A topical antibacterial agent to prevent underarm odor

Abstract

This invention provides a topical antibacterial agent for preventing underarm odor, belonging to the field of antibacterial agent technology. The topical antibacterial agent is composed of the antibacterial drug compound sulfamethoxazole, the fast-acting bactericidal drug medical disinfectant alcohol, water, a solubilizer, and a stabilizer, and contains no antiperspirant ingredients. The compound sulfamethoxazole content is 1-100 g / L, the medical disinfectant alcohol content is 400-800 g / L, and the water content is 100-550 g / L. This antibacterial agent achieves an anti-underarm odor effect for 2-5 days through the synergistic effect of alcohol rapidly reducing the number of bacteria on the armpit surface and compound sulfamethoxazole's long-lasting inhibition of bacterial proliferation. Even after heavy sweating, reapplication is unnecessary for quick odor elimination. Simultaneously, this antibacterial agent does not block human sweat glands, does not disrupt normal perspiration function, has high safety, and has no obvious side effects. The antibacterial agent of this invention is simple to prepare, low in cost, and in spray form, making it convenient to use and combining practicality and economy.

Description

Technical Field

[0001] This invention relates to the field of antibacterial agents, and more particularly to a topical antibacterial agent for preventing underarm odor. Background Technology

[0002] Body odor, or bromhidrosis, is a common problem caused by the decomposition of secretions from the apocrine sweat glands in the armpits by microorganisms on the skin, producing unsaturated fatty acids and other substances with a distinctive odor. This problem has a certain incidence rate among the population, causing varying degrees of distress in the daily social interactions and psychological well-being of those affected.

[0003] Currently, the main approaches to improving underarm odor focus on two main directions: antiperspirant intervention and the application of single antibacterial products. Antiperspirants, represented by aluminum salts and urotropine, work by blocking sweat gland ducts to reduce sweat secretion, thereby decreasing the amount of substrate produced by bacteria. However, these products have significant drawbacks. Long-term or frequent use can easily clog the pores of the armpit skin, disrupting the body's normal sweating and heat dissipation functions, and can also cause adverse reactions such as skin redness, itching, and allergies. Furthermore, antiperspirant residue can easily stain clothing and is difficult to wash off.

[0004] Single-component antibacterial products, such as alcohol sprays and antibacterial powders, can inhibit bacterial growth on the skin to some extent, but their effects are short-lived. Alcohol sprays rely on the rapid bactericidal effect of alcohol to quickly reduce the number of bacteria in the armpits, but the antibacterial effect disappears as soon as the alcohol evaporates, and bacteria multiply rapidly. They typically only maintain an odor-free state for a few hours to a day. While compound sulfamethoxazole preparations have a slightly longer antibacterial duration than alcohol, lasting 1-2 days, they cannot quickly eliminate a large number of existing bacteria on the skin when used alone. Their initial antibacterial efficiency is low, making it difficult to meet the demand for long-lasting prevention of underarm odor.

[0005] In addition, some products targeting underarm odor have problems such as complex ingredients, high risk of side effects, high price, and cumbersome usage procedures, making it impossible to balance safety, long-lasting effect, and convenience. Therefore, there is an urgent need and application value in developing an anti-underarm odor product that can quickly kill bacteria, inhibit bacteria for a long time, does not affect the normal physiological functions of the human body, and is easy to use. Summary of the Invention

[0006] This invention provides a topical antibacterial agent to prevent underarm odor, thereby overcoming the deficiencies in the prior art.

[0007] This invention provides a topical antibacterial agent for preventing underarm odor, comprising an antibacterial drug, a rapidly killing bactericide, and a solvent. The antibacterial drug is compound sulfamethoxazole, the rapidly killing bactericide is medical disinfectant alcohol, and the solvent is water. The content of compound sulfamethoxazole in the antibacterial agent is 1-100 g / L, the content of alcohol is 400-800 g / L, the content of water is 100-550 g / L, and the volume fraction concentration of alcohol in the antibacterial agent is 45%-90%. The invention also includes a co-solvent and a stabilizer. The co-solvent is used to improve the solubility of compound sulfamethoxazole in the system, and the stabilizer is used to prevent the compound sulfamethoxazole from precipitating in the antibacterial agent.

[0008] According to the present invention, a topical antibacterial agent for preventing axillary odor is provided, wherein the compound sulfamethoxazole comprises sulfamethoxazole and the synergist trimethoprim, and the mass ratio of sulfamethoxazole to trimethoprim is 5:1.

[0009] According to the present invention, a topical antibacterial agent for preventing underarm odor is provided, wherein the cosolvent is one or a combination of two of propylene glycol and glycine.

[0010] According to the present invention, a topical antibacterial agent for preventing axillary odor is provided, wherein the stabilizer is one of a polymer stabilizer, a polyethylene glycol stabilizer, a chelating stabilizer, or a pH buffer system stabilizer, which inhibits the crystallization of compound sulfamethoxazole in liquid formulations.

[0011] According to the present invention, a topical antibacterial agent for preventing underarm odor is provided, wherein the topical antibacterial agent is a low-viscosity colorless liquid and is in the form of a spray.

[0012] According to the present invention, a topical antibacterial agent for preventing underarm odor is provided, wherein the topical antibacterial agent also includes perfume.

[0013] According to the present invention, a topical antibacterial agent for preventing underarm odor is provided, wherein the content of compound sulfamethoxazole is 2-20 g / L, the content of alcohol is 500-700 g / L, and the content of water is 200-400 g / L.

[0014] This invention provides a topical antibacterial agent for preventing underarm odor. Through the synergistic effect of medical disinfectant alcohol and compound sulfamethoxazole, it achieves an organic combination of rapid sterilization and long-lasting antibacterial effect. Medical disinfectant alcohol can quickly reduce the number of live bacteria causing underarm odor in the armpit to an extremely low level, laying the foundation for subsequent antibacterial action. In individuals with underarm odor, without medication, it takes a period of time (Tz) for noticeable underarm odor to develop due to accumulated perspiration and increasing bacterial count after bathing. If alcohol is used to sterilize the armpit after bathing, the bacterial count can be immediately reduced to a very low level. It then takes a period of time (Tx) for the bacterial count to return to the level before alcohol sterilization. Thus, the time from bacterial proliferation to causing underarm odor after alcohol sterilization is Tx + Tz. Compound sulfamethoxazole is a broad-spectrum antibacterial drug that can extend the time for bacteria to multiply from one level to another by a factor of K. When compound sulfamethoxazole is used alone in the armpit after bathing, the time for bacteria to multiply to cause underarm odor is K * Tz. When alcohol and compound sulfamethoxazole are applied to the armpits simultaneously after bathing, the time it takes for bacteria to multiply and cause body odor is K∗(T). X +T Z (), far higher than T when alcohol is used alone. X +T Z Or use alone K*T compound sulfamethoxazole Z In practical applications, using this antibacterial agent after bathing can achieve a long-lasting anti-underarm odor effect for 2-5 days. Even when excessive sweating causes some of the medication to wear off and underarm odor begins to appear, it can be reused without bathing and still quickly suppress odor production. This antibacterial agent does not contain any antiperspirant ingredients, will not block the sweat gland ducts, and does not disrupt normal sweating and heat dissipation, thus avoiding skin allergies and clogged pores caused by traditional antiperspirants. Its core ingredients, medical alcohol and compound sulfamethoxazole, are both commonly used clinical drugs with low side effects. No adverse reactions caused by this preparation have been observed after many years of use, and its long-term safety has been verified. This antibacterial agent is a low-viscosity, colorless liquid that can be prepared as a spray for easy direct application to the underarm skin. It is simple to use and the dosage is easy to control. A suitable amount of perfume can be added according to personal preference, and the perfume ingredients will not affect the antibacterial effect, balancing practicality and personalization needs. This antibacterial agent is not only effective in preventing and improving underarm odor, but can also be sprayed on the inside of shoes that are difficult to clean. By inhibiting the growth of bacteria on the feet, it effectively improves foot odor problems, covering two common areas of body odor. The core ingredients of this antibacterial agent are all commercially available, conventional raw materials, requiring no complex preparation processes or special production equipment, making it easy to mass-produce industrially. The low cost of the raw materials gives it a significant price advantage compared to some high-end underarm odor care products on the market, meeting the needs of different consumer groups. Detailed Implementation

[0015] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the implementation of the present invention. Obviously, the described embodiments are some embodiments of the present invention, but not all embodiments.

[0016] Based on the embodiments of this invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this invention.

[0019] This application provides a topical antibacterial agent for preventing underarm odor, comprising an antibacterial drug, a rapidly killing drug, and a solvent. The antibacterial drug is compound sulfamethoxazole, the rapidly killing drug is medical disinfectant alcohol, and the solvent is water. The content of compound sulfamethoxazole in the antibacterial agent is 1-100 g / L, the content of alcohol is 400-800 g / L, the content of water is 100-550 g / L, and the volume fraction concentration of alcohol in the antibacterial agent is 45%-90%. It also includes a co-solvent and a stabilizer. The co-solvent is used to improve the solubility of compound sulfamethoxazole in the system, and the stabilizer is used to prevent the compound sulfamethoxazole from precipitating in the antibacterial agent.

[0020] To further optimize the above technical solution, the compound sulfamethoxazole includes sulfamethoxazole and the synergist trimethoprim, and the mass ratio of sulfamethoxazole to trimethoprim is 5:1.

[0021] To further optimize the above technical solution, the co-solvent is one or a combination of two of propylene glycol and glycine.

[0022] To further optimize the above technical solution, the stabilizer is one of the following: polymer stabilizer, polyethylene glycol stabilizer, chelating stabilizer, or pH buffer system stabilizer, to inhibit the crystallization of compound sulfamethoxazole in liquid formulation.

[0023] To further optimize the above technical solution, the external antibacterial agent is a low-viscosity colorless liquid, and the dosage form is a spray.

[0024] To further optimize the above technical solutions, topical antibacterial agents also include perfumes.

[0025] To further optimize the above technical solution, the content of compound sulfamethoxazole is 2-20 g / L, the content of alcohol is 500-700 g / L, and the content of water is 200-400 g / L.

[0026] To provide a clearer and more detailed description of the topical antibacterial agent for preventing underarm odor provided in the embodiments of the present invention, the following description will be based on specific embodiments.

[0027] Example 1

[0028] In this embodiment, the antibacterial agent is prepared in 1L. The formulation consists of 20g of compound sulfamethoxazole, 700g of medical disinfectant alcohol, 280g of purified water, 5g of propylene glycol as a solubilizer, and 0.5g of sodium carboxymethyl cellulose as a stabilizer. During preparation, propylene glycol and sodium carboxymethyl cellulose are first added to purified water and stirred until completely dissolved. Then, compound sulfamethoxazole is added and stirred continuously until evenly dispersed. Next, medical disinfectant alcohol is slowly added and thoroughly mixed to obtain a clear, transparent, colorless liquid. The liquid is then filled into a spray bottle to obtain the finished external antibacterial agent.

[0029] Twenty subjects with bromhidrosis were selected to use this preparation. After bathing, the preparation was evenly sprayed onto the skin surface of the armpits. The results showed that the average time from bacterial proliferation in the armpits to the onset of bromhidrosis was up to 5 days. During this period, the subjects could reapply the preparation after sweating heavily without bathing, and the odor could be quickly eliminated. Moreover, none of the subjects experienced any discomfort such as skin redness, itching, or stinging. The preparation showed excellent safety and effectiveness. Example 2

[0030] In this embodiment, 1L of the topical antibacterial agent was prepared. The formulation consisted of 50g of compound sulfamethoxazole, 500g of medical disinfectant alcohol, 450g of purified water, 8g of glycine as a solubilizer, and 10g of polyethylene glycol 400 as a stabilizer. During preparation, glycine and polyethylene glycol 400 were first added to purified water and stirred to dissolve. Then, compound sulfamethoxazole was added and stirred until completely dispersed. Next, medical disinfectant alcohol was added and mixed thoroughly. After filtration, the mixture was filled into a spray bottle to obtain a topical antibacterial spray that met the requirements.

[0031] Twenty subjects with bromhidrosis were selected to use this preparation. After showering, the preparation was sprayed into the armpits. The subjects' armpits remained odor-free for an average of 3 days. At the same time, the preparation was sprayed into the inside of shoes that are difficult to clean. It can effectively inhibit the growth of bacteria on the skin surface of the feet, thereby significantly improving the problem of foot odor. The effect can last until the next shoe wash, which fully demonstrates the dual role of this preparation in the prevention and treatment of bromhidrosis and foot odor. Example 3

[0032] This embodiment prepares 1L of the topical antibacterial agent, which consists of 2g of compound sulfamethoxazole, 400g of medical disinfectant alcohol, 598g of purified water, 3g each of propylene glycol and glycine as cosolvents, 0.3g of disodium EDTA as stabilizer, and an appropriate amount of phosphate buffer. During preparation, propylene glycol, glycine, disodium EDTA, and phosphate buffer are first added to purified water and stirred to dissolve. Simultaneously, the pH of the system is adjusted to 6.5. Then, compound sulfamethoxazole is added and stirred until evenly dispersed. Next, medical disinfectant alcohol is slowly added and thoroughly mixed to obtain a clear and transparent topical antibacterial spray.

[0033] Twenty subjects with bromhidrosis were selected, including five subjects with sensitive skin. The preparation was sprayed on the armpits after bathing. The results showed that the odor-free state of the armpits of all subjects could be maintained for an average of 2 days, and the subjects with sensitive skin did not experience any skin discomfort after use, which fully demonstrates that the low-concentration formula is both mild and effective.

[0034] Comparative Example 1 This comparative example is an antibacterial spray using medical disinfectant alcohol alone. 1L of this spray was prepared, with a formula consisting of 700g of medical disinfectant alcohol and 300g of purified water. During preparation, the medical disinfectant alcohol and purified water were thoroughly mixed and then filled into a spray bottle.

[0035] Twenty subjects with axillary odor, similar to those in the previous example, were selected to use the spray. After showering, the spray was applied to the armpits. The results showed that the spray could quickly reduce the number of bacteria in the armpits. However, after the alcohol evaporated, the bacteria multiplied rapidly. The subjects' armpits were odor-free for only 8 to 12 hours, with an average duration of less than one day. Some subjects also reported that their armpit skin became slightly dry after use. They had to reapply the spray after sweating. The odor-suppressing effect was short-lived and could not meet the need for long-lasting odor prevention.

[0036] Comparative Example 2 This comparative example is an antibacterial spray using compound sulfamethoxazole alone. 1L of this spray was prepared, with the following composition: 20g compound sulfamethoxazole, 980g purified water, 5g propylene glycol as a solubilizer, and 0.5g sodium carboxymethyl cellulose as a stabilizer. The preparation method was the same as in Example 1, except that medical disinfectant alcohol was not added.

[0037] Twenty subjects with the same armpit odor were selected to use the spray. After showering, the spray was applied to the armpits. The results showed that the initial antibacterial efficiency of the spray was low because it could not quickly remove the large number of bacteria already present on the surface of the armpit skin. The armpit odor appeared in the subjects within 1 to 2 days after showering, and the average duration of the odor-free state was only 1.5 days. Moreover, the odor was slow to take effect when the spray was applied again after sweating. The overall effect was far inferior to the antibacterial spray with the synergistic effect of alcohol and compound sulfamethoxazole in Example 1.

[0038] Table 1. Antibacterial effects of Examples 1-3 and Comparative Examples 1-2

[0039] From the comparative experimental results of Examples 1-3 and Comparative Examples 1-2, the following core conclusions can be drawn: the combination of medical disinfectant alcohol and compound sulfamethoxazole has a significant synergistic antibacterial effect. The inhibitory effect of the two on bromhidrosis-causing bacteria in the armpit is far superior to the use of either ingredient alone. Furthermore, the formulation concentration specified in the examples directly affects the efficacy of the preparation. With the preferred formulation of 20g / L compound sulfamethoxazole and 700g / L alcohol, the anti-bromhidrosis effect of the preparation is optimal, with an odor-free duration of up to 5 days. This concentration also balances antibacterial effect and formulation stability. The topical antibacterial agent of this invention has high safety and no physiological side effects. This preparation does not contain any antiperspirant ingredients, will not block sweat gland ducts, and will not disrupt the body's normal sweating function. In the experiments, none of the subjects experienced skin redness, itching, stinging, or other discomfort after use. Sensitive skin subjects also did not experience adverse reactions when using the low-concentration formulation, ensuring long-term safety.

[0040] Therefore, this invention provides a topical antibacterial agent for preventing underarm odor. Through the synergistic effect of medical disinfectant alcohol and compound sulfamethoxazole, it achieves an organic combination of rapid sterilization and long-lasting antibacterial effect. Medical disinfectant alcohol can quickly reduce the number of live bacteria causing underarm odor in the armpit to an extremely low level, laying the foundation for subsequent antibacterial action. In individuals with underarm odor, without medication, it takes a period of time (Tz) for noticeable underarm odor to develop due to the accumulation of sweat and the continuous increase in the number of bacteria in the armpit after bathing. If alcohol is used to sterilize the armpit after bathing, the number of bacteria in the armpit can be immediately reduced to a very low level. It then takes a period of time (Tx) for the number of bacteria to return to the level before alcohol sterilization. Thus, the time from bacterial proliferation to causing underarm odor after alcohol sterilization is Tx + Tz. Compound sulfamethoxazole is a broad-spectrum antibacterial drug that can extend the time for bacteria to proliferate from one quantity level to another by a factor of K. When compound sulfamethoxazole is used alone in the armpit after bathing, the time for bacteria to proliferate to causing underarm odor is K * Tz. When alcohol and compound sulfamethoxazole are applied to the armpits simultaneously after bathing, the time it takes for bacteria to multiply and cause body odor is K∗(T). X +T Z (), far higher than T when alcohol is used alone. X +T Z Or use alone K*T compound sulfamethoxazole ZIn practical applications, using this antibacterial agent after bathing can achieve a long-lasting anti-underarm odor effect for 2-5 days. Even when excessive sweating causes some of the medication to wear off and underarm odor begins to appear, it can be reused without bathing and still quickly suppress odor production. This antibacterial agent does not contain any antiperspirant ingredients, will not block the sweat gland ducts, and does not disrupt normal sweating and heat dissipation, thus avoiding skin allergies and clogged pores caused by traditional antiperspirants. Its core ingredients, medical alcohol and compound sulfamethoxazole, are both commonly used clinical drugs with low side effects. No adverse reactions caused by this preparation have been observed after many years of use, and its long-term safety has been verified. This antibacterial agent is a low-viscosity, colorless liquid that can be prepared as a spray for easy direct application to the underarm skin. It is simple to use and the dosage is easy to control. A suitable amount of perfume can be added according to personal preference, and the perfume ingredients will not affect the antibacterial effect, balancing practicality and personalization needs. This antibacterial agent is not only effective in preventing and improving underarm odor, but can also be sprayed on the inside of shoes that are difficult to clean. By inhibiting the growth of bacteria on the feet, it effectively improves foot odor problems, covering two common areas of body odor. The core ingredients of this antibacterial agent are all commercially available, conventional raw materials, requiring no complex preparation processes or special production equipment, making it easy to mass-produce industrially. The low cost of the raw materials gives it a significant price advantage compared to some high-end underarm odor care products on the market, meeting the needs of different consumer groups.

[0041] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A topical antibacterial agent for preventing underarm odor, characterized in that, The mixture includes an antibacterial agent, a rapid bactericidal agent, and a solvent. The antibacterial agent is compound sulfamethoxazole, the rapid bactericidal agent is medical disinfectant alcohol, and the solvent is water. The content of compound sulfamethoxazole in the antibacterial agent is 1-100 g / L, the content of alcohol is 400-800 g / L, the content of water is 100-550 g / L, and the volume fraction concentration of alcohol in the antibacterial agent is 45%-90%.

2. The topical antibacterial agent for preventing underarm odor according to claim 1, characterized in that, The compound sulfamethoxazole includes sulfamethoxazole and the synergist trimethoprim, and the mass ratio of sulfamethoxazole to trimethoprim is 5:

1.

3. The topical antibacterial agent for preventing underarm odor according to claim 1, characterized in that, It also includes a cosolvent, which is one or a combination of two of propylene glycol and glycine.

4. The topical antibacterial agent for preventing underarm odor according to claim 1, characterized in that, It also includes a stabilizer, which is one of the following: a polymer stabilizer, a polyethylene glycol stabilizer, a chelating stabilizer, or a pH buffer system stabilizer, to inhibit the crystallization of compound sulfamethoxazole in liquid formulations.

5. The topical antibacterial agent for preventing underarm odor according to claim 1, characterized in that, The topical antibacterial agent is a low-viscosity, colorless liquid, and is in the form of a spray.

6. The topical antibacterial agent for preventing underarm odor according to claim 1, characterized in that, The topical antibacterial agents also include perfumes.

7. The topical antibacterial agent for preventing underarm odor according to claim 1, characterized in that, The content of the compound sulfamethoxazole is 2-20 g / L, the content of the alcohol is 500-700 g / L, and the content of the water is 200-400 g / L.

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