the areas, positions, harmful chemical factors and their acute, chronic / subchronic health risks that pose occupational health risks; (2) Based on the results of soil and groundwater surveys, such as the enterprise's self-monitoring report, sort out the key monitoring units for soil and groundwater, the characteristic pollutants of the enterprise, and the detection concentrations of various detection factors in the soil and groundwater surveys; (3) Compile statistics on chemical hazards present in occupational health testing reports that pose chronic / subchronic health risks, as well as the detected factors in soil and groundwater testing results. Compare the differences in chemical hazards in the workplace and the detected factors in soil and groundwater, and conduct supplementary testing for these factors; (4) Based on the layout plan of the production enterprises, divide the key monitoring units of soil and groundwater and the areas where there are chemical hazards in the workplace, determine their spatial relationship, and divide them into three types of areas based on their spatial overlap.

[0024] 1) Type 1: There are only chemical hazards in the workplace, but it does not belong to the key monitoring units for soil and groundwater; 2) The second type: It belongs to the key monitoring unit for soil and groundwater, but there are no workplace chemical hazards; 3) The third type: It belongs to the key monitoring unit for soil and groundwater and there are chemical hazards in the workplace.

[0025] (5) List all possible exposure routes in the three types of areas respectively. Include skin contact with chemicals and skin contact with groundwater as possible exposure routes.

[0026] Based on the locational relationship between key soil and groundwater monitoring units and areas with workplace chemical hazards, the following are all possible exposure pathways in the three types of areas: 1) The possible exposure routes for the first type include: ① skin contact with chemicals, ② inhalation of harmful chemicals (indoor and outdoor work in relevant positions).

[0027] 2) The second type of possible exposure includes the following routes: ① oral ingestion of soil, ② skin contact with soil, ③ inhalation of soil particulate matter, ④ inhalation of gaseous pollutants from the top layer of soil in outdoor air, ⑤ inhalation of gaseous pollutants from the lower layer of soil in outdoor air, ⑥ inhalation of gaseous pollutants from the lower layer of soil in indoor air, ⑦ inhalation of gaseous pollutants from groundwater in outdoor air, ⑧ inhalation of gaseous pollutants from groundwater in indoor air, ⑨ drinking groundwater, and ⑩ skin contact with groundwater.

[0028] 3) The third type of possible exposure routes include: ① oral ingestion of soil, ② skin contact with soil, ③ skin contact with chemicals, ④ inhalation of soil particles, ⑤ inhalation of harmful chemicals (from outdoor air from topsoil, outdoor air from lower soil, indoor air from lower soil, outdoor air from groundwater, indoor air from groundwater, indoor workplaces with occupational health risks, outdoor workplaces with occupational health risks, ⑥ drinking groundwater and ⑦ skin contact with groundwater.

[0029] (6) In key monitoring units for soil and groundwater where workplace chemical hazards exist, the human health risk from inhaling gaseous hazardous factors / pollutants is recalculated using the concentration of airborne chemical hazards detected by occupational health testing. The formulas for calculating the carcinogenic risk and non-carcinogenic hazard quotient are as follows:

[0030]

[0031] In the formula: HQ is the non-carcinogenic hazard quotient; IR is the carcinogenic risk; CA is the concentration of hazardous chemicals in the air, in μg / m³. 3 ET is the daily exposure time, h / d; EF is the daily exposure frequency, d / a; ED is the exposure duration, a; Rfc is the reference exposure concentration; AT is the average exposure time (ED × 365 d / a × 24 h / d), h; IUR is the inhalation unit risk, (μg / m³). 3 ) -1 ;t E To determine the length of service, a; t L a represents lifetime life expectancy.

[0032] (7) If there are two exposure routes, namely skin contact with chemicals and skin contact with groundwater, quantify the exposure amount and calculate the human health risk level. The formula for the quantitative risk assessment is as follows:

[0033]

[0034] In the formula: HQ stands for non-carcinogenic hazard quotient; CR stands for carcinogenic risk; SAE stands for exposed skin surface area, in cm². 2 EF is the exposure frequency, days per year; ED is the exposure period, years; EV is the frequency of skin contact events, times per day; DA is the absorbed dose through skin contact, mg / cm³. 2 BW represents body weight, in kg; AT ncMean time of non-carcinogenic effect, d; AT ca The mean time to carcinogenic effect, d; RfD d For skin contact reference dose, mg / (kg·d); SF d The carcinogenicity rate factor for skin contact is mg / (kg·d).

[0035] in: The formula for calculating the DA of inorganic substances is as follows:

[0036] The formula for calculating the DA of organic matter is as follows:

[0037]

[0038] K p C represents the skin permeability coefficient, in cm / h; C represents the concentration of pollutants in groundwater, or the concentration of chemicals in skin contact, in mg / L; t event τ represents the duration of each skin contact, in hours (h); FA represents the water absorption rate, dimensionless; τ event t* represents the hysteresis interval per contact, in hours (h / contact); t* represents the steady-state arrival time, in hours (h); B represents the ratio of the permeability coefficients of the stratum corneum to the active epidermis, dimensionless.

[0039] (8) Based on the actual production situation, site conditions, and job characteristics of the enterprise, screen the actual exposure routes in each area and perform risk characterization calculations. For the same substance, the carcinogenic risk calculated in the final risk assessment is compared with 10 -4 The results were compared to determine whether the carcinogenic risk was acceptable.

[0040] (9) Based on the results of occupational health testing and soil and groundwater surveys, analyze the comprehensive carcinogenic risk and non-carcinogenic hazard quotient of human health under each exposure route, screen out areas and harmful factors with unacceptable risks, and take corresponding risk control or health protection measures.

[0041] This embodiment provides a corporate human health risk assessment calculation system to implement the corporate human health risk assessment calculation method described in the above-described method embodiments. The system includes a data acquisition module, a region division module, an exposure pathway identification module, and a risk assessment module.

[0042] The data acquisition module is used to acquire occupational health monitoring data and soil and groundwater environmental survey data from the target enterprise. Specifically, this module extracts relevant data from documents such as occupational hazard factor monitoring reports, evaluation reports, and enterprise self-monitoring reports, including but not limited to information on areas with occupational health risks, job positions, chemical hazardous factors and their concentrations, key monitoring units for soil and groundwater, characteristic pollutants and their detection concentrations, etc.

[0043] The area segmentation module, connected to the data acquisition module, is used to segment key monitoring units for soil and groundwater and areas with workplace chemical hazards based on the company's site plan, and to determine the spatial overlap between the two. This module performs spatial analysis based on the company's site plan, classifying areas into types such as those containing only workplace chemical hazards, those belonging solely to key monitoring units for soil and groundwater, and those where both overlap and coexist, providing a foundation for subsequent exposure pathway identification.

[0044] The exposure pathway identification module, connected to the region segmentation module, identifies potential exposure pathways in each region based on the region segmentation results, and includes skin contact with chemicals and skin contact with groundwater in the exposure pathway system. This module has a pre-installed database of exposure pathways corresponding to region types, and can automatically match and generate a list of exposure pathways for each region, ensuring the comprehensiveness and accuracy of the exposure pathways.

[0045] The risk assessment module, connected to the exposure route identification module, is used to calculate the comprehensive carcinogenic risk and non-carcinogenic hazard quotient for human health based on the identified exposure routes, combined with occupational health monitoring data and soil and groundwater environmental survey data, and outputs the risk assessment results. This module further includes: The inhalation risk calculation subunit is used to calculate the human health risk via inhalation in areas where there are workplace chemical hazards, based on the concentration of airborne chemical hazards in occupational health monitoring data. The skin contact risk calculation subunit is used to quantify the exposure amount and calculate the human health risk level based on relevant data when there are exposure routes such as skin contact with chemicals or skin contact with groundwater. The integrated risk characterization subunit, connected to the inhalation risk calculation subunit and the skin contact risk calculation subunit, is used to integrate risks from various routes, calculate the integrated carcinogenic risk and non-carcinogenic hazard quotient, and compare it with a preset threshold (such as a carcinogenic risk of 10). -4 The system compares these findings, identifies areas and harmful factors where risks are unacceptable, and proposes corresponding risk management or health protection measures.

[0046] This system achieves a comprehensive assessment of occupational health risks and environmental health risks through the collaborative work of its various modules. It overcomes the shortcomings of existing technologies, such as separate assessment methods and incomplete approaches, and provides enterprises in operation with a more comprehensive and accurate tool for assessing human health risks.

Claims

1. A method for calculating enterprise human health risk assessment, characterized in that, Includes the following steps: S1: Based on the occupational hazard factor detection and evaluation report, identify the areas, positions, and harmful chemical factors with occupational health risks, and clarify their acute and chronic / subchronic health risks; S2: Based on the enterprise's self-monitoring report and soil and groundwater environmental survey data, identify key monitoring units for soil and groundwater, characteristic pollutants of the enterprise, and calculate the detection concentration of each detection factor in soil and groundwater samples; S3: Compile the hazardous chemical factors with chronic / subchronic health risks in occupational health testing reports, as well as the factors detected in soil and groundwater surveys; compare the differences between hazardous chemical factors in the workplace and the factors detected in soil and groundwater, and conduct supplementary testing for the differential factors; S4: Based on the layout plan of the production enterprises, key monitoring units for soil and groundwater and areas with hazardous chemical factors in the workplace are divided, the spatial overlap between the two is determined, and they are divided into three types of areas. S5: For the three types of areas, list all possible exposure routes and include skin contact with chemicals and skin contact with groundwater in the exposure route system; S6: For areas that are key monitoring units for soil and groundwater and have workplace hazardous chemical factors, the human health risk of gaseous hazardous factors / pollutants under the inhalation route shall be recalculated using the concentration of hazardous chemical factors in the air obtained from occupational health monitoring. S7: If there are exposure routes such as skin contact with chemicals or skin contact with groundwater, quantify the exposure amount and calculate the corresponding human health risk level. S8: Based on the company's actual production situation, site conditions, and job characteristics, screen the actual exposure pathways in each area and perform risk characterization calculations; for the same chemical substance, compare its carcinogenic risk calculation results with 10 -4 Comparisons are made to determine whether the carcinogenic risk is acceptable; S9: Based on the combined results of occupational health testing and soil and groundwater surveys, analyze the overall carcinogenic risk and non-carcinogenic hazard quotient of human health under various exposure routes, identify areas with unacceptable risks and harmful factors, and propose corresponding risk management or health protection measures.

2. The enterprise human health risk assessment calculation method according to claim 1, characterized in that, The specific division of the three region types mentioned in step S4 is as follows: 1) Type 1: There are only chemical hazards in the workplace, but it does not belong to the key monitoring units for soil and groundwater; 2) The second type: It belongs to the key monitoring unit for soil and groundwater, but there are no workplace chemical hazards; 3) The third type: It belongs to the key monitoring unit for soil and groundwater and there are chemical hazards in the workplace.

3. The enterprise human health risk assessment calculation method according to claim 1, characterized in that, Step S5, based on the three region types, identifies the possible exposure pathways, specifically including: 1) The first type of possible exposure routes include: ① skin contact with chemicals; ② inhalation of harmful chemicals; 2) The second type of possible exposure routes include: ① oral ingestion of soil; ② skin contact with soil; ③ inhalation of soil particulate matter; ④ inhalation of gaseous pollutants from the top layer of soil in outdoor air; ⑤ inhalation of gaseous pollutants from the lower layer of soil in outdoor air; ⑥ inhalation of gaseous pollutants from the lower layer of soil in indoor air; ⑦ inhalation of gaseous pollutants from groundwater in outdoor air; ⑧ inhalation of gaseous pollutants from groundwater in indoor air; ⑨ drinking groundwater; ⑩ skin contact with groundwater. 3) The third type of possible exposure routes include: ① oral ingestion of soil; ② skin contact with soil; ③ skin contact with chemicals; ④ inhalation of soil particles; ⑤ inhalation of harmful chemicals; ⑥ drinking groundwater; ⑦ skin contact with groundwater.

4. The enterprise human health risk assessment calculation method according to claim 1, characterized in that, In step S6, for the third type of area, the exposure concentration of hazardous chemicals in the air obtained from occupational health testing is used to calculate the exposure concentration for employees in relevant positions, and the human health risk under the inhalation route is recalculated accordingly; the formulas for calculating the carcinogenic risk and non-carcinogenic hazard quotient are as follows: In the formula: HQ is the non-carcinogenic hazard quotient; IR is the carcinogenic risk; CA is the concentration of hazardous chemicals in the air, in μg / m³. 3 ET is the daily exposure time, h / d; EF is the daily exposure frequency, d / a; ED is the exposure duration, a; Rfc is the reference exposure concentration; AT is the average exposure time (ED × 365 d / a × 24 h / d), h; IUR is the inhalation unit risk, (μg / m³). 3 ) -1 ; t E To determine the length of service, a; t L a represents lifetime life expectancy.

5. The enterprise human health risk assessment calculation method according to claim 1, characterized in that, In step S7, the following formula is used to conduct a quantitative risk assessment of the exposure routes of skin contact with chemicals and skin contact with contaminants in groundwater: In the formula: HQ stands for non-carcinogenic hazard quotient; CR stands for carcinogenic risk; SAE stands for exposed skin surface area, in cm². 2 EF represents the exposure frequency, d / a; ED represents the exposure period, a; EV represents the frequency of skin contact events, times / day; DA represents the absorbed dose through skin contact, mg / cm³. 2 BW represents body weight, in kg; AT nc The mean time for non-carcinogenic effects is given in days (d). AT ca The mean time to carcinogenic effect, d; RfD d For skin contact reference dose, mg / (kg·d); SF d The carcinogenicity rate factor for skin contact is mg / (kg·d); in: The formula for calculating the DA of inorganic substances is as follows: The formula for calculating the DA of organic matter is as follows: K p C represents the skin permeability coefficient, in cm / h; C represents the concentration of pollutants in groundwater, or the concentration of chemicals in skin contact, in mg / L; t event τ represents the duration of each skin contact, in hours (h); FA represents the water absorption rate, dimensionless; τ event t* represents the hysteresis interval per contact, in hours (h / contact); t* represents the steady-state arrival time, in hours (h); B represents the ratio of the permeability coefficients of the stratum corneum to the active epidermis, dimensionless.

6. A corporate human health risk assessment calculation system, used to implement the method as described in claim 1, characterized in that, include: The data acquisition module is used to acquire occupational health testing data and soil and groundwater environmental survey data of the target enterprise. The area division module, connected to the data acquisition module, is used to divide the key soil and groundwater monitoring modules and the areas with workplace chemical hazards according to the enterprise layout plan, and to determine the spatial overlap between the two. An exposure pathway identification module is connected to the area division module and is used to identify possible exposure pathways in each area based on the area division results, and to include skin contact with chemicals and skin contact with groundwater in the exposure pathway system. The risk assessment module, connected to the exposure pathway identification module, is used to calculate the comprehensive carcinogenic risk and non-carcinogenic hazard quotient of human health based on the identified exposure pathways, combined with occupational health monitoring data and soil and groundwater environmental survey data, and output the risk assessment results.

7. The enterprise human health risk assessment system according to claim 1, characterized in that, The risk assessment module includes: The inhalation risk calculation subunit is used to calculate the human health risk via inhalation based on occupational health monitoring data in areas where workplace chemical hazards exist. The skin contact risk calculation subunit is used to quantify the exposure amount and calculate the corresponding human health risk level when there are exposure routes such as skin contact with chemicals or skin contact with groundwater. The comprehensive risk characterization subunit, connected to the inhalation risk calculation subunit and the skin contact risk calculation subunit, is used to integrate risks from various routes, calculate the comprehensive carcinogenic risk and non-carcinogenic hazard quotient, compare it with a preset threshold, and output the areas and harmful factors where the risk is unacceptable.

8. An electronic device comprising a memory, a processor, and a computer program stored in the memory and executable on the processor, characterized in that, When the processor executes the program, it implements the steps of the enterprise human health risk assessment calculation method as described in any one of claims 1 to 5.

9. A non-transitory computer-readable storage medium having a computer program stored thereon, characterized in that, When the computer program is executed by the processor, it implements the steps of the enterprise human health risk assessment calculation method as described in any one of claims 1 to 5.

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