A method for preparing ARA microcapsules

Abstract

This invention discloses a method for preparing ARA microcapsules, comprising the following steps: mixing 70-100 parts of galactooligosaccharides, 20-30 parts of carrageenan, 50-90 parts of maltodextrin, 150-200 parts of whey protein, and 500 parts of water to prepare an aqueous wall material solution; mixing 0.5-1 parts of vitamin C, 0.2-0.4 parts of dicalcium phosphate, and 50 parts of water to prepare an additive solution; mixing 0.35-1 parts of ARA, 0.5-1 parts of lecithin, and 4-5 parts of corn germ oil to prepare an oil phase core material solution; shearing and mixing the aqueous wall material solution, oil phase core material solution, and additive solution, and then preparing ARA microcapsules by spray drying. This invention overcomes the shortcomings of existing technologies and improves the encapsulation efficiency of ARA microcapsules.

Description

Technical Field

[0001] This invention relates to the field of microcapsule preparation technology, and in particular to a method for preparing ARA microcapsules. Background Technology

[0002] Eicosapentaenoic acid (ARA) is the most abundant and widely distributed non-toxic fatty acid in the human body. ARA plays important roles in lowering blood lipids, anti-oxidation, anti-inflammation, and promoting nervous system development. Microencapsulation is a technology that uses a wall material to encapsulate a core material, forming tiny particles, to improve the storage stability of the core material and regulate its absorption rate in the human body. Microencapsulation of ARA is a common method for preparing ARA additives in existing technologies. Summary of the Invention

[0003] The technical problem to be solved by the present invention is to provide a method for preparing ARA microcapsules, which can overcome the shortcomings of the prior art and improve the encapsulation rate of ARA microcapsules.

[0004] To solve the above-mentioned technical problems, the technical solution adopted by the present invention is as follows.

[0005] A method for preparing ARA microcapsules includes the following steps: A water-phase wall material solution is prepared by mixing 70-100 parts of galactooligosaccharides, 20-30 parts of carrageenan, 50-90 parts of maltodextrin, 150-200 parts of whey protein and 500 parts of water. Mix 0.5 to 1 part of vitamin C, 0.2 to 0.4 parts of dicalcium phosphate, and 50 parts of water to prepare an additive solution; Mix 0.35–1 part ARA, 0.5–1 part lecithin and 4–5 parts corn germ oil to prepare an oil phase core material solution; ARA microcapsules were prepared by shearing and mixing aqueous wall material solution, oil core material solution and additive solution, and then by spray drying process.

[0006] Preferably, the aqueous wall material solution consists of 78 parts of galactooligosaccharides, 25 parts of carrageenan, 880 parts of maltodextrin, 200 parts of whey protein, and 500 parts of water.

[0007] Preferably, the additive solution consists of 0.5 parts vitamin C, 0.3 parts dicalcium phosphate, and 50 parts water.

[0008] Preferably, the oil phase core solution consists of 0.5 parts of ARA, 0.5 parts of lecithin, and 5 parts of corn germ oil.

[0009] Preferably, a shear spray device is used to shear mix and spray dry the mixed solution. The shear spray device includes a tank, with an oil phase inlet pipe at the bottom and an aqueous phase inlet pipe at the top. A partition is installed in the middle of the tank, and a stirring plate is installed above and below the partition. The stirring plate is connected to a motor via a transmission rod. Several through holes are opened on the partition, and an arc-shaped baffle is fixed at the top and bottom of each through hole. The installation positions of two arc-shaped baffles on the same through hole are collinear with the center of the through hole. A metal wire mesh cover is fixed to the bottom surface of the through hole. A first liquid outlet pipe is installed above the partition, and a second liquid outlet pipe is installed below the partition. The tank is connected to the drying chamber via an atomizing pipe. The atomizing pipe includes an inner sleeve and an outer sleeve arranged concentrically. Atomizers are installed at the outlets of the inner sleeve and the outer sleeve. The first liquid outlet pipe is connected to the outer sleeve, and the second liquid outlet pipe is connected to the inner sleeve. The outlet direction of the outer sleeve is inclined towards the inner sleeve, and the angle between the outlet direction of the outer sleeve and the outlet direction of the inner sleeve is 20-40°.

[0010] Preferably, the mixing tray includes an annular frame, within which a plurality of mixing blades are uniformly fixed, and the mixing blades have slotted holes. Preferably, a peristaltic pump is installed on the first outlet pipe and the second outlet pipe respectively, and the ratio of the outlet flow rate of the first outlet pipe to the outlet flow rate of the second outlet pipe is 3:1.

[0011] The beneficial effects of adopting the above technical solution are as follows: This invention improves the encapsulation rate and reduces the oil content on the microcapsule surface by optimizing the composition of the wall material. The use of additives improves the stability of the core material. By designing a novel shear spraying device, the shear mixing effect of the mixed solution is improved, and the spraying process is also improved, further increasing the encapsulation rate of the microcapsules. Attached Figure Description

[0012] Figure 1 This is a schematic diagram of a specific embodiment of the present invention.

[0013] Figure 2 This is a structural diagram of a shear spray device according to a specific embodiment of the present invention.

[0014] Figure 3 This is a partially enlarged view of the partition in a specific embodiment of the present invention.

[0015] Figure 4 This is a partial enlarged view of the outlet of the atomizing tube in a specific embodiment of the present invention.

[0016] Figure 5 This is a partially enlarged view of the stirring plate in a specific embodiment of the present invention. Detailed Implementation

[0017] Reference Figure 1The method for preparing ARA microcapsules disclosed in this invention includes the following steps: A water-phase wall material solution was prepared by mixing 78 parts of galactooligosaccharides, 25 parts of carrageenan, 880 parts of maltodextrin, 200 parts of whey protein, and 500 parts of water.

[0018] An additive solution is prepared by mixing 0.5 parts of vitamin C, 0.3 parts of dicalcium phosphate, and 50 parts of water.

[0019] A solution of oil phase core material was prepared by mixing 0.5 parts of ARA, 0.5 parts of lecithin and 5 parts of corn germ oil.

[0020] ARA microcapsules were prepared by shearing and mixing aqueous wall material solution, oil core material solution and additive solution, and then by spray drying process.

[0021] The mixed solution is shear-mixed and spray-dried using a shear spray device. (Refer to...) Figure 2-5 The shear spraying equipment includes a tank body 1. An oil phase inlet pipe 2 is installed at the bottom of the tank body 1, and a water phase inlet pipe 3 is installed at the top of the tank body 1. A partition 4 is installed in the middle of the tank body 1. A stirring plate 5 is installed above and below the partition 4, and the stirring plate 5 is connected to a motor 7 via a transmission rod 6. Several through holes 8 are provided on the partition 4. An arc-shaped baffle 9 is fixed at the top and bottom of each through hole 8. The installation positions of two arc-shaped baffles 9 on the same through hole 8 are collinear with the center of the through hole 8. A metal wire mesh cover plate 10 is fixed to the bottom surface of the through hole 8. A first liquid outlet pipe 12 is provided above the partition 4, and a second liquid outlet pipe 13 is provided below the partition 4. The tank 1 is connected to the drying chamber 14 through an atomizing pipe. The atomizing pipe includes an inner sleeve 15 and an outer sleeve 16 arranged concentrically. Atomizers 17 are respectively provided at the outlets of the inner sleeve 15 and the outer sleeve 16. The first liquid outlet pipe 12 is connected to the outer sleeve 16, and the second liquid outlet pipe 13 is connected to the inner sleeve 15. The outlet direction of the outer sleeve 16 is inclined towards the inner sleeve 15, and the angle between the outlet direction of the outer sleeve 16 and the outlet direction of the inner sleeve 15 is 30°. The stirring plate 5 includes an annular frame 18, and a plurality of stirring blades 19 are uniformly fixed inside the annular frame 18. The stirring blades 19 have strip-shaped holes 20. Peristaltic pumps 11 are respectively installed on the first liquid outlet pipe 12 and the second liquid outlet pipe 13. The ratio of the liquid flow rate of the first liquid outlet pipe 12 to the liquid flow rate of the second liquid outlet pipe 13 is 3:1. The drying temperature in drying chamber 14 is 150℃.

[0022] The denser aqueous solution enters tank 1 from the top, while the lighter oil solution enters from the bottom. Under the stirring action of the stirring plate 19, they are mixed alternately at the baffle 4. During the rotational agitation, the solution is blocked by the arc-shaped baffle 9, forming a localized turbulent region at the through-hole location, thus achieving efficient mixing at the through-hole. Since the mixing process mainly occurs at the bottom of the through-hole, the mixing effect can be improved by adding a wire mesh cover plate 10, which continuously generates and breaks up microbubbles.

[0023] After the shearing and mixing process is completed, the mixed solution is delivered to the atomizing tube at a constant speed by the peristaltic pump 11. The atomizing tube has a two-layer design. The mixed solution delivered by the outer tube 16 has a higher content of oil phase substances, while the mixed solution delivered by the inner tube 15 has a higher content of water phase substances. This forms a cross-spraying atomized fluid at the nozzle, which allows the wall material to fully encapsulate the core material and improves the encapsulation rate.

[0024] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of the present invention as claimed. The scope of protection of this invention is defined by the appended claims and their equivalents.

Claims

1. A method for preparing ARA microcapsules, characterized in that... Includes the following steps: A water-phase wall material solution is prepared by mixing 70-100 parts of galactooligosaccharides, 20-30 parts of carrageenan, 50-90 parts of maltodextrin, 150-200 parts of whey protein and 500 parts of water. Mix 0.5 to 1 part of vitamin C, 0.2 to 0.4 parts of dicalcium phosphate, and 50 parts of water to prepare an additive solution; Mix 0.35–1 part ARA, 0.5–1 part lecithin and 4–5 parts corn germ oil to prepare an oil phase core material solution; ARA microcapsules were prepared by shearing and mixing aqueous wall material solution, oil core material solution and additive solution, and then by spray drying process.

2. The method for preparing ARA microcapsules according to claim 1, characterized in that: The aqueous wall material solution consists of 78 parts of galacto-oligosaccharides, 25 parts of carrageenan, 880 parts of maltodextrin, 200 parts of whey protein, and 500 parts of water.

3. The method for preparing ARA microcapsules according to claim 1, characterized in that: The additive solution consists of 0.5 parts vitamin C, 0.3 parts dicalcium phosphate, and 50 parts water.

4. The method for preparing ARA microcapsules according to claim 1, characterized in that: The oil phase core solution consists of 0.5 parts ARA, 0.5 parts lecithin, and 5 parts corn germ oil.

5. The method for preparing ARA microcapsules according to claim 1, characterized in that: The mixed solution is sheared and sprayed to dry using a shear spray device. The shear spray device includes a tank (1), with an oil phase inlet pipe (2) at the bottom and an aqueous phase inlet pipe (3) at the top. A partition (4) is provided in the middle of the tank (1), and a stirring plate (5) is installed above and below the partition (4). The stirring plate (5) is connected to a motor (7) via a transmission rod (6). Several through holes (8) are provided on the partition (4). An arc-shaped baffle (9) is fixed at the top and bottom of each through hole (8). The installation positions of the two arc-shaped baffles (9) on the same through hole (8) are collinear with the center of the through hole (8). The bottom surface of the through hole (8) is fixed. There is a metal wire mesh cover (10); a first liquid outlet pipe (12) is provided above the partition (4), and a second liquid outlet pipe (13) is provided below the partition (4). The tank (1) is connected to the drying chamber (14) through an atomizing pipe. The atomizing pipe includes an inner sleeve (15) and an outer sleeve (16) arranged concentrically. Atomizers (17) are provided at the outlets of the inner sleeve (15) and the outer sleeve (16). The first liquid outlet pipe (12) is connected to the outer sleeve (16), and the second liquid outlet pipe (13) is connected to the inner sleeve (15). The outlet direction of the outer sleeve (16) is inclined towards the inner sleeve (15), and the angle between the outlet direction of the outer sleeve (16) and the outlet direction of the inner sleeve (15) is 20 to 40°.

6. The method for preparing ARA microcapsules according to claim 5, characterized in that: The mixing plate (5) includes an annular frame (18), and several stirring blades (19) are uniformly fixed inside the annular frame (18). The stirring blades (19) have strip holes (20).

7. The method for preparing ARA microcapsules according to claim 6, characterized in that: A peristaltic pump (11) is installed on the first outlet pipe (12) and the second outlet pipe (13), respectively. The ratio of the outlet flow rate of the first outlet pipe (12) to the outlet flow rate of the second outlet pipe (13) is 3:1.

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